Assessment of in vitro cytotoxic and genotoxic activities of some trimethoprim conjugates
Sign Up to like & getrecommendations! Published in 2018 at "Cytotechnology"
DOI: 10.1007/s10616-018-0187-7
Abstract: Trimethoprim, a commonly used antibacterial agent, is widely applied in the treatment of variety of infections in human. A few studies have demonstrated an extensive exposure of man to antibiotics, but there is still a… read more here.
Keywords: cytotoxic; activities trimethoprim; genotoxic activities; assessment vitro ... See more keywords
Novel nitroimidazole derivatives evaluated for their trypanocidal, cytotoxic, and genotoxic activities.
Sign Up to like & getrecommendations! Published in 2019 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2019.111887
Abstract: The current treatment of Chagas disease is based on the use of two drugs, nifurtimox (Nfx) and benznidazole (Bnz), both of which present limited efficacy in the chronic stage of the disease and toxic side… read more here.
Keywords: nitroimidazole derivatives; genotoxic activities; derivatives evaluated; novel nitroimidazole ... See more keywords