Articles with "genomic profiling" as a keyword



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Genomic Profiling of Small-Bowel Adenocarcinoma

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Published in 2017 at "JAMA Oncology"

DOI: 10.1001/jamaoncol.2017.1051

Abstract: Importance Small-bowel adenocarcinomas (SBAs) are rare cancers with a significantly lower incidence, later stage at diagnosis, and worse overall survival than other intestinal-derived cancers. To date, comprehensive genomic analysis of SBA is lacking. Objective To… read more here.

Keywords: small bowel; colorectal cancer; genomic profiling; sba ... See more keywords
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Genomic profiling of newly diagnosed glioblastoma patients and its potential for clinical utility – a prospective, translational study

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Published in 2020 at "Molecular Oncology"

DOI: 10.1002/1878-0261.12790

Abstract: Glioblastoma (GBM) is an incurable brain tumor for which new treatment strategies are urgently needed. Next‐generation sequencing of GBM has most often been performed retrospectively and on archival tissue from both diagnostic and relapse surgeries… read more here.

Keywords: glioblastoma; newly diagnosed; treatment; study ... See more keywords
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Diverse EGFR Exon 20 Insertions and Co‐Occurring Molecular Alterations Identified by Comprehensive Genomic Profiling of NSCLC

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Published in 2018 at "Journal of Thoracic Oncology"

DOI: 10.1016/j.jtho.2018.06.019

Abstract: Introduction: EGFR exon 20 insertions (EGFRex20ins) comprise an uncommon subset of EGFR‐activating alterations relatively insensitive to first‐ and second‐generation EGFR tyrosine kinase inhibitors (TKIs). However, recent early clinical data suggests these patients may benefit from… read more here.

Keywords: generation egfr; egfr; comprehensive genomic; egfr exon ... See more keywords
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Genomic Profiling and Metabolic Homeostasis in Primary Liver Cancers.

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Published in 2018 at "Trends in molecular medicine"

DOI: 10.1016/j.molmed.2018.02.006

Abstract: Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA), the two most common primary liver cancers, represent the second most common cancer-related cause of death worldwide, with most cases being diagnosed at an advanced stage. Recent genome-wide… read more here.

Keywords: metabolic homeostasis; liver; primary liver; profiling metabolic ... See more keywords
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Psychological impact of comprehensive tumor genomic profiling results for advanced cancer patients.

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Published in 2022 at "Patient education and counseling"

DOI: 10.1016/j.pec.2022.01.011

Abstract: OBJECTIVE Comprehensive tumor genomic profiling (CTGP) is increasingly used to personalize treatments, providing hope, but potentially disappointment, for patients. We explored psychological outcomes in patients with advanced, incurable cancer, after receiving CTGP results. METHODS Participants… read more here.

Keywords: cancer; comprehensive tumor; actionable results; advanced cancer ... See more keywords
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Variant call concordance between two laboratory-developed, solid tumor targeted genomic profiling assays using distinct workflows and sequencing instruments.

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Published in 2017 at "Experimental and molecular pathology"

DOI: 10.1016/j.yexmp.2017.02.002

Abstract: Targeted genomic profiling (TGP) using massively parallel DNA sequencing is becoming the standard methodology in clinical laboratories for detecting somatic variants in solid tumors. The variety of methodologies and sequencing platforms in the marketplace for… read more here.

Keywords: solid tumor; targeted genomic; genomic profiling; laboratory ... See more keywords
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Genomic profiling of advanced cervical cancer to predict response to PD-1 inhibitor combination therapy: a secondary analysis of the CLAP trial

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Published in 2021 at "Gynecologic Oncology"

DOI: 10.1016/s0090-8258(21)00698-3

Abstract: Objectives: The CLAP trial (NCT03816553) is a multicenter, single-arm, phase II study in patients with metastatic, recurrent, or persistent cervical cancer who were treated with PD-1 inhibitor camrelizumab plus a VEGFR2 inhibitor apatinib. In this… read more here.

Keywords: inhibitor; cervical cancer; genomic profiling; cancer ... See more keywords
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Costs of in-house genomic profiling and implications for economic evaluation: a case example of non-small cell lung cancer (NSCLC)

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Published in 2020 at "Journal of Medical Economics"

DOI: 10.1080/13696998.2020.1789152

Abstract: Abstract Objectives Genomic profiling in oncology is vital for determining eligible patients for mutation-specific targeted therapies. Use of commercial genomic testing has the potential to improve patient outcomes. Economic evaluations of in-house genomic profiling typically… read more here.

Keywords: non material; house; material costs; genomic profiling ... See more keywords
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Liquidhope: methylome and genomic profiling from very limited quantities of plasma-derived DNA

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Published in 2023 at "Briefings in Bioinformatics"

DOI: 10.1093/bib/bbac575

Abstract: Abstract Analysis of the methylome of tumor cell-free deoxyribonucleic acid (DNA; cfDNA) has emerged as a powerful non-invasive technique for cancer subtyping and prognosis. However, its application is frequently hampered by the quality and total… read more here.

Keywords: methylome genomic; genomic profiling; limited quantities; quantities plasma ... See more keywords
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Comparative chemical genomic profiling across plant-based hydrolysate toxins reveals widespread antagonism in fitness contributions

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Published in 2022 at "FEMS Yeast Research"

DOI: 10.1093/femsyr/foac036

Abstract: Abstract The budding yeast Saccharomyces cerevisiae has been used extensively in fermentative industrial processes, including biofuel production from sustainable plant-based hydrolysates. Myriad toxins and stressors found in hydrolysates inhibit microbial metabolism and product formation. Overcoming… read more here.

Keywords: genomic profiling; plant based; comparative chemical; profiling across ... See more keywords
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Genomic Profiling of Vulvar Lichen Sclerosus Patients Shows Possible Pathogenetic Disease Mechanisms.

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Published in 2019 at "Journal of Lower Genital Tract Disease"

DOI: 10.1097/lgt.0000000000000482

Abstract: OBJECTIVE Vulvar lichen sclerosus (LS) is known to occur in families, suggesting a genetic link. Genomic profiling of patients with vulvar LS was investigated to find underlying pathogenetic mechanisms, with the hope that targeted therapies… read more here.

Keywords: genomic profiling; lichen sclerosus; vulvar lichen; family ... See more keywords