Myofibrillar myopathy in the genomic context
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Applied Genetics"
DOI: 10.1007/s13353-018-0463-4
Abstract: Myofibrillar myopathy (MFM) is a group of inherited muscular disorders characterized by myofibril dissolution and abnormal accumulation of degradation products. The diagnosis of muscular disorders based on clinical presentation is difficult due to phenotypic heterogeneity… read more here.
Keywords: myofibrillar myopathy; myopathy genomic; heterogeneity; genomic context ... See more keywords
MetaCherchant: analyzing genomic context of antibiotic resistance genes in gut microbiota
Sign Up to like & getrecommendations! Published in 2018 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btx681
Abstract: Motivation Antibiotic resistance is an important global public health problem. Human gut microbiota is an accumulator of resistance genes potentially providing them to pathogens. It is important to develop tools for identifying the mechanisms of… read more here.
Keywords: genomic context; resistance; gut microbiota; antibiotic resistance ... See more keywords
Dual functions of TET1 in germ layer lineage bifurcation distinguished by genomic context and dependence on 5-methylcytosine oxidation.
Sign Up to like & getrecommendations! Published in 2023 at "Nucleic acids research"
DOI: 10.1093/nar/gkad231
Abstract: Gastrulation begins when the epiblast forms the primitive streak or becomes definitive ectoderm. During this lineage bifurcation, the DNA dioxygenase TET1 has bipartite functions in transcriptional activation and repression, but the mechanisms remain unclear. By… read more here.
Keywords: tet1; dual functions; genomic context; lineage bifurcation ... See more keywords
Genomic Context and Mechanisms of the ACVR1 Mutation in Fibrodysplasia Ossificans Progressiva
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DOI: 10.3390/biomedicines9020154
Abstract: Basic research in Fibrodysplasia Ossificans Progressiva (FOP) was carried out in the various fields involved in the disease pathophysiology and was important for designing therapeutic approaches, some of which were already developed as ongoing or… read more here.
Keywords: fibrodysplasia ossificans; genomic context; context mechanisms; mutation ... See more keywords