Genomic Studies Reveal New Aspects of the Biology of DNA Damaging Agents
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700520
Abstract: A flurry of papers has appeared recently to force a rethinking of our understanding of how chemicals, light, and metal complexes damage our genomes. Conventional wisdom was that damaging agents were indiscriminate and it was… read more here.
Keywords: genomic studies; dna damaging; studies reveal; biology ... See more keywords
Multiple hypothesis screening using mixtures of non‐local distributions with applications to genomic studies
Sign Up to like & getrecommendations! Published in 2022 at "Statistics in Medicine"
DOI: 10.1002/sim.9705
Abstract: The analysis of large‐scale datasets, especially in biomedical contexts, frequently involves a principled screening of multiple hypotheses. The celebrated two‐group model jointly models the distribution of the test statistics with mixtures of two competing densities,… read more here.
Keywords: using mixtures; genomic studies; hypothesis screening; non local ... See more keywords
Fibroblasts as an in vitro model of circadian genetic and genomic studies
Sign Up to like & getrecommendations! Published in 2024 at "Mammalian Genome"
DOI: 10.1007/s00335-024-10050-7
Abstract: Bipolar disorder (BD) is a heritable disorder characterized by shifts in mood that manifest in manic or depressive episodes. Clinical studies have identified abnormalities of the circadian system in BD patients as a hallmark of… read more here.
Keywords: vitro model; genetic architecture; genomic studies; model ... See more keywords
The functional genomic studies of resveratrol in respect to its anti-cancer effects.
Sign Up to like & getrecommendations! Published in 2018 at "Biotechnology advances"
DOI: 10.1016/j.biotechadv.2018.02.011
Abstract: Resveratrol has anti-cancer effects in vitro, and hypothetical chemopreventive effects in vivo. Effects are pleiotropic, mediated by changes in expression of many genes and epigenetic reprogramming. Thus, they are well suited for functional genomic studies.… read more here.
Keywords: genomic studies; cancer effects; functional genomic; anti cancer ... See more keywords
The functional genomic studies of curcumin.
Sign Up to like & getrecommendations! Published in 2017 at "Seminars in cancer biology"
DOI: 10.1016/j.semcancer.2017.04.002
Abstract: Curcumin is a natural plant-derived compound that has attracted a lot of attention for its anti-cancer activities. Curcumin can slow proliferation of and induce apoptosis in cancer cell lines, but the precise mechanisms of these… read more here.
Keywords: genomic studies; functional genomic; studies curcumin; cancer ... See more keywords
Genetic and genomic studies of pathogenic EXOSC2 mutations in the newly described disease SHRF implicate the autophagy pathway in disease pathogenesis.
Sign Up to like & getrecommendations! Published in 2019 at "Human molecular genetics"
DOI: 10.1093/hmg/ddz251
Abstract: Missense mutations in the RNA exosome component Exosome Component 2 (EXOSC2), also known as Ribosomal RNA-processing Protein 4 (RRP4), were recently identified in two unrelated families with a novel syndrome known as Short stature, Hearing… read more here.
Keywords: genomic studies; shrf; pathogenesis; fly rrp4 ... See more keywords
TVIR: a comprehensive vegetable information resource database for comparative and functional genomic studies
Sign Up to like & getrecommendations! Published in 2022 at "Horticulture Research"
DOI: 10.1093/hr/uhac213
Abstract: Abstract Vegetables are an indispensable part of the daily diet of humans. Therefore, it is vital to systematically study the genomic data of vegetables and build a platform for data sharing and analysis. In this… read more here.
Keywords: information; genomic studies; database; information resource ... See more keywords
A molecular toolkit to boost functional genomic studies in transformation-recalcitrant vegetable legumes
Sign Up to like & getrecommendations! Published in 2023 at "Horticulture Research"
DOI: 10.1093/hr/uhad064
Abstract: © The Author(s) 2023. Published by Oxford University Press on behalf of Nanjing Agricultural University. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted… read more here.
Keywords: toolkit boost; genomic studies; horticulture; boost functional ... See more keywords
Abstract 2269: Factors associated with declining to participate in cancer genetic and genomic studies among Hispanic/Latine patients with colorectal cancer: findings from a Cancer MoonshotSMproject
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DOI: 10.1158/1538-7445.am2025-2269
Abstract: Colorectal cancer (CRC) is the third leading cause of cancer-related mortality among Hispanic/Latine (H/L) men and women in the United States (US), yet H/L patients are underrepresented in cancer genetic/genomic studies. As part of the… read more here.
Keywords: colorectal cancer; cancer; genetic genomic; genomic studies ... See more keywords
Informed consent in genetic and genomic studies in Sub-Saharan Africa: a systematic review of bioethical issues
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DOI: 10.1186/s12910-025-01170-z
Abstract: International collaboration on genetic/genomic studies has expanded dramatically. Informed consent remains a cornerstone for protecting participant autonomy. Over the past few decades, guidelines, recommendations, and theoretical discussions have been published on the informed consent process… read more here.
Keywords: consent; bioethical issues; genetic genomic; genomic studies ... See more keywords
A Review of African Americans’ Beliefs and Attitudes About Genomic Studies: Opportunities for Message Design
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2019.00548
Abstract: Precision Medicine, the practice of targeting prevention and therapies according to an individual’s lifestyle, environment or genetics, holds promise to improve population health outcomes. Within precision medicine, pharmacogenomics (PGX) uses an individual’s genome to determine… read more here.
Keywords: medicine; genomic studies; african americans; opportunities message ... See more keywords