Sister Chromatid Exchange as a Genotoxic Stress Marker.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9432-8_7
Abstract: Sister chromatid exchange (SCE) is the phenomenon of partial DNA exchange during DNA replication. SCE detection has been developed through eliciting DNA's semiconservative replicative nature. Thymidine analogues such as 5'-bromodeoxyuridine (BrdU) and ethynyldeoxyuridine (EdU) are incorporated into… read more here.
Keywords: sister chromatid; dna; chromatid exchange; exchange ... See more keywords
Investigating the underlying mechanism of cadmium-induced plant adaptive response to genotoxic stress.
Sign Up to like & getrecommendations! Published in 2020 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2020.111817
Abstract: Plants as sessile organisms have developed some unique strategies to withstand environmental stress and adaptive response (AR) is one of them. In the present study Cadmium (Cd)-induced AR was evaluated to ameliorate the genotoxicity of… read more here.
Keywords: stress; cadmium induced; adaptive response; genotoxic stress ... See more keywords
cGAS Micro-Manages Genotoxic Stress.
Sign Up to like & getrecommendations! Published in 2017 at "Immunity"
DOI: 10.1016/j.immuni.2017.09.020
Abstract: Maintenance of genome integrity is essential to prevent cancer. Genotoxic stress drives damaged DNA out of the nucleus by forming micronuclei. Two studies in Nature reveal how the cytosolic DNA sensor cGAS gains access to… read more here.
Keywords: manages genotoxic; micro manages; cgas micro; stress ... See more keywords
Reactive oxygen species-evoked genotoxic stress mediates arsenic-induced suppression of male germ cell proliferation and decline in sperm quality.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of hazardous materials"
DOI: 10.1016/j.jhazmat.2020.124768
Abstract: This study aimed to investigate whether genotoxic stress mediates arsenic (As)-induced decline in sperm quality. Mice drank ultrapure water containing NaAsO2 (15 mg/L) for 70 days. The mature seminiferous tubules and epididymal sperm count were reduced… read more here.
Keywords: stress; cell proliferation; genotoxic stress; stress mediates ... See more keywords
Induction of APOBEC3C facilitates the genotoxic stress-mediated cytotoxicity of artesunate.
Sign Up to like & getrecommendations! Published in 2019 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.9b00358
Abstract: Artemisinin class of anticancer compounds is well-known for oxidative DNA damage-mediated growth arrest followed by cell death. However, the nature of this genotoxic stress for cancer therapeutics remains elusive. Here, we show that artesunate (Art),… read more here.
Keywords: dna damage; a3c; apobec3c; art ... See more keywords
Genotoxic stress-activated DNA-PK-p53 cascade and autophagy cooperatively induce ciliogenesis to maintain the DNA damage response
Sign Up to like & getrecommendations! Published in 2021 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-020-00713-8
Abstract: The DNA-PK maintains cell survival when DNA damage occurs. In addition, aberrant activation of the DNA-PK induces centrosome amplification, suggesting additional roles for this kinase. Here, we showed that the DNA-PK-p53 cascade induced primary cilia… read more here.
Keywords: dna damage; ciliogenesis; genotoxic stress; dna ... See more keywords
Convergent evolution of a genotoxic stress response in a parasite-specific p53 homolog
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2205201119
Abstract: Significance P53 is an important tumor suppressor that is found throughout metazoans, including invertebrates that do not develop malignancies. The prevailing theory for why these invertebrates possess a tumor suppressor is that P53 originally evolved… read more here.
Keywords: convergent evolution; parasite specific; p53; genotoxic stress ... See more keywords
Genotoxic stress of particulate matter in the electric furnace of an iron casting industry on human lung epithelial cells; an in vitro study
Sign Up to like & getrecommendations! Published in 2020 at "Toxin Reviews"
DOI: 10.1080/15569543.2020.1783318
Abstract: In foundries, various ores are used. Genotoxic assessment of ore-particles was the important aim of this study. In this regard, Ferrochromium, Ferrosilicon, Ferromanganese, and graphite were collec... read more here.
Keywords: stress particulate; study; electric furnace; matter electric ... See more keywords
Intracellular mechanism by which genotoxic stress activates yeast SAPK Mpk1
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e18-07-0441
Abstract: Stress-activated MAP kinases (SAPKs) respond to a wide variety of stressors. In most cases, the pathways through which specific stress signals are transmitted to the SAPKs are not known. The Saccharomyces cerevisiae SAPK Mpk1 (Slt2)… read more here.
Keywords: mpk1; stress; cell wall; genotoxic stress ... See more keywords
ATM-mediated ELL phosphorylation enhances its self-association through increased EAF1 interaction and inhibits global transcription during genotoxic stress
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac943
Abstract: Abstract Mammalian cells immediately inhibit transcription upon exposure to genotoxic stress to avoid fatal collision between ongoing transcription and newly recruited DNA repair machineries to protect genomic integrity. However, mechanisms of this early transcriptional inhibition… read more here.
Keywords: transcription; interaction; association; genotoxic stress ... See more keywords
Tracing brain genotoxic stress in Parkinson’s disease with a novel single-cell genetic sensor
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abd1700
Abstract: To develop an in vivo tool to probe brain genotoxic stress, we designed a viral proxy as a single-cell genetic sensor termed PRISM that harnesses the instability of recombinant adeno-associated virus genome processing and a… read more here.
Keywords: stress; genotoxic stress; brain genotoxic; cell ... See more keywords