Comparing BMD‐derived genotoxic potency estimations across variants of the transgenic rodent gene mutation assay
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DOI: 10.1002/em.22137
Abstract: There is growing interest in quantitative analysis of in vivo genetic toxicity dose‐response data, and use of point‐of‐departure (PoD) metrics such as the benchmark dose (BMD) for human health risk assessment (HHRA). Currently, multiple transgenic… read more here.
Keywords: dose response; potency; bmd; transgenic rodent ... See more keywords
The in vitro genotoxicity potency of mixtures of pyrrolizidine alkaloids can be explained by dose addition of the individual mixture components
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DOI: 10.1002/em.22512
Abstract: Plant‐based 1,2‐unsaturated Pyrrolizidine Alkaloids (PAs) are responsible for liver genotoxicity/carcinogenicity following metabolic activation, making them a relevant concern for safety assessment. Due to 21st century toxicology approaches, risk of PAs can be better discerned though… read more here.
Keywords: potency; vitro genotoxicity; genotoxic potency; genotoxicity potency ... See more keywords
Investigation and Comparison of In Vitro Genotoxic Potency of PM10 Collected in Rural and Urban Sites at Tehran in Different Metrological Conditions and Different Seasons
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DOI: 10.1007/s12011-018-1469-9
Abstract: The particulate matter has become a serious health problem in some large cities in the world. These particles are a complex mixture of chemical compounds which change based on location and time and, consequently, can… read more here.
Keywords: potency pm10; investigation comparison; comparison vitro; pm10 collected ... See more keywords