Association of Genome-Wide Polygenic Scores for Multiple Psychiatric and Common Traits in Preadolescent Youths at Risk of Suicide
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2021.48585
Abstract: Key Points Question Are genome-wide polygenic scores for specific psychiatric and common traits associated with high risk of suicide among preadolescent youths? Findings In this cohort study of 11 869 preadolescent youths in the US, multiple… read more here.
Keywords: preadolescent youths; wide polygenic; risk suicide; polygenic scores ... See more keywords
Role of the Complement System in Chronic Central Serous Chorioretinopathy: A Genome-Wide Association Study
Sign Up to like & getrecommendations! Published in 2018 at "JAMA Ophthalmology"
DOI: 10.1001/jamaophthalmol.2018.3190
Abstract: Importance To date, several targeted genetic studies on chronic central serous chorioretinopathy (cCSC) have been performed; however, unbiased genome-wide studies into the genetics of cCSC have not been reported. To discover new genetic loci associated… read more here.
Keywords: genome wide; chronic central; association; complement ... See more keywords
Genome-wide Association of Endophenotypes for Schizophrenia From the Consortium on the Genetics of Schizophrenia (COGS) Study.
Sign Up to like & getrecommendations! Published in 2019 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2019.2850
Abstract: Importance The Consortium on the Genetics of Schizophrenia (COGS) uses quantitative neurophysiological and neurocognitive endophenotypes with demonstrated deficits in schizophrenia as a platform from which to explore the underlying neural circuitry and genetic architecture. Many… read more here.
Keywords: genome wide; genetics schizophrenia; genetics; association ... See more keywords
Association of OPRM1 Functional Coding Variant With Opioid Use Disorder: A Genome-Wide Association Study.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA psychiatry"
DOI: 10.1001/jamapsychiatry.2020.1206
Abstract: Importance With the current opioid crisis, it is important to improve understanding of the biological mechanisms of opioid use disorder (OUD). Objectives To detect genetic risk variants for OUD and determine genetic correlations and causal… read more here.
Keywords: genome wide; association; association study; american individuals ... See more keywords
Genome‐wide analysis of the mouse LIM gene family reveals its roles in regulating pathological cardiac hypertrophy
Sign Up to like & getrecommendations! Published in 2021 at "FEBS Letters"
DOI: 10.1002/1873-3468.14168
Abstract: LIM‐domain proteins have been shown to be associated with heart development and diseases. Systematic studies of LIM family members at the genome‐wide level, which are crucial to further understand their functions in cardiac hypertrophy, are… read more here.
Keywords: genome wide; cardiac hypertrophy; analysis mouse; family ... See more keywords
Genome‐Wide 3′‐UTR Single Nucleotide Polymorphism Association Study Identifies Significant Prostate Cancer Risk‐Associated Functional Loci at 8p21.2 in Chinese Population
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202201420
Abstract: MicroRNAs (miRNAs) are involved in the regulation of gene expression via incomplete base pairing to sequence motifs at the three prime untranslated regions (3′‐UTRs) of mRNAs and play critical roles in the etiology of cancers.… read more here.
Keywords: prostate cancer; genome wide; association study; single nucleotide ... See more keywords
Metabolome-Based Genome-Wide Association Study of Duck Meat Leads to Novel Genetic and Biochemical Insights.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202300148
Abstract: Meat is among the most consumed foods worldwide and has a unique flavor and high nutrient density in the human diet. However, the genetic and biochemical bases of meat nutrition and flavor are poorly understood.… read more here.
Keywords: metabolome based; based genome; genome wide; wide association ... See more keywords
First genome-wide analysis of the endangered, endemic lichen Cetradonia linearis reveals isolation by distance and strong population structure.
Sign Up to like & getrecommendations! Published in 2018 at "American journal of botany"
DOI: 10.1002/ajb2.1150
Abstract: PREMISE OF THE STUDY Lichenized fungi are evolutionarily diverse and ecologically important, but little is known about the processes that drive their diversification and genetic differentiation. Distributions are often assumed to be wholly shaped by… read more here.
Keywords: genome wide; distance; cetradonia linearis; isolation ... See more keywords
Genome-wide and expression-profiling analyses of the cytochrome P450 genes in Tenebrionidea.
Sign Up to like & getrecommendations! Published in 2022 at "Archives of insect biochemistry and physiology"
DOI: 10.1002/arch.21954
Abstract: Cytochrome P450 monooxygenases (CYPs) are present in almost all areas of the tree of life. As one of the largest and most diverse superfamilies of multifunctional enzymes, they play important roles in the metabolism of… read more here.
Keywords: cyp genes; genome wide; expression; cytochrome p450 ... See more keywords
Genome‐wide CRISPR‐Cas9 screen reveals a persistent null‐hyphal phenotype that maintains high carotenoid production in Yarrowia lipolytica
Sign Up to like & getrecommendations! Published in 2022 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.28219
Abstract: Yarrowia lipolytica is a metabolic engineering host of growing industrial interest due to its ability to metabolize hydrocarbons, fatty acids, glycerol, and other renewable carbon sources. This dimorphic yeast undergoes a stress‐induced transition to a… read more here.
Keywords: screen; genome wide; yarrowia lipolytica; production ... See more keywords
Genome‐wide association studies reveal shared genetic haplotypes of autoimmune rheumatic and endocrine diseases with psychiatric disorders
Sign Up to like & getrecommendations! Published in 2023 at "Brain and Behavior"
DOI: 10.1002/brb3.2955
Abstract: Several studies have shown that autoimmune diseases are associated with psychiatric diseases like depression and psychosis. Genetic evidence supports this association. The aim of this study was to investigate if genetic variants predisposing to autoimmune… read more here.
Keywords: psychiatric disorders; genome wide; wide association; diseases psychiatric ... See more keywords