Geographic Atrophy and Foveal-Sparing Changes Related to Visual Acuity in Patients With Dry Age-Related Macular Degeneration Over Time.
Sign Up to like & getrecommendations! Published in 2017 at "American journal of ophthalmology"
DOI: 10.1016/j.ajo.2017.03.031
Abstract: PURPOSE To correlate the area of geographic atrophy (GA) and residual foveal sparing (FS), and to identify the minimum FS and maximum GA area allowing sufficient visual acuity (VA) for daily tasks. DESIGN Prospective cohort… read more here.
Keywords: mm2; area; foveal sparing; visual acuity ... See more keywords
Role of deep learning quantified hyperreflective foci for the prediction of geographic atrophy progression.
Sign Up to like & getrecommendations! Published in 2020 at "American journal of ophthalmology"
DOI: 10.1016/j.ajo.2020.03.042
Abstract: PURPOSE To quantitatively measure hyperreflective foci (HRF) during the progression of geographic atrophy (GA) secondary to age-related macular degeneration (AMD) using deep learning (DL) and investigate the association with local and global growth of GA.… read more here.
Keywords: deep learning; hrf; hyperreflective foci; geographic atrophy ... See more keywords
Phase I Study of the Anti-HtrA1 Antibody-Binding Fragment FHTR2163 in Geographic Atrophy Secondary to Age-Related Macular Degeneration.
Sign Up to like & getrecommendations! Published in 2021 at "American journal of ophthalmology"
DOI: 10.1016/j.ajo.2021.06.017
Abstract: PURPOSE FHTR2163 is a novel antigen-binding fragment (Fab) directed against high-temperature requirement protein A1 (HtrA1). HtrA1 inhibition may preserve retinal integrity and slow disease progression in geographic atrophy (GA) secondary to age-related macular degeneration (AMD).… read more here.
Keywords: secondary age; age; atrophy secondary; study ... See more keywords
Geographic atrophy segmentation in SD-OCT images using synthesized fundus autofluorescence imaging
Sign Up to like & getrecommendations! Published in 2019 at "Computer methods and programs in biomedicine"
DOI: 10.1016/j.cmpb.2019.105101
Abstract: BACKGROUND AND OBJECTIVE Accurate assessment of geographic atrophy (GA) is critical for diagnosis and therapy of non-exudative age-related macular degeneration (AMD). Herein, we propose a novel GA segmentation framework for spectral-domain optical coherence tomography (SD-OCT)… read more here.
Keywords: oct images; network; segmentation; oct ... See more keywords
Progression of Geographic Atrophy in Age-related Macular Degeneration: AREDS2 Report Number 16.
Sign Up to like & getrecommendations! Published in 2018 at "Ophthalmology"
DOI: 10.1016/j.ophtha.2018.05.028
Abstract: PURPOSE To analyze the prevalence, incidence, and clinical characteristics of eyes with geographic atrophy (GA) in age-related macular degeneration (AMD), including clinical and genetic factors affecting enlargement. DESIGN Prospective cohort study within a controlled clinical… read more here.
Keywords: risk; age related; enlargement; geographic atrophy ... See more keywords
The association of geographic atrophy and decreased renal function in patients with age-related macular degeneration
Sign Up to like & getrecommendations! Published in 2017 at "Eye"
DOI: 10.1038/eye.2016.261
Abstract: PurposeThe purpose of the study was to investigate the association between area and presence of geographic atrophy (GA) and renal function, as measured by glomerular filtration rate (GFR).Patients and methodsWe retrospectively identified patients aged 50–90… read more here.
Keywords: age related; age; association; geographic atrophy ... See more keywords
Complement Inhibition for Geographic Atrophy: Review of Salient Functional Outcomes and Perspective.
Sign Up to like & getrecommendations! Published in 2023 at "Retina"
DOI: 10.1097/iae.0000000000003796
Abstract: PURPOSE To evaluate available rationale and outcomes of randomized trial results for complement inhibition for geographic atrophy. METHODS Data from recently completed randomized trials of complement inhibition, particularly for pegcetacoplan and avacincaptad pegol, were evaluated… read more here.
Keywords: complement inhibition; geographic atrophy; autofluorescence; atrophy ... See more keywords
Geographic atrophy: where we are now and where we are going
Sign Up to like & getrecommendations! Published in 2021 at "Current Opinion in Ophthalmology"
DOI: 10.1097/icu.0000000000000763
Abstract: Purpose of review Age-related macular degeneration (AMD) affects a significant percentage of the elderly population and end-stage disease classified by either geographic atrophy (GA) or neovascular AMD (nvAMD) is one of the leading causes of… read more here.
Keywords: atrophy going; atrophy; pathogenesis; mechanism ... See more keywords
Geographic Atrophy in AMD: Prognostic Factors Based on Long-Term Follow-Up.
Sign Up to like & getrecommendations! Published in 2022 at "Ophthalmic research"
DOI: 10.1111/j.1755-3768.2022.0106
Abstract: INTRODUCTION The aim of this large-scale long-term retrospective study was to show the enlargement rate (ER) of geographic atrophy (GA) in age-related macular degeneration (AMD), defined as complete retinal pigment epithelium and outer retinal atrophy… read more here.
Keywords: long term; year; baseline; area ... See more keywords
Automated choroidal segmentation in spectral optical coherence tomography images with geographic atrophy using multimodal complementary information
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Medical Imaging"
DOI: 10.1117/1.jmi.6.2.024009
Abstract: Abstract. Changes in the choroid have been suggested to be of critical relevance to some eye diseases, e.g., geographic atrophy (GA) of age-related macular degeneration (AMD). Several groups have worked to develop automated choroidal segmentation… read more here.
Keywords: optical coherence; automated choroidal; choroidal segmentation; segmentation ... See more keywords
Core outcomes for geographic atrophy trials
Sign Up to like & getrecommendations! Published in 2019 at "British Journal of Ophthalmology"
DOI: 10.1136/bjophthalmol-2019-314949
Abstract: Background/Aims Ongoing and recent clinical trials for geographic atrophy (GA) have used different outcomes. The goal of this study was to identify a core outcome set (COS) important for patients, clinicians and researchers, and to… read more here.
Keywords: geographic atrophy; atrophy trials; outcomes geographic; core outcomes ... See more keywords