Genomic and structural basis for evolution of tropane alkaloid biosynthesis.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2302448120
Abstract: The tropane alkaloids (TAs) cocaine and hyoscyamine have been used medicinally for thousands of years. To understand the evolutionary origins and trajectories of serial biosynthetic enzymes of TAs and especially the characteristic tropane skeletons, we… read more here.
Keywords: biosynthesis; genomic structural; structural basis; analysis ... See more keywords
Discovering and genotyping genomic structural variations by yeast genome synthesis and inducible evolution.
Sign Up to like & getrecommendations! Published in 2020 at "FEMS yeast research"
DOI: 10.1093/femsyr/foaa012
Abstract: Genomic structural variations (SVs) promote the evolution of Saccharomyces cerevisiae, and play an important role in phenotypic diversities. Yeast genomic structures can be remodeled by design and bottom-up synthesis. The synthesis of yeast genome creates… read more here.
Keywords: genomic structural; structural variations; yeast genome; inducible evolution ... See more keywords
Genetic risk shared across 24 chronic pain conditions: identification and characterization with genomic structural equation modeling.
Sign Up to like & getrecommendations! Published in 2023 at "Pain"
DOI: 10.1097/j.pain.0000000000002922
Abstract: ABSTRACT Chronic pain conditions frequently co-occur, suggesting common risks and paths to prevention and treatment. Previous studies have reported genetic correlations among specific groups of pain conditions and reported genetic risk for within-individual multisite pain… read more here.
Keywords: genomic structural; chronic pain; pain; pain conditions ... See more keywords
Genomic structural plasticity of rodent‐associated Bartonella in nature
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Ecology"
DOI: 10.1111/mec.16547
Abstract: Rodent‐associated Bartonella species have shown a remarkable genetic diversity and pathogenic potential. To further explore the extent of the natural intraspecific genomic variation and its potential role as an evolutionary driver, we focused on a… read more here.
Keywords: structural plasticity; genomic structural; plasticity rodent; rodent associated ... See more keywords
GOOGA: A platform to synthesize mapping experiments and identify genomic structural diversity
Sign Up to like & getrecommendations! Published in 2019 at "PLoS Computational Biology"
DOI: 10.1371/journal.pcbi.1006949
Abstract: Understanding genomic structural variation such as inversions and translocations is a key challenge in evolutionary genetics. We develop a novel statistical approach to comparative genetic mapping to detect large-scale structural mutations from low-level sequencing data.… read more here.
Keywords: platform synthesize; genomic structural; mapping; googa ... See more keywords
Clade II Candida auris possess genomic structural variations related to an ancestral strain
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0223433
Abstract: Candida auris is an invasive and multidrug-resistant ascomycetous yeast that is under global surveillance. All clinical cases of C. auris infection diagnosed from 1997 to 2019 in Japan were non-invasive and sporadic otitis media cases.… read more here.
Keywords: genomic structural; structural variations; candida auris; clade ... See more keywords
The shared genetic architecture of suicidal behaviour and psychiatric disorders: A genomic structural equation modelling study
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2023.1083969
Abstract: Background: Suicidal behaviour (SB) refers to behaviours, ranging from non-fatal suicidal behaviour, such as suicidal ideation and attempt, to completed suicide. Despite recent advancements in genomic technology and statistical methods, it is unclear to what… read more here.
Keywords: behaviour psychiatric; psychiatric disorders; shared genetic; genomic structural ... See more keywords
SARS-CoV CH.1.1 Variant: Genomic and Structural Insight
Sign Up to like & getrecommendations! Published in 2023 at "Infectious Disease Reports"
DOI: 10.3390/idr15030029
Abstract: In early February 2023, the Omicron subvariant XBB.1.5, also known as “Kraken”, accounted for more than 44% of new COVID-19 cases worldwide, whereas a relatively new Omicron subvariant named CH.1.1, deemed “Orthrus”, accounted for less… read more here.
Keywords: cov variant; variant genomic; structural insight; genomic structural ... See more keywords