Evaluation of the Association of Perioperative UGT1A1 Genotype-Dosed gFOLFIRINOX With Margin-Negative Resection Rates and Pathologic Response Grades Among Patients With Locally Advanced Gastroesophageal Adenocarcinoma: A Phase 2 Clinical Trial.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA network open"
DOI: 10.1001/jamanetworkopen.2019.21290
Abstract: Importance Patients with locally advanced gastroesophageal adenocarcinoma (ie, stage ≥T3 and/or node positive) have high rates of recurrence despite surgery and adjunctive perioperative therapies, which also have high toxicity profiles. Evaluation of pharmacogenomically dosed perioperative… read more here.
Keywords: ugt1a1 genotype; genotype; gastroesophageal; patients locally ... See more keywords
Herbivory in a changing climate—Effects of plant genotype and experimentally induced variation in plant phenology on two summer‐active lepidopteran herbivores and one fungal pathogen
Sign Up to like & getrecommendations! Published in 2022 at "Ecology and Evolution"
DOI: 10.1002/ece3.8495
Abstract: Abstract With climate change, spring warming tends to advance plant leaf‐out. While the timing of leaf‐out has been shown to affect the quality of leaves for herbivores in spring, it is unclear whether such effects… read more here.
Keywords: two summer; plant phenology; phenology; genotype ... See more keywords
Combination of late gadolinium enhancement and genotype improves prediction of prognosis in non‐ischaemic dilated cardiomyopathy
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Heart Failure"
DOI: 10.1002/ejhf.2514
Abstract: Genotype and left ventricular scar on cardiac magnetic resonance (CMR) are increasingly recognized as risk markers for adverse outcomes in non‐ischaemic dilated cardiomyopathy (DCM). We investigated the combined influence of genotype and late gadolinium enhancement… read more here.
Keywords: ischaemic dilated; non ischaemic; late gadolinium; genotype ... See more keywords
PhredEM: a phred‐score‐informed genotype‐calling approach for next‐generation sequencing studies
Sign Up to like & getrecommendations! Published in 2017 at "Genetic Epidemiology"
DOI: 10.1002/gepi.22048
Abstract: A fundamental challenge in analyzing next‐generation sequencing (NGS) data is to determine an individual's genotype accurately, as the accuracy of the inferred genotype is essential to downstream analyses. Correctly estimating the base‐calling error rate is… read more here.
Keywords: genotype; genotype calling; next generation; phredem ... See more keywords
Intermediate confounding in trio relationships: The importance of complete data in effect size estimation
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DOI: 10.1002/gepi.22294
Abstract: We present an important characteristic of trio models which may lead to bias and loss of power when one parent is unmodeled in trio analyses. Motivated by recent interest in estimating parental effects on postnatal… read more here.
Keywords: estimation; intermediate confounding; genotype; effect ... See more keywords
Trajectories of depression symptoms over time differ by APOE4 genotype in older adults with type 2 diabetes
Sign Up to like & getrecommendations! Published in 2021 at "International Journal of Geriatric Psychiatry"
DOI: 10.1002/gps.5583
Abstract: The APOE‐ε4 genotype has been associated with old‐age depression, but this relationship has been rarely investigated in type 2 diabetes (T2D) older adults, who are at significantly increased risk for depression, a major contributor to… read more here.
Keywords: depression; depression symptoms; genotype; type diabetes ... See more keywords
Hepatitis B Virus (HBV) Genotype: A Significant Risk Factor in Determining which Patients with Chronic HBV Infection should Undergo Surveillance for Hepatocellular Carcinoma: The Hepatitis B Alaska (HEP-B-AK) Study.
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.32065
Abstract: BACKGROUND AND AIMS Information is limited regarding hepatitis B virus (HBV) genotype and the outcome of chronic HBV (CHB) infection. We examined HBV genotype on hepatocellular carcinoma (HCC) occurrence in Alaska Native (AN) persons with… read more here.
Keywords: risk; hcc; hepatitis; genotype ... See more keywords
Tissue‐specific genotype–phenotype correlations among USH2A‐related disorders in the RUSH2A study
Sign Up to like & getrecommendations! Published in 2022 at "Human Mutation"
DOI: 10.1002/humu.24365
Abstract: We assessed genotype–phenotype correlations among the visual, auditory, and olfactory phenotypes of 127 participants with Usher syndrome (USH2) (n =80) or nonsyndromic autosomal recessive retinitis pigmentosa (ARRP) (n = 47) due to USH2A variants, using clinical data and… read more here.
Keywords: ush2a related; phenotype correlations; genotype; genotype phenotype ... See more keywords
Toremifene, rather than tamoxifen, might be a better option for the adjuvant endocrine therapy in CYP2D6*10T/T genotype breast cancer patients in China
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DOI: 10.1002/ijc.31639
Abstract: Toremifene (TOR) is a valid and safe alternative to tamoxifen (TAM) for adjuvant endocrine therapy in breast cancer patients with a metabolic pathway that differs from that of TAM. TOR might have a therapeutic advantage… read more here.
Keywords: genotype; breast cancer; tor; cancer ... See more keywords
VP7 and VP8* genetic characterization of group A rotavirus genotype G12P[8]: Emergence and spreading in the Eastern Brazilian coast in 2014
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DOI: 10.1002/jmv.24605
Abstract: Group A rotavirus (RVA) genotype G12 is habitually associated with diarrhea disease (DD) in African children and recently its detection has increased worldwide. A total of 970 stool samples collected from individuals with DD in… read more here.
Keywords: vp7 vp8; group rotavirus; genotype; g12p ... See more keywords
High spontaneous clearance of symptomatic iatrogenic acute hepatitis C genotype 4 infection
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Medical Virology"
DOI: 10.1002/jmv.25270
Abstract: Acute hepatitis C (AHC) infection resolves spontaneously in 15% to 40% of patients. Factors favoring spontaneous viral clearance remain undefined. In this study, predictors of spontaneous viral clearance in patients with symptomatic AHC were investigated.… read more here.
Keywords: hepatitis; acute hepatitis; infection; genotype ... See more keywords