A defective viral genome strategy elicits broad protective immunity against respiratory viruses
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DOI: 10.1016/j.cell.2021.11.023
Abstract: RNA viruses generate defective viral genomes (DVG) that can interfere with replication of the parental wild-type virus. To examine their therapeutic potential, we created a DVG by deleting the capsid-coding region of poliovirus. Strikingly, intraperitoneal… read more here.
Keywords: genome strategy; defective viral; strategy elicits; sars cov ... See more keywords