Challenges and Opportunities of Genomic Approaches in Therapeutics Development.
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DOI: 10.1007/978-1-0716-0849-4_7
Abstract: The magnitude of all therapeutic responses is significantly determined by genome structure, variation, and functional interactions. This determination occurs at many levels which are discussed in the current review. Well-established examples of structural variation between… read more here.
Keywords: approaches therapeutics; opportunities genomic; challenges opportunities; therapeutics development ... See more keywords
Pan-Genomic Approaches in Lactobacillus reuteri as a Porcine Probiotic: Investigation of Host Adaptation and Antipathogenic Activity
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DOI: 10.1007/s00248-017-0977-z
Abstract: After the introduction of a ban on the use of antibiotic growth promoters (AGPs) for livestock, reuterin-producing Lactobacillus reuteri is getting attention as an alternative to AGPs. In this study, we investigated genetic features of… read more here.
Keywords: lactobacillus reuteri; group; genomic approaches; host ... See more keywords
Current breeding and genomic approaches to enhance the cane and sugar productivity under abiotic stress conditions
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DOI: 10.1007/s13205-020-02416-w
Abstract: Sugarcane (Saccharum spp.) crop is vulnerable to many abiotic stresses such as drought, salinity, waterlogging, cold and high temperature due to climate change. Over the past few decades new breeding and genomic approaches have been… read more here.
Keywords: stress conditions; sugarcane; stress; genomic approaches ... See more keywords
Genomic approaches used to investigate an atypical outbreak of Salmonella Adjame
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DOI: 10.1099/mgen.0.000248
Abstract: In 2017, an outbreak of gastroenteritis in England attributed to Salmonella Adjame was detected and investigated. With the introduction of whole genome sequencing (WGS) for microbial typing, methods for comparing international outbreak data require evaluation.… read more here.
Keywords: approaches used; salmonella; salmonella adjame; adjame ... See more keywords
Parallel Genomics Uncover Novel Enterococcal-Bacteriophage Interactions
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DOI: 10.1128/mbio.03120-19
Abstract: We lack fundamental understanding of how phage infection influences bacterial gene expression and, consequently, how bacterial responses to phage infection affect the assembly of polymicrobial communities. Using parallel genomic approaches, we have discovered novel transcriptional… read more here.
Keywords: transcriptomic profiling; profiling phage; phage; genomic approaches ... See more keywords
Abstract IA05: Genomic approaches to drug discovery
Sign Up to like & getrecommendations! Published in 2018 at "Omics A Journal of Integrative Biology"
DOI: 10.1158/1557-3265.sarcomas17-ia05
Abstract: It is now becoming possible to bring powerful genomic methods to bear on the process of drug discovery. This talk will illustrate 1) the use of the Connectivity Map, a large-scale effort to develop a… read more here.
Keywords: abstract ia05; drug; discovery; genomic approaches ... See more keywords
Primer in Genetics and Genomics, Article 2—Advancing Nursing Research With Genomic Approaches
Sign Up to like & getrecommendations! Published in 2017 at "Biological Research For Nursing"
DOI: 10.1177/1099800416689822
Abstract: Purpose: Nurses investigate reasons for variable patient symptoms and responses to treatments to inform how best to improve outcomes. Genomics has the potential to guide nursing research exploring contributions to individual variability. This article is… read more here.
Keywords: research; genetics; genetics genomics; genomic approaches ... See more keywords
Novel insights in bacterial vaginosis etiology through genomic approaches.
Sign Up to like & getrecommendations! Published in 2021 at "Anais da Academia Brasileira de Ciencias"
DOI: 10.1590/0001-3765202120200945
Abstract: Bacterial vaginosis (BV) has been considered as dysbiosis state whose etiology is not fully understood. This condition affects a large number of women of reproductive age and its study has been highly relevant due to… read more here.
Keywords: etiology; bacterial vaginosis; genomic approaches; novel insights ... See more keywords
Pharmacological and Genomic Approaches in Management of Cystic Fibrosis.
Sign Up to like & getrecommendations! Published in 2020 at "Critical reviews in eukaryotic gene expression"
DOI: 10.1615/critreveukaryotgeneexpr.2020030845
Abstract: Cystic fibrosis (CF) is an inherited recessive autosomal disorder that affects the lungs, the digestive system, and secretory glands. It is a lethal condition caused by a mutation in the gene cystic-fibrosis-transmembrane-conductance- regulator (CFTR), which… read more here.
Keywords: cystic fibrosis; genomic approaches; cftr gene; gene ... See more keywords
Genomic Approaches to Uncovering the Coevolutionary History of Parasitic Lice
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DOI: 10.3390/life12091442
Abstract: Simple Summary New sequencing technologies have now made it possible to sequence entire genomes for a diversity of life on earth. Parasites comprise nearly half of all species. Lice are one important group of parasites… read more here.
Keywords: birds mammals; group parasites; lice; parasitic lice ... See more keywords