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   Articles with "genomic stability" as a keyword



Mitotic Spindle Assembly and Genomic Stability in Breast Cancer Require PI3K-C2α Scaffolding Function.

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recommendations! Published in 2017 at "Cancer cell"

DOI: 10.1016/j.ccell.2017.09.002

Abstract: Proper organization of the mitotic spindle is key to genetic stability, but molecular components of inter-microtubule bridges that crosslink kinetochore fibers (K-fibers) are still largely unknown. Here we identify a kinase-independent function of class II… read more here.

Keywords: pi3k; breast cancer; genomic stability; stability ... See more keywords

Caspase-2 as a Master Regulator of Genomic Stability.

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recommendations! Published in 2021 at "Trends in cell biology"

DOI: 10.1016/j.tcb.2021.03.002

Abstract: Genomic instability underlies genesis and the development of various types of cancer. During tumorigenesis, cancer initiating cells assume a set of features, which allow them to survive and proliferate. Different mutations and chromosomal alterations promote… read more here.

Keywords: caspase; master regulator; genomic stability; caspase master ... See more keywords

Associations of Serum Per- and Polyfluoroalkyl Substances with Genotoxic Biomarkers: New Insights from Cross-Sectional and In Vivo Evidence

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recommendations! Published in 2025 at "Environmental Science & Technology"

DOI: 10.1021/acs.est.5c02054

Abstract: The effects of perfluoroalkyl and polyfluoroalkyl substances (PFAS) on genomic stability remain unclear. Here, a cross-sectional study was conducted to establish the associations of PFAS with genotoxic biomarkers. We recruited a cohort of 453 residents… read more here.

Keywords: pfo5doda; cross sectional; polyfluoroalkyl substances; genomic stability ... See more keywords

Critical role of the POT1 OB domain in maintaining genomic stability

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recommendations! Published in 2017 at "Oncogene"

DOI: 10.1038/onc.2016.365

Abstract: Oligonucleotide/oligosaccharide-binding (OB) domain-containing proteins have been identified as critical for telomere maintenance, DNA repair, transcription and other DNA metabolism processes. Protection of telomere 1 (POT1), a telomere binding protein, has an OB domain like single-strand… read more here.

Keywords: pot1 telomere; genomic stability; role; pot1 ... See more keywords

CtBP1/2 differentially regulate genomic stability and DNA repair pathway in high-grade serous ovarian cancer cell

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recommendations! Published in 2021 at "Oncogenesis"

DOI: 10.1038/s41389-021-00344-9

Abstract: The C-terminal binding proteins (CtBPs), CtBP1 and CtBP2, are transcriptional co-repressor that interacts with multiple transcriptional factors to modulate the stability of chromatin. CtBP proteins were identified with overexpression in the high-grade serous ovarian carcinoma… read more here.

Keywords: serous ovarian; dna; stability dna; genomic stability ... See more keywords
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PD-L1 regulates genomic stability via interaction with cohesin-SA1 in the nucleus

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recommendations! Published in 2021 at "Signal Transduction and Targeted Therapy"

DOI: 10.1038/s41392-021-00463-0

Abstract: Dear Editor, Programmed death ligand-1 (PD-L1) is a type 1 transmembrane protein and highly expressed in various cancers that binds to PD-1 on T cells, inhibits T cell activity and proliferation, facilitates cancer cells to… read more here.

Keywords: supplementary fig; genomic stability; sa1; interaction ... See more keywords

A guanidine-degrading enzyme controls genomic stability of ethylene-producing cyanobacteria

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recommendations! Published in 2021 at "Nature Communications"

DOI: 10.1038/s41467-021-25369-x

Abstract: Recent studies have revealed the prevalence and biological significance of guanidine metabolism in nature. However, the metabolic pathways used by microbes to degrade guanidine or mitigate its toxicity have not been widely studied. Here, via… read more here.

Keywords: ethylene; degrading enzyme; genomic stability; guanidine degrading ... See more keywords
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Genomic stability through time despite decades of exploitation in cod on both sides of the Atlantic

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recommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2025453118

Abstract: Significance Both theory and experiments suggest that fishing can drive the evolution of an earlier maturation age. However, determining whether changes in the wild are the result of fisheries-induced evolution has been difficult. Temporal, genome-wide… read more here.

Keywords: evolution; change; stability time; cod ... See more keywords

Wdr5-mediated H3K4 methylation facilitates HSPC development via maintenance of genomic stability in zebrafish

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recommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2420534122

Abstract: Significance Hematopoietic stem and progenitor cells (HSPCs) undergo rapid proliferation during embryonic development, establishing the foundation for lifelong hematopoiesis. Genomic stability is crucial for HSPC proliferation; however, the precise regulation of genomic stability to ensure… read more here.

Keywords: mediated h3k4; stability; wdr5 mediated; h3k4 methylation ... See more keywords

Linkage disequilibrium suggests genomic stability in omicron clades of SARS-CoV-2 from the ASEAN countries.

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recommendations! Published in 2023 at "Journal of travel medicine"

DOI: 10.1093/jtm/taad020

Abstract: Genome-wide population structure analyses showed the presence of linkage disequilibrium and low recombination rates in the SARS-CoV-2. read more here.

Keywords: linkage disequilibrium; suggests genomic; sars cov; genomic stability ... See more keywords

KDM6A–SND1 interaction maintains genomic stability by protecting the nascent DNA and contributes to cancer chemoresistance

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recommendations! Published in 2024 at "Nucleic Acids Research"

DOI: 10.1093/nar/gkae487

Abstract: Abstract Genomic instability is one of the hallmarks of cancer. While loss of histone demethylase KDM6A increases the risk of tumorigenesis, its specific role in maintaining genomic stability remains poorly understood. Here, we propose a… read more here.

Keywords: interaction; kdm6a snd1; genomic stability; nascent dna ... See more keywords