Antitumor and antiangiogenic activity of the novel chimeric inhibitor animacroxam in testicular germ cell cancer
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12582
Abstract: Chimeric inhibitors, which merge two drug pharmacophores in a single molecule have become a prominent approach for the design of novel anticancer compounds. Here, we examined animacroxam, which combines histone deacetylase (HDAC) inhibitory and cytoskeleton‐interfering… read more here.
Keywords: inhibitor; testicular germ; germ cell; cell ... See more keywords
Promoter methylation of DNA homologous recombination genes is predictive of the responsiveness to PARP inhibitor treatment in testicular germ cell tumors
Sign Up to like & getrecommendations! Published in 2021 at "Molecular Oncology"
DOI: 10.1002/1878-0261.12909
Abstract: Testicular germ cell tumors (TGCTs) are the most common cancers in men aged 15–39 years and are divided into two major groups, seminomas and nonseminomas. Novel treatment options are required for these patients, to limit… read more here.
Keywords: methylation; testicular germ; promoter methylation; germ cell ... See more keywords
Profiling the 3D interaction between germ cell tumors and microenvironmental cells at the transcriptome and secretome level
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13282
Abstract: The tumor microenvironment (TM), consisting of the extracellular matrix (ECM), fibroblasts, endothelial cells, and immune cells, might affect tumor invasiveness and the outcome of standard chemotherapy. This study investigated the cross talk between germ cell… read more here.
Keywords: germ cell; secretome level; cell; cell tumors ... See more keywords
Somatic cancers: Hijacking germ cell immortality tools
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200212
Abstract: Germ cells are – arguably – the most fascinating and important cells in our bodies, as they pass their genomes from one generation to another thus establishing an immortal germline. To ensure this mission, germ… read more here.
Keywords: germ cell; cell; germ; germline ... See more keywords
Extragonadal germ cell tumors: Not just a matter of location. A review about clinical, molecular and pathological features
Sign Up to like & getrecommendations! Published in 2019 at "Cancer Medicine"
DOI: 10.1002/cam4.2195
Abstract: Extragonadal germ cell tumors (EGGCTs) are uncommon neoplasms, which arise in anatomical locations other than gonads. The pathogenesis of these neoplasms is still poorly understood and it is a matter of debate if they really… read more here.
Keywords: cell tumors; extragonadal germ; germ cell; diagnosis ... See more keywords
A case series and literature review on 98 pediatric patients of germ cell tumor developing growing teratoma syndrome.
Sign Up to like & getrecommendations! Published in 2023 at "Cancer medicine"
DOI: 10.1002/cam4.6017
Abstract: INTRODUCTION Malignant germ cell tumors (MGCTs) can develop either extracranially or intracranially. Growing teratoma syndrome (GTS) may develop in these patients following chemotherapy. Reports on the clinical characteristics and outcomes of GTS in children with… read more here.
Keywords: germ cell; literature review; risk; pediatric patients ... See more keywords
SET domain‐containing protein 5 is required for expression of primordial germ cell specification‐associated genes in murine embryonic stem cells
Sign Up to like & getrecommendations! Published in 2017 at "Cell Biochemistry and Function"
DOI: 10.1002/cbf.3269
Abstract: Primordial germ cell (PGC) specification is one of the most fundamental processes in developmental biology. Because PGCs are a common source of both gametes, generation of PGCs from embryonic stem cells (ESCs) is a useful… read more here.
Keywords: protein; primordial germ; associated genes; germ cell ... See more keywords
α‐Fetoprotein as a predictor of outcome for children with germ cell tumors: A report from the Malignant Germ Cell International Consortium
Sign Up to like & getrecommendations! Published in 2019 at "Cancer"
DOI: 10.1002/cncr.32363
Abstract: There are several studies describing the correlation between unsatisfactory tumor marker decline and a poor prognosis for adult patients treated for germ cell tumors. In pediatric patients, the data are limited. Therefore, this study retrospectively… read more here.
Keywords: fetoprotein predictor; cell; predictor outcome; germ cell ... See more keywords
Cytologic features of gynecologic germ cell tumors and carcinomas exhibiting germ cell tumor differentiation
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Cytopathology"
DOI: 10.1002/cncy.22673
Abstract: In this study, the authors sought to describe the cytologic features of primary gynecologic germ cell tumors and carcinomas exhibiting germ cell differentiation because little information currently exists. read more here.
Keywords: germ cell; germ; cytologic features; gynecologic germ ... See more keywords
Upper gastrointestinal bleed as the initial presentation of seminoma involving the duodenum in an elderly patient with 9 year follow up: A case report and literature review
Sign Up to like & getrecommendations! Published in 2023 at "Diagnostic Cytopathology"
DOI: 10.1002/dc.25119
Abstract: Germ cell tumors are the most common malignancies in males between 20 and 40 years. However, primary extragonadal germ cell tumors are rare and account for 2%–5% of all germ cell neoplasms in adults. Extragonadal germ… read more here.
Keywords: germ cell; germ; upper gastrointestinal; gastrointestinal bleed ... See more keywords
Generation of B6‐Ddx4em1(CreERT2)Utr, a novel CreERT2 knock‐in line, for germ cell lineage by CRISPR/Cas9
Sign Up to like & getrecommendations! Published in 2020 at "genesis"
DOI: 10.1002/dvg.23367
Abstract: Germ cell development is essential for maintaining reproduction in animals. In postpubertal females, oogenesis is a highly complicated event for producing fertilizable oocytes. It starts when dormant primordial oocytes undergo activation to become growing oocytes.… read more here.
Keywords: creert2 utr; germ cell; creert2; knock ... See more keywords