Interleukin 6–dependent genomic instability heralds accelerated carcinogenesis following liver regeneration on a background of chronic hepatitis
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.29004
Abstract: Liver cancer, which typically develops on a background of chronic liver inflammation, is now the second leading cause of cancer mortality worldwide. For patients with liver cancer, surgical resection is a principal treatment modality that… read more here.
Keywords: background chronic; liver regeneration; genomic instability; hepatology ... See more keywords
Genomic Instability of iPSCs and Challenges in Their Clinical Applications.
Sign Up to like & getrecommendations! Published in 2019 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-31206-0_2
Abstract: Generation of human-induced pluripotent stem cells (iPSCs) from somatic cells has opened the possibility to design novel therapeutic approaches. In 2014, the first-in-human clinical trial of iPSC-based therapy was conducted. However, the transplantation for the… read more here.
Keywords: ipscs challenges; genetic aberrations; genomic instability; instability ipscs ... See more keywords
Integrin-Linked-Kinase Overexpression Is Implicated in Mechanisms of Genomic Instability in Human Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Digestive Diseases and Sciences"
DOI: 10.1007/s10620-020-06364-6
Abstract: Background Genomic instability is a hallmark of cancer cells contributing to tumor development and progression. Integrin-linked kinase (ILK) is a focal adhesion protein with well-established role in carcinogenesis. We have previously shown that ILK overexpression… read more here.
Keywords: overexpression; genomic instability; ilk; ilk overexpression ... See more keywords
Genomic instability as a major mechanism for acquired resistance to EGFR tyrosine kinase inhibitors in cancer
Sign Up to like & getrecommendations! Published in 2021 at "Protein & Cell"
DOI: 10.1007/s13238-021-00855-6
Abstract: The mutation-mediated overexpression of epidermal growth factor receptor tyrosine kinase (EGFR TK) and its activation play an important role in the cellular proliferation and epithelial tumorigenesis. A series of inhibitors targeting the intracellular tyrosine kinase… read more here.
Keywords: cancer; egfr; tyrosine kinase; genomic instability ... See more keywords
SEI1 induces genomic instability by inhibiting DNA damage response in ovarian cancer.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer letters"
DOI: 10.1016/j.canlet.2016.09.032
Abstract: Previous studies have shown that the oncogene SEI1 is highly expressed in ovarian carcinomas, and promoting genomic instability. However, the molecular mechanism of SEI1 in promoting genomic instability remains unclear. We observed SEI1 overexpression in… read more here.
Keywords: dna damage; genomic instability; sei1; ovarian cancer ... See more keywords
Long noncoding RNA: A resident staff of genomic instability regulation in tumorigenesis.
Sign Up to like & getrecommendations! Published in 2021 at "Cancer letters"
DOI: 10.1016/j.canlet.2021.01.021
Abstract: Genomic instability is an important characteristic of cancer, which promotes clonal evolution and tumorigenesis by increasing the frequency of gene destruction and loss of genome integrity. Generally, the maintenance of genomic stability depends significantly on… read more here.
Keywords: long noncoding; genomic instability; tumorigenesis; noncoding rna ... See more keywords
Lack of superoxide dismutase in a rad51 mutant exacerbates genomic instability and oxidative stress‐mediated cytotoxicity in Saccharomyces cerevisiae
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.09.015
Abstract: &NA; A genetic analysis of synthetic lethal interactions in yeast revealed that the mutation of SOD1, encoding an antioxidant enzyme that scavenges superoxide anion radical, impaired the growth of a set of mutants defective in… read more here.
Keywords: genomic instability; saccharomyces cerevisiae; sod1; deficiency ... See more keywords
Elevated somatic mutation and evidence of genomic instability in veterans with gulf war illness.
Sign Up to like & getrecommendations! Published in 2021 at "Life sciences"
DOI: 10.1016/j.lfs.2021.119746
Abstract: AIMS Gulf War illness (GWI) is thought to be associated with exposures experienced by soldiers deployed in the 1991 Gulf War. A major question is how these exposures continue to influence the health of these… read more here.
Keywords: gulf war; somatic mutation; genomic instability; mutation ... See more keywords
Genome-wide Map of R-Loop-Induced Damage Reveals How a Subset of R-Loops Contributes to Genomic Instability.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.06.037
Abstract: DNA-RNA hybrids associated with R-loops promote DNA damage and genomic instability. The capacity of hybrids at different genomic sites to cause DNA damage was not known, and the mechanisms leading from hybrid to damage were… read more here.
Keywords: genome wide; genomic instability; map; induced damage ... See more keywords
CtIP-Mediated Fork Protection Synergizes with BRCA1 to Suppress Genomic Instability upon DNA Replication Stress.
Sign Up to like & getrecommendations! Published in 2018 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.09.014
Abstract: Protecting stalled DNA replication forks from degradation by promiscuous nucleases is essential to prevent genomic instability, a major driving force of tumorigenesis. Several proteins commonly associated with the repair of DNA double-strand breaks (DSBs) by… read more here.
Keywords: ctip; dna replication; replication; genomic instability ... See more keywords
Phosphatidylinositol 3-Kinase (PI3K) δ blockade increases genomic instability in B cells
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature21406
Abstract: Activation-induced cytidine deaminase (AID) is a B-cell-specific enzyme that targets immunoglobulin genes to initiate class switch recombination and somatic hypermutation. In addition, through off-target activity, AID has a much broader effect on genomic instability by… read more here.
Keywords: expression; phosphatidylinositol kinase; genomic instability; aid ... See more keywords