A commensal-encoded genotoxin drives restriction of Vibrio cholerae colonization and host gut microbiome remodeling
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2121180119
Abstract: Significance In a polymicrobial battlefield where different species compete for nutrients and colonization niches, antimicrobial compounds are the sword and shield of commensal microbes in competition with invading pathogens and each other. The identification of… read more here.
Keywords: commensal encoded; genotoxin; vibrio cholerae; colonization ... See more keywords
Infection with genotoxin‐producing Salmonella enterica synergises with loss of the tumour suppressor APC in promoting genomic instability via the PI3K pathway in colonic epithelial cells
Sign Up to like & getrecommendations! Published in 2019 at "Cellular Microbiology"
DOI: 10.1111/cmi.13099
Abstract: Several commensal and pathogenic Gram‐negative bacteria produce DNA‐damaging toxins that are considered bona fide carcinogenic agents. The microbiota of colorectal cancer (CRC) patients is enriched in genotoxin‐producing bacteria, but their role in the pathogenesis of… read more here.
Keywords: epithelial cells; colonic epithelial; genotoxin producing; infection ... See more keywords
A Toxic Friend: Genotoxic and Mutagenic Activity of the Probiotic Strain Escherichia coli Nissle 1917
Sign Up to like & getrecommendations! Published in 2021 at "mSphere"
DOI: 10.1128/msphere.00624-21
Abstract: Nissle 1917 is sold as a probiotic and considered safe even though it has been known since 2006 that it harbors the genes for colibactin synthesis. Colibactin is a potent genotoxin that is now linked… read more here.
Keywords: genotoxin; nissle 1917; colibactin; escherichia coli ... See more keywords
Genotoxins: The Mechanistic Links between Escherichia coli and Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2023 at "Cancers"
DOI: 10.3390/cancers15041152
Abstract: Simple Summary Colorectal cancer (CRC) is a leading cause of cancer-related mortality worldwide, and its incidence is steadily rising in developing areas. Bacterial pathogens from the gut microbiota have been recognized as important risk factors… read more here.
Keywords: genotoxin; host cells; escherichia coli; colorectal cancer ... See more keywords