Positive Caricature Transcriptomic Effects Associated with Broad Genomic Aberrations in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-32884-3
Abstract: We re-examined the correlation between Broad Genomic Aberrations (BGAs) and transcriptomic profiles in Colorectal Cancer (CRC). Two types of BGAs have been examined: Broad Copy-Number Abnormal regions (BCNAs), distinguished in gain- and loss-type, and Copy-Neutral… read more here.
Keywords: positive caricature; caricature transcriptomic; genomic aberrations; cancer ... See more keywords
Spitz melanocytic tumours – a review
Sign Up to like & getrecommendations! Published in 2022 at "Histopathology"
DOI: 10.1111/his.14583
Abstract: Spitz tumours comprise a spectrum of melanocytic proliferations that share a set of distinct cytological features and molecular pathways. They include benign naevi, intermediate or indeterminate tumours and rare melanomas. Spitz tumours are notorious for… read more here.
Keywords: genomic aberrations; tumours review; melanocytic tumours; spitz ... See more keywords
Abstract PS2-26: Evaluating the pathogenicity of emerging genomic aberrations detected by circulating tumor DNA over the course of metastatic breast cancer
Sign Up to like & getrecommendations! Published in 2021 at "Cancer Research"
DOI: 10.1158/1538-7445.sabcs20-ps2-26
Abstract: Introduction: Previously reported data from our group and others have demonstrated an increase in genomic complexity and number of alterations over the course of treatment in MBC. Our study aims to categorize the pathogenicity of… read more here.
Keywords: course; progression; cancer; breast cancer ... See more keywords
Coexisting genomic aberrations associated with lymph node metastasis in breast cancer
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Investigation"
DOI: 10.1172/jci97449
Abstract: Single cancer cell–sequencing studies currently use randomly selected cells, limiting correlations among genomic aberrations, morphology, and spatial localization. We laser-captured microdissected single cells from morphologically distinct areas of primary breast cancer and corresponding lymph node… read more here.
Keywords: node metastasis; breast; genomic aberrations; metastasis ... See more keywords
Targeted Therapy for Advanced or Metastatic Cholangiocarcinoma: Focus on the Clinical Potential of Infigratinib
Sign Up to like & getrecommendations! Published in 2021 at "OncoTargets and therapy"
DOI: 10.2147/ott.s272208
Abstract: Abstract Cholangiocarcinoma is one of the most aggressive cancers, with a 5-year survival rate of 11–44% after surgical resection. However, there is no established systemic therapy after failure of the gemcitabine plus cisplatin first-line therapy… read more here.
Keywords: cholangiocarcinoma; therapy advanced; genomic aberrations; advanced cholangiocarcinoma ... See more keywords
T cell receptor gene repertoire profiles in subgroups of patients with chronic lymphocytic leukemia bearing distinct genomic aberrations
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1097942
Abstract: Background Microenvironmental interactions of the malignant clone with T cells are critical throughout the natural history of chronic lymphocytic leukemia (CLL). Indeed, clonal expansions of T cells and shared clonotypes exist between different CLL patients,… read more here.
Keywords: cell receptor; gene repertoire; gene; genomic aberrations ... See more keywords
Genomic aberrations in non- small cell lung cancer and their impact on treatment outcome
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Cancer Research and Therapeutics"
DOI: 10.4103/0973-1482.180605
Abstract: The therapeutic options of nonsmall cell lung cancer (NSCLC) therapy has been changed since the first discovery of activating epidermal growth factor receptor (EGFR) mutations and the development of specific EGFR tyrosine kinase inhibitors, which… read more here.
Keywords: cancer; genomic aberrations; lung cancer; cell lung ... See more keywords