Pan-cancer genome and transcriptome analyses of 1,699 pediatric leukemias and solid tumors
Sign Up to like & getrecommendations! Published in 2018 at "Nature"
DOI: 10.1038/nature25795
Abstract: Analysis of molecular aberrations across multiple cancer types, known as pan-cancer analysis, identifies commonalities and differences in key biological processes that are dysregulated in cancer cells from diverse lineages. Pan-cancer analyses have been performed for… read more here.
Keywords: pan cancer; cancer genome; transcriptome analyses; genome transcriptome ... See more keywords
The Indian cobra reference genome and transcriptome enables comprehensive identification of venom toxins
Sign Up to like & getrecommendations! Published in 2020 at "Nature Genetics"
DOI: 10.1038/s41588-019-0559-8
Abstract: Snakebite envenoming is a serious and neglected tropical disease that kills ~100,000 people annually. High-quality, genome-enabled comprehensive characterization of toxin genes will facilitate development of effective humanized recombinant antivenom. We report a de novo near-chromosomal genome… read more here.
Keywords: cobra; reference genome; venom; genome transcriptome ... See more keywords
Genome and transcriptome analysis of surfactin biosynthesis in Bacillus amyloliquefaciens MT45
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep40976
Abstract: Natural Bacillus isolates generate limited amounts of surfactin ( read more here.
Keywords: transcriptome analysis; surfactin; genome transcriptome; amyloliquefaciens mt45 ... See more keywords
Genome, transcriptome and proteome: the rise of omics data and their integration in biomedical sciences
Sign Up to like & getrecommendations! Published in 2018 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbw114
Abstract: Abstract Advances in the technologies and informatics used to generate and process large biological data sets (omics data) are promoting a critical shift in the study of biomedical sciences. While genomics, transcriptomics and proteinomics, coupled… read more here.
Keywords: rise; genome transcriptome; omics data; data integration ... See more keywords
Global quantification exposes abundant low-level off-target activity by base editors.
Sign Up to like & getrecommendations! Published in 2021 at "Genome research"
DOI: 10.1101/gr.275770.121
Abstract: Base editors are dedicated engineered deaminases that enable directed conversion of specific bases in the genome or transcriptome in a precise and efficient manner, and hold promise for correcting pathogenic mutations. A major concern limiting… read more here.
Keywords: base editors; genome transcriptome; target; base ... See more keywords
Whole-genome and transcriptome analysis of advanced adrenocortical cancer highlights multiple alterations affecting epigenome and DNA repair pathways
Sign Up to like & getrecommendations! Published in 2022 at "Cold Spring Harbor Molecular Case Studies"
DOI: 10.1101/mcs.a006148
Abstract: Adrenocortical cancer (ACC) is a rare cancer of the adrenal gland. Several driver mutations have been identified in both primary and metastatic ACCs, but the therapeutic options are still limited. We performed whole-genome and transcriptome… read more here.
Keywords: whole genome; alterations affecting; genome transcriptome; analysis ... See more keywords
Simultaneous Single-Cell Genome and Transcriptome Sequencing of Termite Hindgut Protists Reveals Metabolic and Evolutionary Traits of Their Endosymbionts
Sign Up to like & getrecommendations! Published in 2022 at "mSphere"
DOI: 10.1128/msphere.00021-22
Abstract: The composition and structure of wood, which contains cellulose, hemicellulose, and lignin, prevent most organisms from using this common food source. Termites are a rare exception among animals, and they rely on a complex microbiota… read more here.
Keywords: wood; food; genome transcriptome; source ... See more keywords
Whole genome and transcriptome analysis (WGTA) of metastatic adrenocortical carcinoma (mACC).
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2019.37.15_suppl.e16123
Abstract: e16123 Background: mACC is a rare disease, and no standard treatments exist beyond cytotoxic chemotherapy and mitotane. Recurrent molecular changes have been described, but their clinical significance is still poorly understood, and whether they can… read more here.
Keywords: transcriptome analysis; whole genome; genome transcriptome; copy ... See more keywords
Whole-Genome and Transcriptome Sequencing-Based Characterization of Bacillus Cereus NR1 From Subtropical Marine Mangrove and Its Potential Role in Sulfur Metabolism
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.856092
Abstract: Sulfur, organosulfur compounds, and sulfides are essential parts of life. Microbial sulfate assimilation is among the most active and ancient metabolic activities in the sulfur cycle that operates in various ecosystems. We analyzed the molecular… read more here.
Keywords: sulfur metabolism; bacillus cereus; sulfur; genome transcriptome ... See more keywords
Genome, transcriptome, and metabolome analyses provide new insights into the resource development in an edible fungus Dictyophora indusiata
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2023.1137159
Abstract: Dictyophora indusiata (Vent. Ex Pers.) Fisch. (DI) is an edible and medicinal fungus widely used in East Asian countries. However, during DI cultivation, the formation of fruiting bodies cannot be regulated, which leads to yield… read more here.
Keywords: development; resource development; genome transcriptome; fungus ... See more keywords
Integrated analysis of whole genome and transcriptome sequencing in a young patient with gastric cancer provides insights for precision therapy
Sign Up to like & getrecommendations! Published in 2020 at "Oncology Letters"
DOI: 10.3892/ol.2020.11976
Abstract: Gastric cancer is a leading cause of cancer-associated deaths worldwide and is considered to be an age-related disease. In younger patients, gastric cancer is biologically more aggressive, and prognosis is worse compared with that in… read more here.
Keywords: whole genome; gastric cancer; genome transcriptome; patient gastric ... See more keywords