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   Articles with "geranylgeranyl pyrophosphate" as a keyword



Geranylgeranyl pyrophosphate depletion by statins compromises skeletal muscle insulin sensitivity

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recommendations! Published in 2022 at "Journal of Cachexia, Sarcopenia and Muscle"

DOI: 10.1002/jcsm.13061

Abstract: Statins are widely prescribed cholesterol‐lowering drugs but have been shown to increase the risk of type 2 diabetes mellitus. However, the molecular mechanisms underlying the diabetogenic effect of statins are still not fully understood. read more here.

Keywords: pyrophosphate depletion; statins compromises; geranylgeranyl pyrophosphate; depletion statins ... See more keywords

Molecular cloning and functional characterization of multiple geranylgeranyl pyrophosphate synthases (ApGGPPS) from Andrographis paniculata

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recommendations! Published in 2018 at "Plant Cell Reports"

DOI: 10.1007/s00299-018-2353-y

Abstract: Key messageWe found that ApGGPPS1, ApGGPPS2, and ApGGPPS3 can convert IPP and DMAPP to GGPP. ApGGPPS2 is probably involved in andrographolide biosynthesis. ApGGPPS3 may be responsible for the synthesis of the cytosolic GGPP.AbstractAndrographis paniculata is… read more here.

Keywords: ggpp; apggpps2; geranylgeranyl pyrophosphate; apggpps3 ... See more keywords

Synthesis and Evaluation of Structurally Diverse C-2-Substituted Thienopyrimidine-Based Inhibitors of the Human Geranylgeranyl Pyrophosphate Synthase.

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recommendations! Published in 2022 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.1c01913

Abstract: Novel analogues of C-2-substituted thienopyrimidine-based bisphosphonates (C2-ThP-BPs) are described that are potent inhibitors of the human geranylgeranyl pyrophosphate synthase (hGGPPS). Members of this class of compounds induce target-selective apoptosis of multiple myeloma (MM) cells and… read more here.

Keywords: inhibitors human; geranylgeranyl pyrophosphate; thienopyrimidine based; pyrophosphate synthase ... See more keywords

Unraveling the Prenylation-Cancer Paradox in Multiple Myeloma with Novel Geranylgeranyl Pyrophosphate Synthase (GGPPS) Inhibitors.

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recommendations! Published in 2018 at "Journal of medicinal chemistry"

DOI: 10.1021/acs.jmedchem.8b00886

Abstract: Post-translational prenylation of the small GTP-binding proteins (GTPases) is vital to a plethora of biological processes, including cellular proliferation. We have identified a new class of thienopyrimidine-based bisphosphonate (ThP-BP) inhibitors of the human geranylgeranyl pyrophosphate… read more here.

Keywords: multiple myeloma; geranylgeranyl pyrophosphate; prenylation; pyrophosphate synthase ... See more keywords

Engineering dimer mutants of human geranylgeranyl pyrophosphate synthase

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recommendations! Published in 2025 at "PLOS ONE"

DOI: 10.1371/journal.pone.0317437

Abstract: Geranylgeranyl pyrophosphate synthase (GGPPS), a key enzyme in protein prenylation, plays a critical role in cellular signal transduction and is a promising target for cancer therapy. However, the enzyme’s native hexameric quaternary structure presents challenges… read more here.

Keywords: pyrophosphate; geranylgeranyl pyrophosphate; ggpps; wild type ... See more keywords

Crystal Structure of Geranylgeranyl Pyrophosphate Synthase (CrtE) Involved in Cyanobacterial Terpenoid Biosynthesis

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recommendations! Published in 2020 at "Frontiers in Plant Science"

DOI: 10.3389/fpls.2020.00589

Abstract: Cyanobacteria are photosynthetic prokaryotes that perform oxygenic photosynthesis. Due to their ability to use the photon energy of sunlight to fix carbon dioxide into biomass, cyanobacteria are promising hosts for the sustainable production of terpenoids,… read more here.

Keywords: crte; crystal structure; pyrophosphate; geranylgeranyl pyrophosphate ... See more keywords

Statin-Induced Geranylgeranyl Pyrophosphate Depletion Promotes Ferroptosis-Related Senescence in Adipose Tissue

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recommendations! Published in 2022 at "Nutrients"

DOI: 10.3390/nu14204365

Abstract: Statin treatment is accepted to prevent adverse cardiovascular events. However, atorvastatin, an HMG-CoA reductase inhibitor, has been reported to exhibit distinct effects on senescent phenotypes. Whether atorvastatin can induce adipose tissue senescence and the mechanisms… read more here.

Keywords: adipose tissue; senescence; geranylgeranyl pyrophosphate; statin induced ... See more keywords

Genome-Wide Identification of the Geranylgeranyl Pyrophosphate Synthase (GGPS) Gene Family Associated with Natural Rubber Synthesis in Taraxacum kok-saghyz L. Rodin

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recommendations! Published in 2024 at "Plants"

DOI: 10.3390/plants13192788

Abstract: Taraxacum kok-saghyz Rodin (TKS) is a recognized alternative source of natural rubber comparable to the rubber tree. The geranylgeranyl pyrophosphate synthase (GGPS) catalyzed the synthesis of geranylgeranyl pyrophosphate (GGPP), which is an important enzyme in… read more here.

Keywords: gene; geranylgeranyl pyrophosphate; rubber; natural rubber ... See more keywords