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Published in 2017 at "JAMA Oncology"
DOI: 10.1001/jamaoncol.2017.1051
Abstract: Importance Small-bowel adenocarcinomas (SBAs) are rare cancers with a significantly lower incidence, later stage at diagnosis, and worse overall survival than other intestinal-derived cancers. To date, comprehensive genomic analysis of SBA is lacking. Objective To…
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Keywords:
small bowel;
colorectal cancer;
genomic profiling;
sba ... See more keywords
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Published in 2020 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12790
Abstract: Glioblastoma (GBM) is an incurable brain tumor for which new treatment strategies are urgently needed. Next‐generation sequencing of GBM has most often been performed retrospectively and on archival tissue from both diagnostic and relapse surgeries…
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Keywords:
glioblastoma;
newly diagnosed;
treatment;
study ... See more keywords
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Published in 2018 at "Journal of Thoracic Oncology"
DOI: 10.1016/j.jtho.2018.06.019
Abstract: Introduction: EGFR exon 20 insertions (EGFRex20ins) comprise an uncommon subset of EGFR‐activating alterations relatively insensitive to first‐ and second‐generation EGFR tyrosine kinase inhibitors (TKIs). However, recent early clinical data suggests these patients may benefit from…
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Keywords:
generation egfr;
egfr;
comprehensive genomic;
egfr exon ... See more keywords
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Published in 2018 at "Trends in molecular medicine"
DOI: 10.1016/j.molmed.2018.02.006
Abstract: Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (iCCA), the two most common primary liver cancers, represent the second most common cancer-related cause of death worldwide, with most cases being diagnosed at an advanced stage. Recent genome-wide…
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Keywords:
metabolic homeostasis;
liver;
primary liver;
profiling metabolic ... See more keywords
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Published in 2022 at "Patient education and counseling"
DOI: 10.1016/j.pec.2022.01.011
Abstract: OBJECTIVE Comprehensive tumor genomic profiling (CTGP) is increasingly used to personalize treatments, providing hope, but potentially disappointment, for patients. We explored psychological outcomes in patients with advanced, incurable cancer, after receiving CTGP results. METHODS Participants…
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Keywords:
cancer;
comprehensive tumor;
actionable results;
advanced cancer ... See more keywords
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Published in 2017 at "Experimental and molecular pathology"
DOI: 10.1016/j.yexmp.2017.02.002
Abstract: Targeted genomic profiling (TGP) using massively parallel DNA sequencing is becoming the standard methodology in clinical laboratories for detecting somatic variants in solid tumors. The variety of methodologies and sequencing platforms in the marketplace for…
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Keywords:
solid tumor;
targeted genomic;
genomic profiling;
laboratory ... See more keywords
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Published in 2021 at "Gynecologic Oncology"
DOI: 10.1016/s0090-8258(21)00698-3
Abstract: Objectives: The CLAP trial (NCT03816553) is a multicenter, single-arm, phase II study in patients with metastatic, recurrent, or persistent cervical cancer who were treated with PD-1 inhibitor camrelizumab plus a VEGFR2 inhibitor apatinib. In this…
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Keywords:
inhibitor;
cervical cancer;
genomic profiling;
cancer ... See more keywords
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Published in 2020 at "Journal of Medical Economics"
DOI: 10.1080/13696998.2020.1789152
Abstract: Abstract Objectives Genomic profiling in oncology is vital for determining eligible patients for mutation-specific targeted therapies. Use of commercial genomic testing has the potential to improve patient outcomes. Economic evaluations of in-house genomic profiling typically…
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Keywords:
non material;
house;
material costs;
genomic profiling ... See more keywords
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Published in 2023 at "Briefings in Bioinformatics"
DOI: 10.1093/bib/bbac575
Abstract: Abstract Analysis of the methylome of tumor cell-free deoxyribonucleic acid (DNA; cfDNA) has emerged as a powerful non-invasive technique for cancer subtyping and prognosis. However, its application is frequently hampered by the quality and total…
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Keywords:
methylome genomic;
genomic profiling;
limited quantities;
quantities plasma ... See more keywords
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Published in 2022 at "FEMS Yeast Research"
DOI: 10.1093/femsyr/foac036
Abstract: Abstract The budding yeast Saccharomyces cerevisiae has been used extensively in fermentative industrial processes, including biofuel production from sustainable plant-based hydrolysates. Myriad toxins and stressors found in hydrolysates inhibit microbial metabolism and product formation. Overcoming…
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Keywords:
genomic profiling;
plant based;
comparative chemical;
profiling across ... See more keywords
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Published in 2019 at "Journal of Lower Genital Tract Disease"
DOI: 10.1097/lgt.0000000000000482
Abstract: OBJECTIVE Vulvar lichen sclerosus (LS) is known to occur in families, suggesting a genetic link. Genomic profiling of patients with vulvar LS was investigated to find underlying pathogenetic mechanisms, with the hope that targeted therapies…
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Keywords:
genomic profiling;
lichen sclerosus;
vulvar lichen;
family ... See more keywords