Clinical outcomes of gastroenteropancreatic neuroendocrine neoplasms in Taiwan: A multicenter registry study—TCOG T1214 study
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DOI: 10.1002/cncr.70019
Abstract: Gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) account for more than 50% of all NENs. The survival of patients with GEP‐NENs has improved based on early diagnosis and improved treatment strategies. The real‐world data of GEP‐NENs in Taiwan… read more here.
Keywords: registry study; gep nens; gastroenteropancreatic neuroendocrine; neuroendocrine neoplasms ... See more keywords
Radical intended surgery for highly selected stage IV neuroendocrine neoplasms G3.
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DOI: 10.1016/j.amjsurg.2020.03.009
Abstract: BACKGROUND Stage IV gastro-entero-pancreatic neuroendocrine neoplasms (GEP-NENs) G3 are the NENs with the worst prognosis. According to ENETS guidelines, platinum-based chemotherapy is the standard treatment for this population. Surgery is only considered in highly selected… read more here.
Keywords: intended surgery; gep nens; surgery; neuroendocrine neoplasms ... See more keywords
Development and validation of predictive models for distant metastasis and prognosis of gastroenteropancreatic neuroendocrine neoplasms
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DOI: 10.1038/s41598-025-92974-x
Abstract: Imaging examinations exhibit a certain rate of missed detection for distant metastases of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs). This study aims to develop and validate a risk prediction model for the distant metastases and prognosis of… read more here.
Keywords: distant metastasis; risk; prognosis; gep nens ... See more keywords
Efficacy and Toxicity of 5-Fluorouracil–Oxaliplatin in Gastroenteropancreatic Neuroendocrine Neoplasms
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DOI: 10.1097/mpa.0000000000001593
Abstract: Supplemental digital content is available in the text. Objectives The objective of this study was to investigate the efficacy and tolerability of 5-fluorouracil–oxaliplatin (FOLFOX) in advanced gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs). Methods Retrospective analysis of consecutive… read more here.
Keywords: fluorouracil oxaliplatin; gep nens; gastroenteropancreatic neuroendocrine; neuroendocrine neoplasms ... See more keywords
Role of immunotherapy in gastro‐enteropancreatic neuroendocrine neoplasms (gep‐nens): Current advances and future directions
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DOI: 10.1111/jne.12943
Abstract: Neuroendocrine neoplasms (NENs) are heterogeneous tumours originating from neuroendocrine cells (Pearse & Polak, Gut, 1971, 12,783). They were once considered as rare tumours, although their annual incidence has increased significantly and now exceeds seven cases… read more here.
Keywords: gep nens; gastro enteropancreatic; neuroendocrine neoplasms; oncology ... See more keywords
Incidence of gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs): An updated systematic review of population‐based reports from 2010 to 2023
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DOI: 10.1111/jne.70001
Abstract: There is a general perception that the incidence of neuroendocrine neoplasms (NENs) has been increasing. Nevertheless, reports of actual population‐based studies are scarce, and pertinent data from some geographical regions still need to be available.… read more here.
Keywords: review population; gep nens; neuroendocrine neoplasms; population based ... See more keywords
Comprehensive Genomic Profiling of Gastroenteropancreatic Neuroendocrine Neoplasms (GEP-NENs)
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DOI: 10.1158/1078-0432.ccr-20-1804
Abstract: Purpose: GEP-NENs are rare malignancies with increasing incidence. Their molecular characteristics are still undefined. We explored the underlying biology of GEP-NENs and the differences between gastrointestinal (GI) and pancreatic (PNEN), high-grade (HG), and low-grade (LG)… read more here.
Keywords: genomic profiling; gep nens; biology; profiling gastroenteropancreatic ... See more keywords
Gastroenteropancreatic neuroendocrine neoplasms: current development, challenges, and clinical perspectives
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DOI: 10.1186/s40779-024-00535-6
Abstract: Neuroendocrine neoplasms (NENs) are highly heterogeneous and potentially malignant tumors arising from secretory cells of the neuroendocrine system. Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are the most common subtype of NENs. Historically, GEP-NENs have been regarded as… read more here.
Keywords: gep nens; neoplasms current; gastroenteropancreatic neuroendocrine; biology ... See more keywords
Update on Epidemiology, Diagnosis, and Biomarkers in Gastroenteropancreatic Neuroendocrine Neoplasms
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DOI: 10.3390/cancers14051119
Abstract: Simple Summary Neuroendocrine neoplasms are divided into two groups: well-differentiated neuroendocrine tumors and poorly differentiated neuroendocrine carcinomas. The progress in diagnostic methods, including pathology optimization and imaging, might be one of the reasons for the… read more here.
Keywords: epidemiology; gastroenteropancreatic neuroendocrine; neuroendocrine neoplasms; epidemiology diagnosis ... See more keywords
Advances in the Diagnosis and Therapeutic Management of Gastroenteropancreatic Neuroendocrine Neoplasms (GEP-NENs)
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DOI: 10.3390/cancers14082028
Abstract: Simple Summary Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are a group of tumors with different clinical manifestations, various localizations in the human body, and a particularly wide range of histological types, grades and severities. Their diagnosis and… read more here.
Keywords: gep nens; management; gastroenteropancreatic neuroendocrine; treatment ... See more keywords
The Evolving Landscape of GEP-NENs in the Era of Precision Oncology: Molecular Insights into Tumor Heterogeneity
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DOI: 10.3390/cancers17132080
Abstract: Simple Summary Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) arise from neuroendocrine cells in the digestive system and show a wide range of growth patterns. While traditional methods continue to guide diagnosis and grading, they often fall short… read more here.
Keywords: oncology; tumor heterogeneity; gep nens; precision oncology ... See more keywords