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   Articles with "genomic transcriptomic" as a keyword



Targeted therapy of advanced parathyroid carcinoma guided by genomic and transcriptomic profiling.

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recommendations! Published in 2023 at "Molecular oncology"

DOI: 10.1002/1878-0261.13398

Abstract: Parathyroid carcinoma (PC) is an ultra-rare malignancy with a high risk of recurrence after surgery. Tumor-directed systemic treatments for PC are not established. We used whole-genome and RNA sequencing in four patients with advanced PC… read more here.

Keywords: targeted therapy; advanced parathyroid; parathyroid carcinoma; therapy advanced ... See more keywords

Clinical, genomic, and transcriptomic differences between myelodysplastic syndrome/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis (MDS/MPN‐RS‐T) and myelodysplastic syndrome with ring sideroblasts (MDS‐RS)

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recommendations! Published in 2021 at "American Journal of Hematology"

DOI: 10.1002/ajh.26182

Abstract: REFERENCES 1. Kumar SK, Callander NS, Hillengass J, et al. NCCN guidelines insights: multiple myeloma, version 1.2020. J Natl Compr Canc Netw. 2019;17 (10):1154-1165. 2. Cheson BD, Leoni L. Bendamustine: mechanism of action and clinical… read more here.

Keywords: genomic transcriptomic; ring sideroblasts; multiple myeloma; myelodysplastic syndrome ... See more keywords
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Genomic, transcriptomic and physiological analyses of silver‐resistant Saccharomyces cerevisiae obtained by evolutionary engineering

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recommendations! Published in 2020 at "Yeast"

DOI: 10.1002/yea.3514

Abstract: Silver is a non‐essential metal used in medical applications as an antimicrobial agent, but it is also toxic for biological systems. To investigate the molecular basis of silver resistance in yeast, we employed evolutionary engineering… read more here.

Keywords: genomic transcriptomic; evolutionary engineering; saccharomyces cerevisiae; analysis results ... See more keywords

A comparative genomic and transcriptomic analysis at the level of isolated root hair cells reveals new conserved root hair regulatory elements

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recommendations! Published in 2017 at "Plant Molecular Biology"

DOI: 10.1007/s11103-017-0630-8

Abstract: Key messageA comparative transcriptomic and genomic analysis between Arabidopsis thaliana and Glycine max root hair genes reveals the evolution of the expression of plant genes after speciation and whole genome duplication.AbstractOur understanding of the conservation… read more here.

Keywords: genomic transcriptomic; plant; analysis; hair ... See more keywords
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Machine learning analysis using 77,044 genomic and transcriptomic profiles to accurately predict tumor type

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recommendations! Published in 2021 at "Translational Oncology"

DOI: 10.1016/j.tranon.2021.101016

Abstract: Highlights • CUP occurs in as many as 3–5% of patients when standard diagnostic tests are not able to determine the origin of cancer.• MI GPSai (Genomic Prevalence Score) is an AI that uses genomic… read more here.

Keywords: genomic transcriptomic; learning analysis; machine learning; tumor type ... See more keywords

Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma

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recommendations! Published in 2019 at "Nature Communications"

DOI: 10.1038/s41467-019-08578-3

Abstract: Burkitt lymphoma (BL) is the most common B-cell lymphoma in children. Within the International Cancer Genome Consortium (ICGC), we performed whole genome and transcriptome sequencing of 39 sporadic BL. Here, we unravel interaction of structural, mutational,… read more here.

Keywords: genomic transcriptomic; lymphoma; pathogenesis; burkitt lymphoma ... See more keywords

Multi-omic and single-cell profiling of chromothriptic medulloblastoma reveals genomic and transcriptomic consequences of genome instability

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recommendations! Published in 2024 at "Nature Communications"

DOI: 10.1038/s41467-024-54547-w

Abstract: Chromothripsis is a frequent form of genome instability, whereby a presumably single catastrophic event generates extensive genomic rearrangements of one or multiple chromosome(s). However, little is known about the heterogeneity of chromothripsis across different clones… read more here.

Keywords: genomic transcriptomic; chromothripsis; genome instability; single cell ... See more keywords

Genomic, transcriptomic, and immunogenomic landscape of over 1300 sarcomas of diverse histology subtypes

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-58678-6

Abstract: Given their rarity and diversity, a fundamental understanding of the genomic underpinnings for many sarcoma subtypes is still lacking. To better define the molecular landscape of this group of diseases, we perform matched whole exome… read more here.

Keywords: immunogenomic landscape; histology; landscape 1300; genomic transcriptomic ... See more keywords

Overlap of Genomic and Transcriptomic Genes Identified in Familial Eosinophilic Esophagitis.

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recommendations! Published in 2025 at "Gastroenterology"

DOI: 10.1053/j.gastro.2025.01.235

Abstract: BACKGROUND AND AIMS Evidence for a genetic contribution to eosinophilic esophagitis (EoE) exists from family and genome-wide association studies. Extensive investigation into rare variants contributing to EoE has not been performed. The study aim is… read more here.

Keywords: genes identified; family; eosinophilic esophagitis; family members ... See more keywords

Genomic and transcriptomic characterization of the Collimonas quorum sensing genes and regulon.

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recommendations! Published in 2022 at "FEMS microbiology ecology"

DOI: 10.1093/femsec/fiac100

Abstract: Collimonads are well adapted to nutrient-poor environments. They are known to hydrolyse chitin, produce antifungal metabolites, weather minerals, and are effective biocontrol agents protecting plants from fungal diseases. The production of N-acyl homoserine lactones (AHLs)… read more here.

Keywords: collimonas quorum; ecology; characterization collimonas; quorum sensing ... See more keywords

An integrative overview of genomic, transcriptomic and proteomic analyses in organohalide respiration research

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recommendations! Published in 2018 at "FEMS Microbiology Ecology"

DOI: 10.1093/femsec/fiy013

Abstract: ABSTRACT Organohalide respiration (OHR) is a crucial process in the global halogen cycle and of interest for bioremediation. However, investigations on OHR are hampered by the restricted genetic accessibility and the poor growth yields of… read more here.

Keywords: genomic transcriptomic; respiration; organohalide respiration; integrative overview ... See more keywords