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   Articles with "genomic integrity" as a keyword



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A Regulatory Role for RUNX1, RUNX3 in the Maintenance of Genomic Integrity.

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recommendations! Published in 2017 at "Advances in experimental medicine and biology"

DOI: 10.1007/978-981-10-3233-2_29

Abstract: All human cells are constantly attacked by endogenous and exogenous agents that damage the integrity of their genomes. Yet, the ensuing damage is mostly fixed and very rarely gives rise to genomic defects that promote… read more here.

Keywords: dna damage; integrity; genomic integrity; runx1 runx3 ... See more keywords
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Loss of genomic integrity induced by lysosphingolipid imbalance drives ageing in the heart

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recommendations! Published in 2019 at "EMBO reports"

DOI: 10.15252/embr.201847407

Abstract: Cardiac dysfunctions dramatically increase with age. Revealing a currently unknown contributor to cardiac ageing, we report the age‐dependent, cardiac‐specific accumulation of the lysosphingolipid sphinganine (dihydrosphingosine, DHS) as an evolutionarily conserved hallmark of the aged vertebrate… read more here.

Keywords: loss genomic; heart; integrity induced; induced lysosphingolipid ... See more keywords
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Specialized Circuitry of Embryonic Stem Cells Promotes Genomic Integrity.

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recommendations! Published in 2022 at "Critical reviews in oncogenesis"

DOI: 10.1615/critrevoncog.2022042332

Abstract: Embryonic stem cells (ESCs) give rise to all cell types of the organism. Given the importance of these cells in this process, ESCs must employ robust mechanisms to protect genomic integrity or risk catastrophic propagation… read more here.

Keywords: embryonic stem; genomic integrity; stem cells; specialized circuitry ... See more keywords
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Contribution of integrin adhesion to cytokinetic abscission and genomic integrity

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recommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"

DOI: 10.3389/fcell.2022.1048717

Abstract: Recent research shows that integrin-mediated adhesion contributes to the regulation of cell division at two key steps: the formation of the mitotic spindle at the mitotic entry and the final cytokinetic abscission at the mitotic… read more here.

Keywords: contribution integrin; adhesion; genomic integrity; cytokinetic abscission ... See more keywords