Functional genomics analysis reveals the evolutionary adaptation and demographic history of pygmy lorises
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2123030119
Abstract: Significance Although strepsirrhines occupy a key node in primate phylogeny, our knowledge of this group remains quite limited. Here, we integrate comparative genomics analyses and functional assays to reveal the genetic underpinnings of evolutionary adaptation… read more here.
Keywords: pygmy; analysis reveals; adaptation; genomics analysis ... See more keywords
Integrative genomics analysis reveals a 21q22.11 locus contributing risk to COVID-19
Sign Up to like & getrecommendations! Published in 2021 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddab125
Abstract: Abstract The systematic identification of host genetic risk factors is essential for the understanding and treatment of coronavirus disease 2019 (COVID-19). By performing a meta-analysis of two independent genome-wide association summary datasets (N = 680 128), a novel… read more here.
Keywords: ifnar2 il10rb; genomics analysis; integrative genomics; covid ... See more keywords
Integrative genomics analysis highlights functionally relevant genes for equine behaviour.
Sign Up to like & getrecommendations! Published in 2023 at "Animal genetics"
DOI: 10.1111/age.13320
Abstract: Behavioural plasticity enables horses entering an exercise training programme to adapt with reduced stress. We characterised SNPs associated with behaviour in yearling Thoroughbred horses using genomics analyses for two phenotypes: (1) handler-assessed coping with early… read more here.
Keywords: genomics analysis; functionally relevant; relevant genes; analysis highlights ... See more keywords
Genus-Wide Comparative Genomics Analysis of Neisseria to Identify New Genes Associated with Pathogenicity and Niche Adaptation of Neisseria Pathogens
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DOI: 10.1155/2019/6015730
Abstract: N. gonorrhoeae and N. meningitidis, the only two human pathogens of Neisseria, are closely related species. But the niches they survived in and their pathogenic characteristics are distinctly different. However, the genetic basis of these… read more here.
Keywords: comparative genomics; genomics analysis; analysis; pathogenicity niche ... See more keywords
Visual Genomics Analysis Studio as a Tool to Analyze Multiomic Data
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2021.642012
Abstract: Type B adverse drug reactions (ADRs) are iatrogenic immune-mediated syndromes with mechanistic etiologies that remain incompletely understood. Some of the most severe ADRs, including delayed drug hypersensitivity reactions, are T-cell mediated, restricted by specific human… read more here.
Keywords: single cell; visual genomics; genomics analysis; analysis ... See more keywords
Computational Strategies for Scalable Genomics Analysis
Sign Up to like & getrecommendations! Published in 2019 at "Genes"
DOI: 10.3390/genes10121017
Abstract: The revolution in next-generation DNA sequencing technologies is leading to explosive data growth in genomics, posing a significant challenge to the computing infrastructure and software algorithms for genomics analysis. Various big data technologies have been… read more here.
Keywords: strategies scalable; computational strategies; scalable genomics; genomics analysis ... See more keywords