Geraniol ameliorates diabetic nephropathy via interference with miRNA-21/PTEN/Akt/mTORC1 pathway in rats
Sign Up to like & getrecommendations! Published in 2020 at "Naunyn-Schmiedeberg's Archives of Pharmacology"
DOI: 10.1007/s00210-020-01944-9
Abstract: Deregulated activity of protein kinase B/mammalian target of rapamycin complex-1 (Akt/mTORC1) incites crucial pathological characteristics of diabetic nephropathy. The acyclic monoterpene geraniol has been recently reported to possess antidiabetic effects; however, its potential renoprotective effect… read more here.
Keywords: mtorc1 pathway; pten akt; diabetic nephropathy; akt mtorc1 ... See more keywords
Mechanistic Insights into Ameliorating Effect of Geraniol on D-Galactose Induced Memory Impairment in Rats.
Sign Up to like & getrecommendations! Published in 2022 at "Neurochemical research"
DOI: 10.1007/s11064-022-03559-3
Abstract: Geraniol (GE), an important ingredient in several essential oils, displayed pleiotropic biological activities through targeting multiple signaling cascades. In the current study, we aimed to examine the protective effect of GE on D-galactose (D-gal) induced… read more here.
Keywords: memory impairment; geraniol; impairment; protein ... See more keywords
The potential of geraniol to reduce cytotoxic and genotoxic effects of MNNG in plant and human lymphocyte test-systems
Sign Up to like & getrecommendations! Published in 2019 at "South African Journal of Botany"
DOI: 10.1016/j.sajb.2019.03.005
Abstract: Abstract Geraniol is a common component of essential oils of various plant species and is widely used in cosmetics, perfumery and household products. In the present study, we investigated the cytotoxic, genotoxic and antioxidant activities… read more here.
Keywords: test systems; cytotoxic genotoxic; genotoxic effects; genotoxic ... See more keywords
Tuning Geraniol Biosynthesis via a Novel Decane-Responsive Promoter in Candida glycerinogenes.
Sign Up to like & getrecommendations! Published in 2022 at "ACS synthetic biology"
DOI: 10.1021/acssynbio.2c00003
Abstract: Geraniol is a rose-scented monoterpene with significant commercial and industrial value in medicine, condiments, cosmetics, and bioenergy. Here, we first targeted geraniol as a reporter metabolite and explored the suitability and potential of Candida glycerinogenes… read more here.
Keywords: promoter; decane responsive; geraniol; candida glycerinogenes ... See more keywords
A cytosolic bifunctional geranyl/farnesyl diphosphate synthase provides MVA-derived GPP for geraniol biosynthesis in rose flowers.
Sign Up to like & getrecommendations! Published in 2023 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2221440120
Abstract: Geraniol derived from essential oils of various plant species is widely used in the cosmetic and perfume industries. It is also an essential trait of the pleasant smell of rose flowers. In contrast to other… read more here.
Keywords: biosynthesis; geraniol; farnesyl diphosphate; rose flowers ... See more keywords
Amelioration of Age-Related Multiple Neuronal Impairments and Inflammation in High-Fat Diet-Fed Rats: The Prospective Multitargets of Geraniol
Sign Up to like & getrecommendations! Published in 2022 at "Oxidative Medicine and Cellular Longevity"
DOI: 10.1155/2022/4812993
Abstract: Neuroinflammation is documented to alter brain function as a consequence of metabolic changes linked with a high-fat diet (HFD). The primary target of this study is to see how geraniol is effective in manipulating age-… read more here.
Keywords: inflammation; geraniol; age; fed rats ... See more keywords
Esterification of geraniol as a strategy for increasing product titre and specificity in engineered Escherichia coli
Sign Up to like & getrecommendations! Published in 2019 at "Microbial Cell Factories"
DOI: 10.1186/s12934-019-1130-0
Abstract: BackgroundGeraniol, an acyclic monoterpene alcohol, is found as a primary constituent in the essential oils of plants such as geranium, lemongrass and rose. The floral-like scent of geraniol has made it a popular constituent of… read more here.
Keywords: esterification geraniol; escherichia coli; product; strategy ... See more keywords
Geraniol Ameliorates Sepsis in Neonatal Rats by Regulating Calprotectin and Inflammatory Response
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Food and Nutrition Research"
DOI: 10.12691/jfnr-9-11-1
Abstract: Sepsis is characterized by systemic infection that causes multiple organ dysfunction and is associated with a high mortality rate in the paediatric intensive care unit. In the present study, we investigated the effect of geraniol… read more here.
Keywords: sepsis neonatal; sepsis; neonatal rats; sepsis rats ... See more keywords
Geraniol inhibits biofilm formation of methicillin-resistant Staphylococcus aureus and increase the therapeutic effect of vancomycin in vivo
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.960728
Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) is among the common drug resistant bacteria, which has gained worldwide attention due to its high drug resistance and infection rates. Biofilms produced by S. aureus are known to increase antibiotic… read more here.
Keywords: methicillin resistant; biofilm formation; geraniol; effect ... See more keywords
Renal Ischemia/Reperfusion Mitigation via Geraniol: The Role of Nrf-2/HO-1/NQO-1 and TLR2,4/MYD88/NFκB Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Antioxidants"
DOI: 10.3390/antiox11081568
Abstract: Background: Renal ischemia/reperfusion injury is a clinically recurrent event during kidney transplantation. Geraniol is a natural monoterpene essential oil component. This study aimed to inspect geraniol’s reno-protective actions against renal I/R injury with further analysis… read more here.
Keywords: tlr2 myd88; geraniol; reperfusion; nrf nqo ... See more keywords
Protective Effect of Geraniol on Oxidative, Inflammatory and Apoptotic Alterations in Isoproterenol-Induced Cardiotoxicity: Role of the Keap1/Nrf2/HO-1 and PI3K/Akt/mTOR Pathways
Sign Up to like & getrecommendations! Published in 2020 at "Antioxidants"
DOI: 10.3390/antiox9100977
Abstract: Background: Myocardial infarction (MI) is still a major contributor to mortality worldwide, and therefore, searching for new drugs is an urgent priority. Natural products are a renewable source for medicinally and pharmacologically active molecules. The… read more here.
Keywords: akt; keap1 nrf2; pi3k akt; akt mtor ... See more keywords