Reciprocal stabilisation of glycine receptors and gephyrin scaffold proteins at inhibitory synapses.
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical journal"
DOI: 10.1016/j.bpj.2021.01.024
Abstract: Postsynaptic scaffold proteins immobilise neurotransmitter receptors in the synaptic membrane opposite to presynaptic vesicle release sites, thus ensuring efficient synaptic transmission. At inhibitory synapses in the spinal cord, the main scaffold protein gephyrin assembles in… read more here.
Keywords: inhibitory synapses; scaffold proteins; glycine receptors; gephyrin ... See more keywords
Gephyrin-mediated formation of inhibitory postsynaptic density sheet via phase separation.
Sign Up to like & getrecommendations! Published in 2020 at "Cell research"
DOI: 10.1038/s41422-020-00433-1
Abstract: Inhibitory synapses are also known as symmetric synapses due to their lack of prominent postsynaptic densities (PSDs) under a conventional electron microscope (EM). Recent cryo-EM tomography studies indicated that inhibitory synapses also contain PSDs, albeit… read more here.
Keywords: phase separation; formation; sheet; inhibitory ... See more keywords
A DARPin-based molecular toolset to probe gephyrin and inhibitory synapse biology
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.06.30.498253
Abstract: Neuroscience currently requires the use of antibodies to study synaptic proteins, where antibody binding is used as a correlate to define the presence, plasticity, and regulation of synapses. Gephyrin is an inhibitory synaptic scaffolding protein… read more here.
Keywords: toolset; gephyrin inhibitory; gephyrin; based molecular ... See more keywords
Automated Image Analysis Reveals Different Localization of Synaptic Gephyrin C4 Splice Variants
Sign Up to like & getrecommendations! Published in 2022 at "eNeuro"
DOI: 10.1523/eneuro.0102-22.2022
Abstract: Abstract Postsynaptic scaffolding proteins function as central organization hubs, ensuring the synaptic localization of neurotransmitter receptors, trans-synaptic adhesion proteins, and signaling molecules. Gephyrin is the major postsynaptic scaffolding protein at glycinergic and a subset of… read more here.
Keywords: localization; gephyrin; expression; analysis ... See more keywords
Structure of Heteropentameric GABAA Receptors and Receptor-Anchoring Properties of Gephyrin
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2019.00191
Abstract: γ-Aminobutyric acid type A receptors (GABAARs) mediate the majority of fast synaptic inhibition in the central nervous system (CNS). GABAARs belong to the Cys-loop superfamily of pentameric ligand-gated ion channels (pLGIC) and are assembled from… read more here.
Keywords: synaptic gabaars; heteropentameric gabaa; structure; gabaa receptors ... See more keywords