Genomic heterogeneity contributed to different prognosis between adult and pediatric acute lymphoblastic
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.5a0721-361r
Abstract: The prognosis of acute lymphoblastic leukemia (ALL) in adults is inferior to that in children. Hence, ALL remains challenging to cure in the adult population. Aberrant genetic alterations have been observed in ALL, although the… read more here.
Keywords: prognosis; adult; adult pediatric; acute lymphoblastic ... See more keywords
Genomic heterogeneity in myeloproliferative neoplasms and applications to clinical practice.
Sign Up to like & getrecommendations! Published in 2020 at "Blood reviews"
DOI: 10.1016/j.blre.2020.100708
Abstract: The myeloproliferative neoplasms (MPN) polycythaemia vera, essential thrombocythaemia and primary myelofibrosis are chronic myeloid disorders associated most often with mutations in JAK2, MPL and CALR, and in some patients with additional acquired genomic lesions. Whilst… read more here.
Keywords: genomic heterogeneity; clinical practice; neoplasms applications; heterogeneity myeloproliferative ... See more keywords
Simultaneous evolutionary expansion and constraint of genomic heterogeneity in multifocal lung cancer
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DOI: 10.1038/s41467-017-00963-0
Abstract: Recent genomic analyses have revealed substantial tumor heterogeneity across various cancers. However, it remains unclear whether and how genomic heterogeneity is constrained during tumor evolution. Here, we sequence a unique cohort of multiple synchronous lung… read more here.
Keywords: genomic heterogeneity; heterogeneity; expansion constraint; constraint genomic ... See more keywords
MP51-01 PREVALENCE OF COLLISION TUMORS IN PROSTATE CANCER AS A MODEL FOR INTRAFOCAL GENOMIC HETEROGENEITY
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Urology"
DOI: 10.1097/ju.0000000000000913.01
Abstract: INTRODUCTION AND OBJECTIVE: Prostate cancer is a multifocal disease with distinct molecular subtypes. However, the utility of genomic subclassification has been challenged due to the high degree of interand intra-focal heterogeneity. We sought to analyze… read more here.
Keywords: collision tumors; prostate cancer; genomic heterogeneity; cancer ... See more keywords
Abstract A041: Development of novel in-vitro mixed-cell models to capture genomic heterogeneity in prostate tumors
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.prca2023-a041
Abstract: Prostate cancer (PC), especially castration resistant PC (CRPC), is known to exhibit a high degree of intra- and inter-tumoral (inter-individual) heterogeneity, which have been linked to treatment resistance and disease recurrence. Yet, models employed for… read more here.
Keywords: cell; heterogeneity; development; cell lines ... See more keywords
Genomic Heterogeneity as a Barrier to Precision Medicine in Gastroesophageal Adenocarcinoma.
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DOI: 10.1158/2159-8290.cd-17-0395
Abstract: Gastroesophageal adenocarcinoma (GEA) is a lethal disease where targeted therapies, even when guided by genomic biomarkers, have had limited efficacy. A potential reason for the failure of such therapies is that genomic profiling results could… read more here.
Keywords: medicine; precision medicine; genomic heterogeneity; heterogeneity ... See more keywords
Genomic heterogeneity underlies multidrug resistance in Pseudomonas aeruginosa: A population-level analysis beyond susceptibility testing
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DOI: 10.1371/journal.pone.0265129
Abstract: Background Pseudomonas aeruginosa is a persistent and difficult-to-treat pathogen in many patients, especially those with Cystic Fibrosis (CF). Herein, we describe a longitudinal analysis of a series of multidrug resistant (MDR) P. aeruginosa isolates recovered… read more here.
Keywords: pseudomonas aeruginosa; susceptibility testing; analysis; resistance ... See more keywords
Genomic Heterogeneity of Pancreatic Ductal Adenocarcinoma and Its Clinical Impact
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DOI: 10.3390/cancers13174451
Abstract: Simple Summary Although much progress has been made in recent years in the clinical management of solid tumors, pancreatic ductal adenocarcinoma (PDAC) remains a malignancy with limited therapeutical options. Indeed, responses to standard chemotherapy and… read more here.
Keywords: genomic heterogeneity; pdac; impact; pancreatic ductal ... See more keywords