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Published in 2021 at "Acta Diabetologica"
DOI: 10.1007/s00592-020-01650-1
Abstract: Type 2 diabetes (T2D) is affected by a combination of genetic and environmental factors. However, the comprehensive genomic risk scores (GRSs) for T2D prediction have not been evaluated. Using a meta-scoring approach, we developed a…
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Keywords:
genomic risk;
risk score;
type diabetes;
risk ... See more keywords
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Published in 2021 at "Breast Cancer Research and Treatment"
DOI: 10.1007/s10549-021-06429-8
Abstract: Genomic expression assays provide prognostic information and guide adjuvant chemotherapy decisions for patients with estrogen receptor (ER)-positive breast cancer. Few studies have evaluated the utility of such assays for invasive lobular carcinoma (ILC). The objective…
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Keywords:
risk;
genomic risk;
breast cancer;
gene ... See more keywords
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Published in 2019 at "Cancer epidemiology"
DOI: 10.1016/j.canep.2019.05.002
Abstract: BACKGROUND Exposure to ultraviolet radiation from sunlight is directly associated with melanoma skin cancer, however reducing sun-exposure can be difficult to achieve at a population level. METHODS Using a genomic risk information behaviour change trial…
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Keywords:
melanoma;
risk;
information;
genomic risk ... See more keywords
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Published in 2018 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2018.07.079
Abstract: Background Coronary artery disease (CAD) has substantial heritability and a polygenic architecture. However, the potential of genomic risk scores to help predict CAD outcomes has not been evaluated comprehensively, because available studies have involved limited…
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Keywords:
risk;
genomic risk;
cad;
coronary artery ... See more keywords
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Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-13848-1
Abstract: Recent genome-wide association studies in stroke have enabled the generation of genomic risk scores (GRS) but their predictive power has been modest compared to established stroke risk factors. Here, using a meta-scoring approach, we develop…
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Keywords:
risk;
genomic risk;
risk score;
risk factors ... See more keywords
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Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2019789118
Abstract: Significance Environmental and genetic risk factors, and the early antecedents of schizophrenia, represent pieces of a puzzle still far from completion. We show that, in infants with a history of prenatal complications, a measure of…
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Keywords:
risk;
early neurodevelopmental;
genomic risk;
neurodevelopmental outcomes ... See more keywords
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Published in 2022 at "Stroke"
DOI: 10.1161/strokeaha.122.041701
Abstract: Background: Intracerebral hemorrhage (ICH) has an estimated heritability of 29%. We developed a genomic risk score for ICH and determined its predictive power in comparison to standard clinical risk factors. Methods: We combined genome-wide association…
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Keywords:
risk score;
risk factors;
risk;
clinical risk ... See more keywords
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Published in 2021 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2021.39.15_suppl.e12568
Abstract: e12568Background: Genomic risk of recurrence assays provide prognostic information that aids treatment recommendations for patients with early breast cancer (EBC). The 70-gene signature (MammaPrint...
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Keywords:
genomic risk;
gene;
breast cancer;
gene signature ... See more keywords
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Published in 2021 at "Cancers"
DOI: 10.3390/cancers13143533
Abstract: Simple Summary We designed a study specifically to assess the performance of genomic risk prediction for breast cancer (BC) in older women aged ≥70 years. We assessed the effects of a polygenic risk score (PRS)…
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Keywords:
risk;
prs;
aged years;
genomic risk ... See more keywords
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Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm12101704
Abstract: The evolution of polygenic scores for use in for disease prevention and control compels the development of guidelines to optimize their effectiveness and promote equitable use. Understanding the motivations and barriers to participation in genomics…
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Keywords:
barriers participation;
motivations barriers;
melanoma genomic;
trial ... See more keywords