Genotyping and phenotyping CYP3A4\CYP3A5: no association with antiplatelet effect of clopidogrel
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DOI: 10.1007/s11033-019-04871-y
Abstract: The objective of this study was to determine the impact of polymorphism of CYP3A subfamily isoenzymes (allelic variants of CYP3A4*22 and CYP3A5*3) on the efficacy clopidogrel in patients with an acute coronary syndrome (ACS), who… read more here.
Keywords: clopidogrel; cyp3a4 cyp3a5; phenotyping cyp3a4; antiplatelet effect ... See more keywords
A Genotyping/Phenotyping Approach with Careful Clinical Monitoring to Manage the Fluoropyrimidines-Based Therapy: Clinical Cases and Systematic Review of the Literature
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DOI: 10.3390/jpm10030113
Abstract: Fluoropyrimidines (FP) are mainly metabolised by dihydropyrimidine dehydrogenase (DPD), encoded by the DPYD gene. FP pharmacogenetics, including four DPYD polymorphisms (DPYD-PGx), is recommended to tailor the FP-based chemotherapy. These polymorphisms increase the risk of severe… read more here.
Keywords: systematic review; clinical monitoring; genotyping phenotyping; dpyd pgx ... See more keywords