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Published in 2018 at "Nature Neuroscience"
DOI: 10.1038/s41593-018-0240-z
Abstract: The field of neurodegenerative disease research has seen tremendous advances over the last two decades as new technologies and analytic methods have enabled well-powered human genomic studies. Driven first by genetic studies and more recently…
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Keywords:
genomic architecture;
targeting genomic;
architecture human;
disease ... See more keywords
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Published in 2019 at "Briefings in Functional Genomics"
DOI: 10.1093/bfgp/elz008
Abstract: Abstract Plasmodium falciparum and Plasmodium vivax, the two protozoan parasite species that cause the majority of cases of human malaria, have developed resistance to nearly all known antimalarials. The ability of malaria parasites to develop…
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Keywords:
genomic architecture;
drug resistance;
antimalarial drug;
resistance ... See more keywords
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Published in 2022 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evac090
Abstract: Falcons are diverse birds of cultural and economic importance. They have undergone major lineage-specific chromosomal rearrangements, resulting in greatly-reduced chromosome counts relative to other birds. Here, we use 10X Genomics linked reads to provide new…
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Keywords:
falcon genomes;
linked read;
chromosomal rearrangements;
genomic architecture ... See more keywords
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Published in 2017 at "Plant and Cell Physiology"
DOI: 10.1093/pcp/pcx002
Abstract: To identify the similarities among responses to diverse environmental stresses, we analyzed the transcriptome response of rice roots to three rhizotoxic perturbations (chromium, ferulic acid and mercury) and identified common early-transient, early-constant and delayed gene…
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Keywords:
genomic architecture;
response;
delayed response;
early transient ... See more keywords
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Published in 2022 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2021.0192
Abstract: Supergenes are tightly linked sets of loci that are inherited together and control complex phenotypes. While classical supergenes—governing traits such as wing patterns in Heliconius butterflies or heterostyly in Primula—have been studied since the Modern…
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Keywords:
form function;
connecting form;
genomic architecture;
supergenes connecting ... See more keywords
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Published in 2022 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2021.0209
Abstract: Supergenes are involved in adaptation in multiple organisms, but they are little known in humans. Genomic inversions are the most common mechanism of supergene generation and maintenance. Here, we review the information about two large…
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Keywords:
potential human;
functional effects;
effects potential;
inversion ... See more keywords
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Published in 2023 at "Molecular Ecology"
DOI: 10.1111/mec.16875
Abstract: Organisms often acquire physiological and morphological modifications to conquer ecological challenges when colonizing new environments which lead to their adaptive evolution. However, deciphering the genomic mechanism of ecological adaptation is difficult because ecological environments are…
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Keywords:
songbird;
adaptation;
genomic architecture;
physiological adaptation ... See more keywords
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Published in 2020 at "Science"
DOI: 10.1126/science.aaz3017
Abstract: Untangling the genetics of plasticity The common buckeye butterfly, Junonia coenia, exhibits plastic coloration; it has two color morphs, light tan and dark red, that depend on day length and temperature. By selecting for more…
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Keywords:
genomic architecture;
trait;
color;
assimilated seasonal ... See more keywords
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Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0281159
Abstract: In this study, we explored the genomic architecture and phylogenomic relationship of BA.2.75, a subvariant of Omicron SARS-CoV-2. A set of 1468 whole-genome sequences of BA.2.75, submitted by 28 countries worldwide were retrieved from GISAID…
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Keywords:
relationship;
genomic architecture;
omicron sars;
subvariant omicron ... See more keywords
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Published in 2018 at "Genetics"
DOI: 10.1534/genetics.118.300894
Abstract: Phenotypic evolution and speciation depend on recombination in many ways. Within populations, recombination can promote adaptation by bringing together favorable mutations and decoupling beneficial and deleterious alleles. As populations diverge, crossing over can give rise…
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Keywords:
genomic architecture;
architecture rapid;
genetics;
genome ... See more keywords
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Published in 2019 at "Journal of dairy science"
DOI: 10.3168/jds.2018-15520
Abstract: Inbreeding depression is a growing concern in livestock because it can detrimentally affect animal fitness, health, and production levels. Genomic information can be used to more effectively capture variance in Mendelian sampling, thereby enabling more…
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Keywords:
genomic architecture;
symposium review;
information;
health ... See more keywords