In vitro responses to known in vivo genotoxic agents in mouse germ cells
Sign Up to like & getrecommendations! Published in 2017 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22075
Abstract: Genotoxic compounds have induced DNA damage in male germ cells and have been associated with adverse clinical outcomes including enhanced risks for maternal, paternal and offspring health. DNA strand breaks represent a great threat to… read more here.
Keywords: germ cells; dna damage; genotoxic; mms ... See more keywords
Naturally occurring mixtures of Alternaria toxins: anti-estrogenic and genotoxic effects in vitro.
Sign Up to like & getrecommendations! Published in 2019 at "Archives of toxicology"
DOI: 10.1007/s00204-019-02545-z
Abstract: Alternaria molds can produce a variety of different mycotoxins, often resulting in food contamination with chemical mixtures, posing a challenge for risk assessment. Some of these metabolites possess estrogenic properties, an effect whose toxicological relevance… read more here.
Keywords: occurring mixtures; mixtures alternaria; anti estrogenic; estrogenic effects ... See more keywords
Mode of action-based risk assessment of genotoxic carcinogens
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Toxicology"
DOI: 10.1007/s00204-020-02733-2
Abstract: The risk assessment of chemical carcinogens is one major task in toxicology. Even though exposure has been mitigated effectively during the last decades, low levels of carcinogenic substances in food and at the workplace are… read more here.
Keywords: risk; risk assessment; genotoxic carcinogens; genotoxic ... See more keywords
Mutagenic and genotoxic effects of Anilofos with micronucleus, chromosome aberrations, sister chromatid exchanges and Ames test
Sign Up to like & getrecommendations! Published in 2017 at "Cytotechnology"
DOI: 10.1007/s10616-017-0099-y
Abstract: We aimed to evaluate the mutagenic effect of Anilofos, organophosphate pesticide, by using Ames/Salmonella/microsome test. Its cytotoxic and genotoxic effects were also determined by chromosome aberration (CA), sister chromatid exchange (SCE) and micronucleus (MN) test… read more here.
Keywords: sister chromatid; genotoxic effects; 100 200; genotoxic ... See more keywords
Assessment of in vitro cytotoxic and genotoxic activities of some trimethoprim conjugates
Sign Up to like & getrecommendations! Published in 2018 at "Cytotechnology"
DOI: 10.1007/s10616-018-0187-7
Abstract: Trimethoprim, a commonly used antibacterial agent, is widely applied in the treatment of variety of infections in human. A few studies have demonstrated an extensive exposure of man to antibiotics, but there is still a… read more here.
Keywords: cytotoxic; activities trimethoprim; genotoxic activities; assessment vitro ... See more keywords
Genotoxic activity of l-asparaginase produced by Streptomyces ansochromogenes UFPEDA 3420
Sign Up to like & getrecommendations! Published in 2019 at "World Journal of Microbiology and Biotechnology"
DOI: 10.1007/s11274-019-2612-2
Abstract: Abstractl-asparaginase is an enzyme capable of hydrolyzing the substrate asparagine in aspartic acid and ammonia. Due to this mechanism of action observed, l-asparaginase is widely used in the treatment of Acute Lymphoblastic Leukemia, since these… read more here.
Keywords: ansochromogenes ufpeda; produced streptomyces; asparaginase produced; ufpeda 3420 ... See more keywords
Evaluation of the Genotoxic and Antigenotoxic Potential of Lignin-derivative BP-C2 in the Comet Assay In Vivo.
Sign Up to like & getrecommendations! Published in 2020 at "Environmental research"
DOI: 10.1016/j.envres.2020.110321
Abstract: The genotoxic and antigenotoxic potential of BP-C2, a novel lignin-derived polyphenolic composition with ammonium molybdate, was investigated as a radioprotector/radiomitigator for civic applications and as a medical countermeasure for radiation emergencies. Using the alkaline comet… read more here.
Keywords: comet assay; genotoxic antigenotoxic; antigenotoxic potential; lignin ... See more keywords
The potential of geraniol to reduce cytotoxic and genotoxic effects of MNNG in plant and human lymphocyte test-systems
Sign Up to like & getrecommendations! Published in 2019 at "South African Journal of Botany"
DOI: 10.1016/j.sajb.2019.03.005
Abstract: Abstract Geraniol is a common component of essential oils of various plant species and is widely used in cosmetics, perfumery and household products. In the present study, we investigated the cytotoxic, genotoxic and antioxidant activities… read more here.
Keywords: test systems; cytotoxic genotoxic; genotoxic effects; genotoxic ... See more keywords
Evaluation of cytotoxicity, genotoxicity, and apoptosis of wastewater before and after disinfection with performic acid.
Sign Up to like & getrecommendations! Published in 2017 at "Water research"
DOI: 10.1016/j.watres.2017.03.016
Abstract: Disinfection with performic acid (PFA) represents an emerging technology in wastewater treatment. Many recent studies indicate its effectiveness and suitability as a disinfectant for different applications; several have demonstrated its reliability as an alternative to… read more here.
Keywords: performic acid; disinfection performic; disinfection; treatment ... See more keywords
Parallelogram based approach for in vivo dose estimation of genotoxic metabolites in humans with relevance to reduction of animal experiments
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-17692-5
Abstract: When employing metabolism studies of genotoxic compounds/metabolites and cancer tests for risk estimation, low exposure doses in humans are roughly extrapolated from high exposure doses in animals. An improvement is to measure the in vivo… read more here.
Keywords: estimation; parallelogram based; approach; based approach ... See more keywords
Stem cell proliferation patterns as an alternative for in vivo prediction and discrimination of carcinogenic compounds
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep45616
Abstract: One of the major challenges in the development of alternative carcinogenicity assays is the prediction of non-genotoxic carcinogens. The variety of non-genotoxic cancer pathways complicates the search for reliable parameters expressing their carcinogenicity. As non-genotoxic… read more here.
Keywords: non genotoxic; proliferation; stem cell; genotoxic ... See more keywords