Genomic Biomarkers Predicting Response to Selective CDK4/6 Inhibition: Progress in an Elusive Search.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer cell"
DOI: 10.1016/j.ccell.2017.11.013
Abstract: In this issue of Cancer Cell, Gong et al. have analyzed the sensitivity of 560 cell lines to the selective CDK4/6 inhibitor abemaciclib and have defined cancers with specific genomic "D-cyclin activating features (DCAF)" as particularly… read more here.
Keywords: predicting response; cdk4; genomic biomarkers; response selective ... See more keywords
A Collaborative Initiative to Establish Genomic Biomarkers for Assessing Tumorigenic Potential to Reduce Reliance on Conventional Rodent Carcinogenicity Studies
Sign Up to like & getrecommendations! Published in 2022 at "Toxicological Sciences"
DOI: 10.1093/toxsci/kfac041
Abstract: Abstract There is growing recognition across broad sectors of the scientific community that use of genomic biomarkers has the potential to reduce the need for conventional rodent carcinogenicity studies of industrial chemicals, agrochemicals, and pharmaceuticals… read more here.
Keywords: carcinogenicity; rodent carcinogenicity; rodent; potential reduce ... See more keywords
Frequency of genomic biomarkers of response to immunotherapy in sarcoma.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.11579
Abstract: 11579Background: Recent data (D’Angelo et al, 2018) has suggested possible benefit for a subset of sarcoma patients from immune checkpoint inhibitors (ICPI). We assessed a large sarcoma population ... read more here.
Keywords: sarcoma; frequency genomic; biomarkers response; genomic biomarkers ... See more keywords
Actionable genomic biomarkers in a low socioeconomic status (SES) population with gastrointestinal (GI) cancers.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.15_suppl.e24310
Abstract: e24310Background: Immunotherapy and Precision Medicine therapy have increased survival in a minority of cancer patients. Genomic biomarkers that select for high tumor responders are not widely impl... read more here.
Keywords: actionable genomic; low socioeconomic; status ses; biomarkers low ... See more keywords
Genomic biomarkers in relation to PD-1 checkpoint blockade response.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2018.36.5_suppl.25
Abstract: 25Background: Somatic tumor mutational burden (TMB) and a T-cell inflamed gene expression profile (GEP) predict response to anti-PD-1/PD-L1 immunotherapies in multiple tumor types. We assessed the potential for GEP and TMB to jointly predict clinical… read more here.
Keywords: gep low; response; genomic biomarkers; tmb ... See more keywords
Identification of host genomic biomarkers from multiple transcriptomics datasets for diagnosis and therapies of SARS-CoV-2 infections
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DOI: 10.1371/journal.pone.0281981
Abstract: The pandemic of COVID-19 is a severe threat to human life and the global economy. Despite the success of vaccination efforts in reducing the spread of the virus, the situation remains largely uncontrolled due to… read more here.
Keywords: cov infections; hsa mir; genomic biomarkers; host genomic ... See more keywords
Genomic Biomarkers of Survival in Patients with Adenocarcinoma of the Uterine Cervix Receiving Chemoradiotherapy
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DOI: 10.3390/ijms21114117
Abstract: This study investigated the prognostic effects of genomic biomarkers for predicting chemoradiotherapy (CRT)-based treatment outcomes in patients with adenocarcinoma (AC) of the uterine cervix. In all, 21 patients receiving definitive CRT were included. In accordance… read more here.
Keywords: adenocarcinoma uterine; cervix receiving; patients adenocarcinoma; genomic biomarkers ... See more keywords
Genomic Transcriptome Benefits and Potential Harms of COVID-19 Vaccines Indicated from Optimized Genomic Biomarkers
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DOI: 10.3390/vaccines10111774
Abstract: COVID-19 vaccines can be the tugboats for preventing SARS-CoV-2 infections when they are practical and, more importantly, without adverse effects. However, the reality is that they may result in short-term or long-term impacts on COVID-19-related… read more here.
Keywords: adverse effects; covid vaccines; genomic biomarkers; expression values ... See more keywords