Pan-cancer genome and transcriptome analyses of 1,699 pediatric leukemias and solid tumors
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/nature25795
Abstract: Analysis of molecular aberrations across multiple cancer types, known as pan-cancer analysis, identifies commonalities and differences in key biological processes that are dysregulated in cancer cells from diverse lineages. Pan-cancer analyses have been performed for… read more here.
Keywords: pan cancer; cancer genome; transcriptome analyses; genome transcriptome ... See more keywords
Whole genome and transcriptome integrated analyses guide clinical care of pediatric poor prognosis cancers
Sign Up to like & getrecommendations! Published in 2024 at "Nature Communications"
DOI: 10.1038/s41467-024-48363-5
Abstract: The role for routine whole genome and transcriptome analysis (WGTA) for poor prognosis pediatric cancers remains undetermined. Here, we characterize somatic mutations, structural rearrangements, copy number variants, gene expression, immuno-profiles and germline cancer predisposition variants… read more here.
Keywords: poor prognosis; clinical care; genome transcriptome; whole genome ... See more keywords
Whole genome and transcriptome profiling in advanced pancreatic cancer patients on the COMPASS trial
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-60808-z
Abstract: Integrated whole genome and transcriptome sequencing can unveil distinct molecular subgroups in pancreatic cancer (PDAC). The COMPASS trial (NCT02750657) enrolled 268 patients with advanced PDAC; patients were given either modified (m) FOLFIRINOX or Gemcitabine-nab-paclitaxel (GnP)… read more here.
Keywords: trial; genome transcriptome; whole genome; pancreatic cancer ... See more keywords
Prognostic genome and transcriptome signatures in colorectal cancers
Sign Up to like & getrecommendations! Published in 2024 at "Nature"
DOI: 10.1038/s41586-024-07769-3
Abstract: Colorectal cancer is caused by a sequence of somatic genomic alterations affecting driver genes in core cancer pathways1. Here, to understand the functional and prognostic impact of cancer-causing somatic mutations, we analysed the whole genomes… read more here.
Keywords: colorectal cancer; colorectal cancers; cancer; genome transcriptome ... See more keywords
The Indian cobra reference genome and transcriptome enables comprehensive identification of venom toxins
Sign Up to like & getrecommendations! Published in 2020 at "Nature Genetics"
DOI: 10.1038/s41588-019-0559-8
Abstract: Snakebite envenoming is a serious and neglected tropical disease that kills ~100,000 people annually. High-quality, genome-enabled comprehensive characterization of toxin genes will facilitate development of effective humanized recombinant antivenom. We report a de novo near-chromosomal genome… read more here.
Keywords: cobra; reference genome; venom; genome transcriptome ... See more keywords
Genome and transcriptome analysis of surfactin biosynthesis in Bacillus amyloliquefaciens MT45
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep40976
Abstract: Natural Bacillus isolates generate limited amounts of surfactin ( read more here.
Keywords: transcriptome analysis; surfactin; genome transcriptome; amyloliquefaciens mt45 ... See more keywords
Genome, transcriptome and proteome: the rise of omics data and their integration in biomedical sciences
Sign Up to like & getrecommendations! Published in 2018 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbw114
Abstract: Abstract Advances in the technologies and informatics used to generate and process large biological data sets (omics data) are promoting a critical shift in the study of biomedical sciences. While genomics, transcriptomics and proteinomics, coupled… read more here.
Keywords: rise; genome transcriptome; omics data; data integration ... See more keywords
Global quantification exposes abundant low-level off-target activity by base editors.
Sign Up to like & getrecommendations! Published in 2021 at "Genome research"
DOI: 10.1101/gr.275770.121
Abstract: Base editors are dedicated engineered deaminases that enable directed conversion of specific bases in the genome or transcriptome in a precise and efficient manner, and hold promise for correcting pathogenic mutations. A major concern limiting… read more here.
Keywords: base editors; genome transcriptome; target; base ... See more keywords
Whole-genome and transcriptome analysis of advanced adrenocortical cancer highlights multiple alterations affecting epigenome and DNA repair pathways
Sign Up to like & getrecommendations! Published in 2022 at "Cold Spring Harbor Molecular Case Studies"
DOI: 10.1101/mcs.a006148
Abstract: Adrenocortical cancer (ACC) is a rare cancer of the adrenal gland. Several driver mutations have been identified in both primary and metastatic ACCs, but the therapeutic options are still limited. We performed whole-genome and transcriptome… read more here.
Keywords: whole genome; alterations affecting; genome transcriptome; analysis ... See more keywords
Simultaneous Single-Cell Genome and Transcriptome Sequencing of Termite Hindgut Protists Reveals Metabolic and Evolutionary Traits of Their Endosymbionts
Sign Up to like & getrecommendations! Published in 2022 at "mSphere"
DOI: 10.1128/msphere.00021-22
Abstract: The composition and structure of wood, which contains cellulose, hemicellulose, and lignin, prevent most organisms from using this common food source. Termites are a rare exception among animals, and they rely on a complex microbiota… read more here.
Keywords: wood; food; genome transcriptome; source ... See more keywords
Pathologist-initiated whole genome and transcriptome sequencing demonstrates diagnostic utility in resolving difficult-to-diagnose tumors
Sign Up to like & getrecommendations! Published in 2025 at "Genome Medicine"
DOI: 10.1186/s13073-025-01534-5
Abstract: Despite significant advances in diagnostic cancer histopathology, a subset of tumors are unable to be classified using WHO criteria. The resulting diagnostic uncertainty can result in inappropriate clinical management and negative patient outcomes. We investigated… read more here.
Keywords: genome transcriptome; whole genome; difficult diagnose; diagnose tumors ... See more keywords