Enhancer accessibility and CTCF occupancy underlie asymmetric TAD architecture and cell type specific genome topology
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-10725-9
Abstract: Cohesin and CTCF are master regulators of genome topology. How these ubiquitous proteins contribute to cell-type specific genome structure is poorly understood. Here, we explore quantitative aspects of topologically associated domains (TAD) between pluripotent embryonic… read more here.
Keywords: tad; genome topology; topology; ctcf ... See more keywords
Integration of 3D genome topology and local chromatin features uncovers enhancers underlying craniofacial-specific cartilage defects
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abo3648
Abstract: Aberrations in tissue-specific enhancers underlie many developmental defects. Disrupting a noncoding region distal from the human SOX9 gene causes the Pierre Robin sequence (PRS) characterized by the undersized lower jaw. Such a craniofacial-specific defect has… read more here.
Keywords: topology; cartilage; craniofacial specific; genome topology ... See more keywords
The Clock Takes Shape—24 h Dynamics in Genome Topology
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.799971
Abstract: Circadian rhythms orchestrate organismal physiology and behavior in order to anticipate daily changes in the environment. Virtually all cells have an internal rhythm that is synchronized every day by Zeitgebers (environmental cues). The synchrony between… read more here.
Keywords: genome topology; topology; clock takes; circadian rhythms ... See more keywords