De novo biosynthesis of antimycobacterial agent geranylgeranyl acetate from glucose
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical Engineering Journal"
DOI: 10.1016/j.bej.2018.11.008
Abstract: Abstract Geranylgeranyl acetate have been identified as potent and selective inhibitors against Mycobacterium tuberculosis. In this study, the MVA pathway was engineered in Escherichia coli to biosynthesis of the antimycobacterial agent geranylgeranyl acetate from glucose… read more here.
Keywords: agent geranylgeranyl; geranylgeranyl; acetate glucose; biosynthesis antimycobacterial ... See more keywords
Structural Insights into the CotB2-Catalyzed Cyclization of Geranylgeranyl Diphosphate to the Diterpene Cyclooctat-9-en-7-ol.
Sign Up to like & getrecommendations! Published in 2017 at "ACS chemical biology"
DOI: 10.1021/acschembio.7b00154
Abstract: The diterpene cyclase CotB2 catalyzes the cyclization of geranylgeranyl diphosphate (GGPP) to the tricyclic cyclooctat-9-en-7-ol, which is characterized by a 5-8-5-fused ring skeleton. We have previously proposed a cyclization cascade involving a unique carbon-carbon bond… read more here.
Keywords: geranylgeranyl diphosphate; cyclization geranylgeranyl; geranylgeranyl; cyclization ... See more keywords