Genomic landscape of follicular lymphoma across a wide spectrum of clinical behaviors.
Sign Up to like & getrecommendations! Published in 2023 at "Hematological oncology"
DOI: 10.1002/hon.3132
Abstract: While some follicular lymphoma (FL) patients do not require treatment or experience prolonged responses, others relapse early, and little is known about genetic alterations specific to patients with a particular clinical behavior. We selected 56… read more here.
Keywords: lymphoma; genomic landscape; relapse; follicular lymphoma ... See more keywords
Genomic landscape of microsatellite instability in Chinese tumors: A comparison of Chinese and TCGA cohorts
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Cancer"
DOI: 10.1002/ijc.34119
Abstract: Microsatellite instability (MSI) is an important biomarker for predicting the response to immunotherapy and prognosis that mainly results from a defective DNA mismatch repair (MMR) system and strongly correlates with high tumor mutation burden (TMB).… read more here.
Keywords: msi; microsatellite instability; genomic landscape; instability ... See more keywords
Comparative insight into the genomic landscape of SARS‐CoV‐2 and identification of mutations associated with the origin of infection and diversity
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Medical Virology"
DOI: 10.1002/jmv.26744
Abstract: The analyses of 2325 severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) genomes revealed 107, 162, and 65 nucleotide substitutions in the coding region of SARS‐CoV‐2 from the three continents America, Europe, and Asia, respectively. Of these… read more here.
Keywords: insight genomic; comparative insight; nucleotide substitutions; spike ... See more keywords
The Genomic Landscape of Endocrine-Resistant Advanced Breast Cancers.
Sign Up to like & getrecommendations! Published in 2018 at "Cancer cell"
DOI: 10.1016/j.ccell.2018.08.008
Abstract: We integrated the genomic sequencing of 1,918 breast cancers, including 1,501 hormone receptor-positive tumors, with detailed clinical information and treatment outcomes. In 692 tumors previously exposed to hormonal therapy, we identified an increased number of… read more here.
Keywords: breast cancers; genomic landscape; endocrine resistant; landscape endocrine ... See more keywords
Genomic landscape characterization of large granular lymphocyte leukemia with a systems genetics approach
Sign Up to like & getrecommendations! Published in 2017 at "Leukemia"
DOI: 10.1038/leu.2017.49
Abstract: Genomic landscape characterization of large granular lymphocyte leukemia with a systems genetics approach read more here.
Keywords: characterization large; genetics; granular lymphocyte; large granular ... See more keywords
The genomic landscape of tuberous sclerosis complex
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms15816
Abstract: Tuberous sclerosis complex (TSC) is a rare genetic disease causing multisystem growth of benign tumours and other hamartomatous lesions, which leads to diverse and debilitating clinical symptoms. Patients are born with TSC1 or TSC2 mutations,… read more here.
Keywords: sclerosis complex; tuberous sclerosis; tsc; genomic landscape ... See more keywords
THE GENOMIC LANDSCAPE OF PEDIATRIC AND YOUNG ADULT T-LINEAGE ACUTE LYMPHOBLASTIC LEUKEMIA
Sign Up to like & getrecommendations! Published in 2017 at "Nature genetics"
DOI: 10.1038/ng.3909
Abstract: Genetic alterations that activate NOTCH1 signaling and T cell transcription factors, coupled with inactivation of the INK4/ARF tumor suppressors, are hallmarks of T-lineage acute lymphoblastic leukemia (T-ALL), but detailed genome-wide sequencing of large T-ALL cohorts… read more here.
Keywords: lineage acute; genomic landscape; acute lymphoblastic; lymphoblastic leukemia ... See more keywords
The evolving genomic landscape of urothelial carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Nature Reviews Urology"
DOI: 10.1038/nrurol.2017.11
Abstract: Survival of patients with urothelial carcinoma (including bladder cancer and upper tract urothelial carcinoma) is limited by our current approaches to staging, surgery, and chemotherapy. Large-scale, next-generation sequencing collaborations, such as The Cancer Genome Atlas,… read more here.
Keywords: carcinoma; landscape urothelial; evolving genomic; urothelial carcinoma ... See more keywords
Genomic landscape and genetic manipulation of the black soldier fly Hermetia illucens, a natural waste recycler
Sign Up to like & getrecommendations! Published in 2019 at "Cell Research"
DOI: 10.1038/s41422-019-0252-6
Abstract: The black soldier fly (BSF), Hermetia illucens (Diptera: Stratiomyidae), is renowned for its bioconversion of organic waste into a sustainable source of animal feed. We report a high-quality genome of 1.1 Gb and a consensus set… read more here.
Keywords: black soldier; waste; soldier fly; hermetia illucens ... See more keywords
Genomic landscape and chronological reconstruction of driver events in multiple myeloma
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-11680-1
Abstract: The multiple myeloma (MM) genome is heterogeneous and evolves through preclinical and post-diagnosis phases. Here we report a catalog and hierarchy of driver lesions using sequences from 67 MM genomes serially collected from 30 patients… read more here.
Keywords: driver events; events multiple; multiple myeloma; landscape chronological ... See more keywords
Genomic landscape of platinum resistant and sensitive testicular cancers
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-15768-x
Abstract: While most testicular germ cell tumours (TGCTs) exhibit exquisite sensitivity to platinum chemotherapy, ~10% are platinum resistant. To gain insight into the underlying mechanisms, we undertake whole exome sequencing and copy number analysis in 40… read more here.
Keywords: platinum; copy number; landscape platinum; platinum resistant ... See more keywords