Structural Insights into the CotB2-Catalyzed Cyclization of Geranylgeranyl Diphosphate to the Diterpene Cyclooctat-9-en-7-ol.
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DOI: 10.1021/acschembio.7b00154
Abstract: The diterpene cyclase CotB2 catalyzes the cyclization of geranylgeranyl diphosphate (GGPP) to the tricyclic cyclooctat-9-en-7-ol, which is characterized by a 5-8-5-fused ring skeleton. We have previously proposed a cyclization cascade involving a unique carbon-carbon bond… read more here.
Keywords: geranylgeranyl diphosphate; cyclization geranylgeranyl; geranylgeranyl; cyclization ... See more keywords
In Vivo Evaluation of Novel Geranylgeranyl Diphosphate Synthase Inhibitors
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DOI: 10.1182/blood-2018-99-113007
Abstract: The enzyme geranylgeranyl diphosphate synthase (GGDPS) synthesizes the 20-carbon isoprenoid geranylgeranyl diphosphate which is used in protein geranylgeranylation reactions. Our work has demonstrated that GGDPS inhibitors (GGDPSIs) represent a novel therapeutic strategy for multiple myeloma… read more here.
Keywords: ram2061; geranylgeranyl diphosphate; ram2061 ram2093; geranylgeranylation ... See more keywords
Geranylgeranyl diphosphate synthase deficiency aggravates lung fibrosis in mice by modulating TGF-β1/BMP-4 signaling
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DOI: 10.1515/hsz-2019-0168
Abstract: Abstract Geranylgeranyl diphosphate synthase (GGPPS) is an enzyme that catalyzes the synthesis of geranylgeranyl pyrophosphate (GGPP). GGPPS is implicated in many disorders, but its role in idiopathic pulmonary fibrosis (IPF) remains unclear. This study aimed… read more here.
Keywords: geranylgeranyl diphosphate; fibrosis; ggpps; mice ... See more keywords