Characteristics of genomic alterations of lung adenocarcinoma in young never‐smokers
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DOI: 10.1002/ijc.31542
Abstract: Non‐small‐cell lung cancer (NSCLC) has been recognized as a highly heterogeneous disease with phenotypic and genotypic diversity in each subgroup. While never‐smoker patients with NSCLC have been well studied through next generation sequencing, we have… read more here.
Keywords: lung adenocarcinoma; genomic alterations; never smoker; lung cancer ... See more keywords
The genomic alterations of lung adenocarcinoma and lung squamous cell carcinoma can explain the differences of their overall survival rates
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DOI: 10.1002/jcp.27917
Abstract: In the US, lung carcinoma accounted for over 150,000 deaths in 2018 and the advances in increasing survival rates are still limited. In this study, we investigated the cohorts with lung adenocarcinoma (LUAD) or lung… read more here.
Keywords: lung adenocarcinoma; genomic alterations; carcinoma; survival rates ... See more keywords
Correlation between dynamic susceptibility contrast perfusion MRI and genomic alterations in glioblastoma
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DOI: 10.1007/s00234-021-02674-2
Abstract: To determine if dynamic susceptibility contrast perfusion MR imaging (DSC-pMRI) can predict significant genomic alterations in glioblastoma (GB). A total of 47 patients with treatment-naive GB (M/F: 23/24, mean age: 54 years, age range: 20–90… read more here.
Keywords: contrast perfusion; genomic alterations; analysis; susceptibility contrast ... See more keywords
The Genomics of Prostate Cancer: emerging understanding with technologic advances
Sign Up to like & getrecommendations! Published in 2018 at "Modern Pathology"
DOI: 10.1038/modpathol.2017.166
Abstract: With the advent of next-generation sequencing technologies and large whole-exome and genome studies in prostate and other cancers, our understanding of the landscape of genomic alterations has dramatically been refined. In additional to well-known alterations… read more here.
Keywords: genomic alterations; genomics prostate; cancer emerging; prostate cancer ... See more keywords
Genomic alterations and evolution of cell clusters in metastatic invasive micropapillary carcinoma of the breast
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DOI: 10.1038/s41467-021-27794-4
Abstract: Invasive micropapillary carcinoma (IMPC) has very high rates of lymphovascular invasion and lymph node metastasis and has been reported in several organs. However, the genomic mechanisms underlying its metastasis are unclear. Here, we perform whole-genome… read more here.
Keywords: micropapillary carcinoma; lymph node; invasive micropapillary; cell clusters ... See more keywords
Comparative study on the induction of complex genomic alterations after exposure of mammalian cells to carboplatin and oxaliplatin
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DOI: 10.1080/01480545.2016.1252918
Abstract: Abstract Metal complexes are still broadly used as the first line of the treatment for different types of tumors nowadays. Carboplatin and oxaliplatin were authorized for clinical use, even though there is little information on… read more here.
Keywords: genomic alterations; complex genomic; induction complex; study ... See more keywords
Unique genomic features in adolescent and young adult, as compared to older adult, non‐Hodgkin lymphoma and potential therapeutic targets
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DOI: 10.1111/bjh.14157
Abstract: Non-Hodgkin lymphoma (NHL) can occur at any age, and is common in adolescents and young adults (AYA, age 15–39 years). The clinical outcome of AYA NHL can differ compared to younger and older populations. Treatment… read more here.
Keywords: genomic alterations; adult; age; alk fusions ... See more keywords
Central nervous system aspergillosis resembling haemorrhagic brain infarct in a paediatric leukaemia patient
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DOI: 10.1111/bjh.14161
Abstract: Additional Supporting Information may be found in the online version of this article: Fig S1. Long tail distribution of genomic alterations in 75 AYA NHLs. Fig S2. Tile plot of genomic alterations in 75 AYA… read more here.
Keywords: system aspergillosis; genomic alterations; nervous system; central nervous ... See more keywords
Genomic landscape of treatment‐naïve urological cancers using next‐generation sequencing‐based panel test in the Japanese population
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Urology"
DOI: 10.1111/iju.14927
Abstract: The top three urologic cancers in terms of mortality are PC (3.8%), bladder cancer (2.1%), and kidney cancer (2.1%) among all cancers in 2020. 1 The determination of therapeutic sensi-tivity based on genomic alteration has… read more here.
Keywords: genomic alterations; landscape; urological cancers; treatment ... See more keywords
Definition of a Novel Cuproptosis-Relevant lncRNA Signature for Uncovering Distinct Survival, Genomic Alterations, and Treatment Implications in Lung Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Immunology Research"
DOI: 10.1155/2022/2756611
Abstract: Objective Cuproptosis is a newly discovered copper-independent cell death modality, and limited evidence suggests the critical implications in human cancers. Nonetheless, the clinical impacts of cuproptosis-relevant lncRNAs in lung adenocarcinoma (LUAD) remain largely ill-defined. The… read more here.
Keywords: cuproptosis; relevant lncrna; genomic alterations; cuproptosis relevant ... See more keywords
Concordance of Genomic Alterations by Next-Generation Sequencing in Tumor Tissue versus Circulating Tumor DNA in Breast Cancer
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DOI: 10.1158/1535-7163.mct-17-0061
Abstract: While identifying genomic alterations in tumor tissue is the current gold-standard technique for molecular profiling, circulating tumor DNA (ctDNA) represents a noninvasive method of assessing genomic alterations using peripheral blood. The concordance of genomic alterations… read more here.
Keywords: genomic alterations; concordance genomic; tissue; cancer ... See more keywords