Spatial CRISPR genomics identifies regulators of the tumor microenvironment
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DOI: 10.1016/j.cell.2022.02.015
Abstract: While CRISPR screens are helping uncover genes regulating many cell-intrinsic processes, existing approaches are suboptimal for identifying extracellular gene functions, particularly in the tissue context. Here, we developed an approach for spatial functional genomics called… read more here.
Keywords: crispr genomics; genomics identifies; tumor microenvironment; perturb map ... See more keywords
Comparative genomics identifies distinct lineages of S. Enteritidis from Queensland, Australia
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DOI: 10.1371/journal.pone.0191042
Abstract: Salmonella enterica is a major cause of gastroenteritis and foodborne illness in Australia where notification rates in the state of Queensland are the highest in the country. S. Enteritidis is among the five most common… read more here.
Keywords: comparative genomics; distinct lineages; genomics identifies; identifies distinct ... See more keywords
Comparative functional genomics identifies unique molecular features of EPSCs
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DOI: 10.26508/lsa.202201608
Abstract: The authors provide a comprehensive resource on proteomics, transcriptomic, and epigenetic level details of EPSCs to shed light on possible molecular pathways regulating their expanded pluripotency potential. Extended pluripotent or expanded potential stem cells (EPSCs)… read more here.
Keywords: comparative functional; identifies unique; genomics identifies; functional genomics ... See more keywords