Genomic evolution and the impact of SLIT2 mutation in relapsed intrahepatic cholangiocarcinoma.
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.32164
Abstract: BACKGROUND & AIMS Intrahepatic cholangiocarcinoma (ICC) is aggressive and has high rates of relapse, conferring poor long-term survival after curative resection. Little is known about the genomic evolution that occurs during ICC relapse. APPROACH &… read more here.
Keywords: evolution; intrahepatic cholangiocarcinoma; genomic evolution; mutation ... See more keywords
Genomic evolution of the Coronaviridae family
Sign Up to like & getrecommendations! Published in 2022 at "Virology"
DOI: 10.1016/j.virol.2022.03.005
Abstract: The current outbreak of coronavirus disease-2019 (COVID-19) caused by SARS-CoV-2 poses unparalleled challenges to global public health. SARS-CoV-2 is a Betacoronavirus, one of four genera belonging to the Coronaviridae subfamily Orthocoronavirinae. Coronaviridae, in turn, are… read more here.
Keywords: genomic evolution; coronaviridae family; evolution; evolution coronaviridae ... See more keywords
Circulating tumor DNA analysis depicts subclonal architecture and genomic evolution of small cell lung cancer
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DOI: 10.1038/s41467-018-05327-w
Abstract: Subclonal architecture and genomic evolution of small-cell lung cancer (SCLC) under treatment has not been well studied primarily due to lack of tumor specimens, particularly longitudinal samples acquired during treatment. SCLC is characterized by early… read more here.
Keywords: genomic evolution; treatment; subclonal architecture; tumor ... See more keywords
Elevated APE1 dysregulates homologous recombination and cell cycle driving genomic evolution, tumorigenesis and chemoresistance in esophageal adenocarcinoma.
Sign Up to like & getrecommendations! Published in 2023 at "Gastroenterology"
DOI: 10.1053/j.gastro.2023.04.035
Abstract: BACKGROUND AND AIMS Purpose of this study was to identify drivers of genomic evolution in esophageal adenocarcinoma (EAC) and other solid tumors. METHODS An integrated genomics strategy was used to identify deoxyribonucleases correlating with genomic… read more here.
Keywords: cell; instability; cell cycle; genomic evolution ... See more keywords
Contrasting Genomic Evolution Between Domesticated and Wild Kluyveromyces lactis Yeast Populations
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DOI: 10.1093/gbe/evad004
Abstract: The process of domestication has variable consequences on genome evolution leading to different phenotypic signatures. Access to the complete genome sequences of a large number of individuals makes it possible to explore the different facets… read more here.
Keywords: domestication; kluyveromyces lactis; contrasting genomic; lactis yeast ... See more keywords
Genomic evolution of uveal melanoma arising in ocular melanocytosis
Sign Up to like & getrecommendations! Published in 2019 at "Cold Spring Harbor Molecular Case Studies"
DOI: 10.1101/mcs.a004051
Abstract: Ocular melanocytosis is the most important predisposing condition for the eye cancer uveal melanoma (UM). Here, we present a patient who developed UM arising within ocular melanocytosis who was treated with enucleation (eye removal), which… read more here.
Keywords: ocular melanocytosis; uveal melanoma; genomic evolution; melanoma arising ... See more keywords
Rapid, nonparallel genomic evolution of Brassica rapa (field mustard) under experimental drought
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Evolutionary Biology"
DOI: 10.1111/jeb.14152
Abstract: While we know that climate change can potentially cause rapid phenotypic evolution, our understanding of the genetic basis and degree of genetic parallelism of rapid evolutionary responses to climate change is limited. In this study,… read more here.
Keywords: experimental drought; genomic evolution; brassica rapa; evolution ... See more keywords
Genomic evolution and diverse models of systemic metastases in colorectal cancer
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DOI: 10.1136/gutjnl-2020-323703
Abstract: Objective The systemic spread of colorectal cancer (CRC) is dominated by the portal system and exhibits diverse patterns of metastasis without systematical genomic investigation. Here, we evaluated the genomic evolution of CRC with multiorgan metastases… read more here.
Keywords: colorectal cancer; metastasis; genomic evolution; crc ... See more keywords
Abstract 1169: Genomic evolution of pancreatic cancer at single-cell resolution
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-1169
Abstract: As the breadth of genomic sequencing datasets increases, we can engage more directly with the evolutionary principles governing cancer progression. But as clonal evolution happens at the single-cell level, one must rely on strong assumptions… read more here.
Keywords: resolution; single cell; genomic evolution; cancer ... See more keywords
The Genomic Evolution and the Transmission Dynamics of H6N2 Avian Influenza A Viruses in Southern China
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DOI: 10.3390/v14061154
Abstract: In China, the broad prevalence of H6 subtype influenza viruses, increasingly detected in aquatic birds, promotes their exchange materials with other highly pathogenic human-infecting H5N1, H5N6, and H7N9 influenza viruses. Strikingly, some H6 subtype viruses… read more here.
Keywords: influenza viruses; influenza; transmission; genomic evolution ... See more keywords
Tracking the Genomic Evolution of SARS-CoV-2 for 29 Months in South Korea
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DOI: 10.3390/v15040873
Abstract: The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has continued, with the persistent emergence of variants of concern (VOCs). Therefore, this study aimed to track the genomic evolution of SARS-CoV-2 strains… read more here.
Keywords: south korea; tracking genomic; evolution sars; genomic evolution ... See more keywords