Elevated pyrimidine dimer formation at distinct genomic bases underlies promoter mutation hotspots in UV-exposed cancers
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DOI: 10.1371/journal.pgen.1007849
Abstract: Sequencing of whole cancer genomes has revealed an abundance of recurrent mutations in gene-regulatory promoter regions, in particular in melanoma where strong mutation hotspots are observed adjacent to ETS-family transcription factor (TF) binding sites. While… read more here.
Keywords: mutation hotspots; elevated pyrimidine; promoter mutation; formation ... See more keywords