Genomic, epigenomic, and transcriptomic signatures for telomerase complex components: a pan‐cancer analysis
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13324
Abstract: Telomerase activation is required for malignant transformation. Recent advances in high‐throughput technologies have enabled the generation of complex datasets, thus providing alternative approaches to exploring telomerase biology more comprehensively, which has proven to be challenging… read more here.
Keywords: telomerase; telomerase activity; genomic epigenomic; pan cancer ... See more keywords
Same-day genomic and epigenomic diagnosis of brain tumors using real-time nanopore sequencing
Sign Up to like & getrecommendations! Published in 2017 at "Acta Neuropathologica"
DOI: 10.1007/s00401-017-1743-5
Abstract: Molecular classification of cancer has entered clinical routine to inform diagnosis, prognosis, and treatment decisions. At the same time, new tumor entities have been identified that cannot be defined histologically. For central nervous system tumors,… read more here.
Keywords: diagnosis; genomic epigenomic; time; nanopore sequencing ... See more keywords
Integrative analysis of genomic and epigenomic regulation of the transcriptome in liver cancer
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00991-w
Abstract: Hepatocellular carcinoma harbors numerous genomic and epigenomic aberrations of DNA copy numbers and DNA methylation. Transcriptomic deregulation by these aberrations plays key driver roles in heterogeneous progression of cancers. Here, we profile DNA copy numbers,… read more here.
Keywords: hepatocellular carcinoma; integrative analysis; genomic epigenomic; analysis genomic ... See more keywords
Genomic and Epigenomic Aberrations in Esophageal Squamous Cell Carcinoma and Implications for Patients.
Sign Up to like & getrecommendations! Published in 2018 at "Gastroenterology"
DOI: 10.1053/j.gastro.2017.06.066
Abstract: Esophageal squamous cell carcinoma (ESCC) is a common malignancy without effective therapy. The exomes of more than 600 ESCCs have been sequenced in the past 4 years, and numerous key aberrations have been identified. Recently,… read more here.
Keywords: cell carcinoma; squamous cell; genomic epigenomic; epigenomic aberrations ... See more keywords
Genomic and epigenomic responses to aspirin in human colonic organoids.
Sign Up to like & getrecommendations! Published in 2023 at "Physiological genomics"
DOI: 10.1152/physiolgenomics.00070.2022
Abstract: BACKGROUND Aspirin (ASA) is a proven chemoprotective agent for colorectal cancer, though mechanisms underlying these effects are incompletely understood. Human organoids are an ideal system to study genomic and epigenomic host-environment interactions. We utilize human… read more here.
Keywords: human colonic; colonic organoids; genomic epigenomic; epigenomic responses ... See more keywords
Elucidation of the Genomic-Epigenomic Interaction Landscape of Aggressive Prostate Cancer
Sign Up to like & getrecommendations! Published in 2021 at "BioMed Research International"
DOI: 10.1155/2021/6641429
Abstract: Background Majority of prostate cancer (PCa) deaths are attributed to localized high-grade aggressive tumours which progress rapidly to metastatic disease. A critical unmet need in clinical management of PCa is discovery and characterization of the… read more here.
Keywords: aggressive pca; genomic epigenomic; prostate cancer; pca ... See more keywords
Genomic and Epigenomic Features of Glioblastoma Multiforme and its Biomarkers
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Oncology"
DOI: 10.1155/2022/4022960
Abstract: Glioblastoma multiforme is a serious and life-threatening tumor of central nervous system, characterized by aggressive behavior, poor prognosis, and low survival rate. Despite of the availability of aggressive antitumor therapeutic regimen for glioblastoma (radiotherapy followed… read more here.
Keywords: multiforme biomarkers; prognosis; genomic epigenomic; features glioblastoma ... See more keywords
Dynamics of genomic, epigenomic, and transcriptomic aberrations during stepwise hepatocarcinogenesis.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer research"
DOI: 10.1158/0008-5472.can-19-0991
Abstract: Hepatocellular carcinoma (HCC) undergoes a stepwise progression from liver cirrhosis (LC) to low-grade dysplastic nodule (LGDN), high-grade dysplastic nodule (HGDN), early HCC (eHCC), and progressed HCC (pHCC). Here, we profiled multi-layered genomic, epigenomic, and transcriptomic… read more here.
Keywords: genomic epigenomic; transcriptomic aberrations; epigenomic transcriptomic; hepatocarcinogenesis ... See more keywords
Abstract B012: Genomic and epigenomic drivers of double-negative metastatic prostate cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.prca2023-b012
Abstract: Systemic targeted therapy in prostate cancer is primarily focused on ablating androgen receptor (AR) signaling. Androgen deprivation therapy and second-generation AR-targeted therapy selectively favor the development of treatment-resistant subtypes of metastatic castration-resistant prostate cancer (mCRPC),… read more here.
Keywords: double negative; prostate cancer; genomic epigenomic; drivers double ... See more keywords
Abstract IA002: Genomic and epigenomic regulation during prostate cancer progression
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.prca2023-ia002
Abstract: Prostate cancer (PCa) development and progression are controlled by aberrant expression, mutation, and function of essential transcriptional factors and epigenetic modifiers. Over the years, our work has delineated the molecular mechanisms by which androgen receptor… read more here.
Keywords: prostate cancer; genomic epigenomic; progression; cancer progression ... See more keywords
Genomic and Epigenomic Characterization of Tumor Organoid Models
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14174090
Abstract: Simple Summary The patient-derived organoid (PDO) model is a versatile and dynamic tool for investigating individual genomic and epigenomic properties of cancer. PDOs preserve key (epi-)genomic features and maintain physiological and pathological characteristics, resembling patient… read more here.
Keywords: oncology; genomic epigenomic; organoid modeling; tumor organoid ... See more keywords