Gentamycin Rationally Repositioned to Inhibit miR-34a Ameliorates Oxidative Injury to PC12 Cells
Sign Up to like & getrecommendations! Published in 2022 at "ACS Omega"
DOI: 10.1021/acsomega.2c06112
Abstract: Ischemic stroke accompanies oxidative stress and cell death in the cerebral tissue. The microRNA miR-34a plays a pivotal role in this molecular pathology. This study presents the rational repositioning of aminoglycosidic antibiotics as miR-34a antagonists… read more here.
Keywords: gentamycin; mir 34a; pc12 cells; oxidative injury ... See more keywords
Ezetimibe protects against Gentamycin-induced ototoxicity in rats by antioxidants, anti-inflammatory mechanisms, and BDNF upregulation
Sign Up to like & getrecommendations! Published in 2024 at "Immunopharmacology and Immunotoxicology"
DOI: 10.1080/08923973.2024.2390463
Abstract: Abstract Objective The threat of hearing loss has become a universal reality. Gentamycin (GM) can lead to ototoxicity and may result in permanent hearing loss. This study aimed to elucidate whether the hypolipidemic drug Ezetimibe… read more here.
Keywords: immunoreaction; ototoxicity; gentamycin; ezetimibe ... See more keywords