Targeted therapy of advanced parathyroid carcinoma guided by genomic and transcriptomic profiling.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular oncology"
DOI: 10.1002/1878-0261.13398
Abstract: Parathyroid carcinoma (PC) is an ultra-rare malignancy with a high risk of recurrence after surgery. Tumor-directed systemic treatments for PC are not established. We used whole-genome and RNA sequencing in four patients with advanced PC… read more here.
Keywords: targeted therapy; advanced parathyroid; parathyroid carcinoma; therapy advanced ... See more keywords
Clinical, genomic, and transcriptomic differences between myelodysplastic syndrome/myeloproliferative neoplasm with ring sideroblasts and thrombocytosis (MDS/MPN‐RS‐T) and myelodysplastic syndrome with ring sideroblasts (MDS‐RS)
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Hematology"
DOI: 10.1002/ajh.26182
Abstract: REFERENCES 1. Kumar SK, Callander NS, Hillengass J, et al. NCCN guidelines insights: multiple myeloma, version 1.2020. J Natl Compr Canc Netw. 2019;17 (10):1154-1165. 2. Cheson BD, Leoni L. Bendamustine: mechanism of action and clinical… read more here.
Keywords: genomic transcriptomic; ring sideroblasts; multiple myeloma; myelodysplastic syndrome ... See more keywords
Genomic, transcriptomic and physiological analyses of silver‐resistant Saccharomyces cerevisiae obtained by evolutionary engineering
Sign Up to like & getrecommendations! Published in 2020 at "Yeast"
DOI: 10.1002/yea.3514
Abstract: Silver is a non‐essential metal used in medical applications as an antimicrobial agent, but it is also toxic for biological systems. To investigate the molecular basis of silver resistance in yeast, we employed evolutionary engineering… read more here.
Keywords: genomic transcriptomic; evolutionary engineering; saccharomyces cerevisiae; analysis results ... See more keywords
A comparative genomic and transcriptomic analysis at the level of isolated root hair cells reveals new conserved root hair regulatory elements
Sign Up to like & getrecommendations! Published in 2017 at "Plant Molecular Biology"
DOI: 10.1007/s11103-017-0630-8
Abstract: Key messageA comparative transcriptomic and genomic analysis between Arabidopsis thaliana and Glycine max root hair genes reveals the evolution of the expression of plant genes after speciation and whole genome duplication.AbstractOur understanding of the conservation… read more here.
Keywords: genomic transcriptomic; plant; analysis; hair ... See more keywords
Machine learning analysis using 77,044 genomic and transcriptomic profiles to accurately predict tumor type
Sign Up to like & getrecommendations! Published in 2021 at "Translational Oncology"
DOI: 10.1016/j.tranon.2021.101016
Abstract: Highlights • CUP occurs in as many as 3–5% of patients when standard diagnostic tests are not able to determine the origin of cancer.• MI GPSai (Genomic Prevalence Score) is an AI that uses genomic… read more here.
Keywords: genomic transcriptomic; learning analysis; machine learning; tumor type ... See more keywords
Genomic and transcriptomic changes complement each other in the pathogenesis of sporadic Burkitt lymphoma
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-08578-3
Abstract: Burkitt lymphoma (BL) is the most common B-cell lymphoma in children. Within the International Cancer Genome Consortium (ICGC), we performed whole genome and transcriptome sequencing of 39 sporadic BL. Here, we unravel interaction of structural, mutational,… read more here.
Keywords: genomic transcriptomic; lymphoma; pathogenesis; burkitt lymphoma ... See more keywords
Genomic and transcriptomic characterization of the Collimonas quorum sensing genes and regulon.
Sign Up to like & getrecommendations! Published in 2022 at "FEMS microbiology ecology"
DOI: 10.1093/femsec/fiac100
Abstract: Collimonads are well adapted to nutrient-poor environments. They are known to hydrolyse chitin, produce antifungal metabolites, weather minerals, and are effective biocontrol agents protecting plants from fungal diseases. The production of N-acyl homoserine lactones (AHLs)… read more here.
Keywords: collimonas quorum; ecology; characterization collimonas; quorum sensing ... See more keywords
An integrative overview of genomic, transcriptomic and proteomic analyses in organohalide respiration research
Sign Up to like & getrecommendations! Published in 2018 at "FEMS Microbiology Ecology"
DOI: 10.1093/femsec/fiy013
Abstract: ABSTRACT Organohalide respiration (OHR) is a crucial process in the global halogen cycle and of interest for bioremediation. However, investigations on OHR are hampered by the restricted genetic accessibility and the poor growth yields of… read more here.
Keywords: genomic transcriptomic; respiration; organohalide respiration; integrative overview ... See more keywords
Integrative analysis of genomic and transcriptomic alterations of AGR2 and AGR3 in cancer
Sign Up to like & getrecommendations! Published in 2022 at "Open Biology"
DOI: 10.1101/2022.03.08.483441
Abstract: The AGR2 and AGR3 genes have been shown by numerous groups to be functionally associated to adenocarcinoma progression and metastasis. We explore in this paper the data available in databases concerning genomic and transcriptomic features… read more here.
Keywords: expression; agr2 agr3; cell fitness; integrative analysis ... See more keywords
Integrated genomic and transcriptomic analysis reveals unique mechanisms for high osmotolerance and halotolerance in Hyphopichia yeast.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental microbiology"
DOI: 10.1111/1462-2920.15464
Abstract: The yeast species Hyphopichia is common in nature and strongly competitive under harsh environmental conditions. Here, we characterized Hyphopichia burtonii KJJ43 and H. pseudoburtonii KJS14, which exhibit strong halotolerance, using genomic and transcriptomic analyses. The… read more here.
Keywords: genomic transcriptomic; analysis reveals; halotolerance; analysis ... See more keywords
Abstract 3948: Comprehensive characterization of genomic and transcriptomic heterogeneity in advanced bladder cancer by multiregional analysis
Sign Up to like & getrecommendations! Published in 2017 at "Cancer Research"
DOI: 10.1158/1538-7445.am2017-3948
Abstract: Background: Bladder cancer is a highly heterogeneous disease - both clinically, and at the genomic and the transcriptomic levels. Despite complete tumor resections, recurrent tumors share a high number of mutations with the initial/earlier tumors,… read more here.
Keywords: genomic transcriptomic; bladder cancer; heterogeneity; disease ... See more keywords