A broad comparative genomics approach to understanding the pathogenicity of Complex I mutations
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-98360-7
Abstract: Disease caused by mutations of mitochondrial DNA (mtDNA) are highly variable in both presentation and penetrance. Over the last 30 years, clinical recognition of this group of diseases has increased. It has been suggested that… read more here.
Keywords: comparative genomics; genomics approach; broad comparative; approach understanding ... See more keywords
Functional Genomics Approach Identifies Novel Signaling Regulators of TGFα Ectodomain Shedding
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DOI: 10.1158/1541-7786.mcr-17-0140
Abstract: Ectodomain shedding of cell-surface precursor proteins by metalloproteases generates important cellular signaling molecules. Of importance for disease is the release of ligands that activate the EGFR, such as TGFα, which is mostly carried out by… read more here.
Keywords: genomics approach; functional genomics; ectodomain shedding; egfr ligand ... See more keywords
Proteogenomic analysis of Serratia marcescens using computational subtractive genomics approach
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DOI: 10.1371/journal.pone.0283993
Abstract: Serratia marcescens, a Gram-negative bacterium (Enterobacteriaceae) is a hospital-acquired opportunistic pathogen that infects the urinary and central nervous systems. The identification of new therapeutics against S. marcescens is crucial since it is now multi-drug resistant.… read more here.
Keywords: serratia marcescens; subtractive genomics; genomics approach; analysis ... See more keywords