Evaluation of a 4-day repeated-dose micronucleus test in rat glandular stomach and colon using aneugens and non-genotoxic non-carcinogens
Sign Up to like & getrecommendations! Published in 2022 at "Genes and Environment"
DOI: 10.1186/s41021-022-00241-6
Abstract: Background We previously developed a rodent gastrointestinal (GI) tract micronucleus (MN) test using the glandular stomach and/or colon, and evaluated this test method using several genotoxic carcinogens (clastogens) and genotoxic non-carcinogens; we demonstrated that this… read more here.
Keywords: stomach colon; glandular stomach; genotoxic non; stomach ... See more keywords
Differential responses on energy metabolic pathway reprogramming between genotoxic and non-genotoxic hepatocarcinogens in rat liver cells
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DOI: 10.1293/tox.2019-0048
Abstract: To clarify difference in the responses on the reprogramming of metabolism toward carcinogenesis between genotoxic and non-genotoxic hepatocarcinogens in the liver, rats were repeatedly administered genotoxic hepatocarcinogens (N-nitrosodiethylamine, aflatoxin B1, N-nitrosopyrrolidine, or carbadox) or non-genotoxic… read more here.
Keywords: genotoxic hepatocarcinogens; days suggesting; non genotoxic; genotoxic non ... See more keywords