Constrained maximum entropy models to select genotype interactions associated with censored failure times
Sign Up to like & getrecommendations! Published in 2018 at "Journal of bioinformatics and computational biology"
DOI: 10.1142/s0219720018400243
Abstract: We propose a novel screening method targeting genotype interactions associated with disease risks. The proposed method extends the maximum entropy conditional probability model to address disease occurrences over time. Continuous occurrence times are grouped into… read more here.
Keywords: maximum entropy; genotype interactions; disease; occurrence ... See more keywords
Human and pathogen genotype-by-genotype interactions in the light of coevolution theory
Sign Up to like & getrecommendations! Published in 2023 at "PLOS Genetics"
DOI: 10.1371/journal.pgen.1010685
Abstract: Antagonistic coevolution (i.e., reciprocal adaptation and counter-adaptation) between hosts and pathogens has long been considered an important driver of genetic variation. However, direct evidence for this is still scarce, especially in vertebrates. The wealth of… read more here.
Keywords: theory; genotype; coevolution; genotype interactions ... See more keywords