Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function.
Sign Up to like & getrecommendations! Published in 2017 at "Cancer cell"
DOI: 10.1016/j.ccell.2017.09.002
Abstract: Proper organization of the mitotic spindle is key to genetic stability, but molecular components of inter-microtubule bridges that crosslink kinetochore fibers (K-fibers) are still largely unknown. Here we identify a kinase-independent function of class II… read more here.
Keywords: pi3k; breast cancer; genomic stability; stability ... See more keywords
Caspase-2 as a Master Regulator of Genomic Stability.
Sign Up to like & getrecommendations! Published in 2021 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2021.03.002
Abstract: Genomic instability underlies genesis and the development of various types of cancer. During tumorigenesis, cancer initiating cells assume a set of features, which allow them to survive and proliferate. Different mutations and chromosomal alterations promote… read more here.
Keywords: caspase; master regulator; genomic stability; caspase master ... See more keywords
Critical role of the POT1 OB domain in maintaining genomic stability
Sign Up to like & getrecommendations! Published in 2017 at "Oncogene"
DOI: 10.1038/onc.2016.365
Abstract: Oligonucleotide/oligosaccharide-binding (OB) domain-containing proteins have been identified as critical for telomere maintenance, DNA repair, transcription and other DNA metabolism processes. Protection of telomere 1 (POT1), a telomere binding protein, has an OB domain like single-strand… read more here.
Keywords: pot1 telomere; genomic stability; role; pot1 ... See more keywords
CtBP1/2 differentially regulate genomic stability and DNA repair pathway in high-grade serous ovarian cancer cell
Sign Up to like & getrecommendations! Published in 2021 at "Oncogenesis"
DOI: 10.1038/s41389-021-00344-9
Abstract: The C-terminal binding proteins (CtBPs), CtBP1 and CtBP2, are transcriptional co-repressor that interacts with multiple transcriptional factors to modulate the stability of chromatin. CtBP proteins were identified with overexpression in the high-grade serous ovarian carcinoma… read more here.
Keywords: serous ovarian; dna; stability dna; genomic stability ... See more keywords
PD-L1 regulates genomic stability via interaction with cohesin-SA1 in the nucleus
Sign Up to like & getrecommendations! Published in 2021 at "Signal Transduction and Targeted Therapy"
DOI: 10.1038/s41392-021-00463-0
Abstract: Dear Editor, Programmed death ligand-1 (PD-L1) is a type 1 transmembrane protein and highly expressed in various cancers that binds to PD-1 on T cells, inhibits T cell activity and proliferation, facilitates cancer cells to… read more here.
Keywords: supplementary fig; genomic stability; sa1; interaction ... See more keywords
A guanidine-degrading enzyme controls genomic stability of ethylene-producing cyanobacteria
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-25369-x
Abstract: Recent studies have revealed the prevalence and biological significance of guanidine metabolism in nature. However, the metabolic pathways used by microbes to degrade guanidine or mitigate its toxicity have not been widely studied. Here, via… read more here.
Keywords: ethylene; degrading enzyme; genomic stability; guanidine degrading ... See more keywords
Genomic stability through time despite decades of exploitation in cod on both sides of the Atlantic
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2025453118
Abstract: Significance Both theory and experiments suggest that fishing can drive the evolution of an earlier maturation age. However, determining whether changes in the wild are the result of fisheries-induced evolution has been difficult. Temporal, genome-wide… read more here.
Keywords: evolution; change; stability time; cod ... See more keywords
Linkage disequilibrium suggests genomic stability in omicron clades of SARS-CoV-2 from the ASEAN countries.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of travel medicine"
DOI: 10.1093/jtm/taad020
Abstract: Genome-wide population structure analyses showed the presence of linkage disequilibrium and low recombination rates in the SARS-CoV-2. read more here.
Keywords: linkage disequilibrium; suggests genomic; sars cov; genomic stability ... See more keywords
The Nexus of Endocrine Signaling and Cancer: How Steroid Hormones Influence Genomic Stability
Sign Up to like & getrecommendations! Published in 2021 at "Endocrinology"
DOI: 10.1210/endocr/bqaa177
Abstract: Abstract Endocrine-driven malignancies, including breast and prostate cancer, are among the most common human cancers. The relationship between sex steroid hormones (eg, androgen, estrogen, and progesterone), their cognate receptors, and genomic stability lie at the… read more here.
Keywords: cancer; genomic stability; nexus endocrine; steroid hormones ... See more keywords
Activating the Anaphase Promoting Complex to Enhance Genomic Stability and Prolong Lifespan
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms19071888
Abstract: In aging cells, genomic instability is now recognized as a hallmark event. Throughout life, cells encounter multiple endogenous and exogenous DNA damaging events that are mostly repaired, but inevitably DNA mutations, chromosome rearrangements, and epigenetic… read more here.
Keywords: anaphase promoting; genomic instability; response; genomic stability ... See more keywords