Single‐cell transcriptome analysis of male chicken germ cells reveals changes in signaling pathway‐related gene expression profiles during mitotic arrest
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13600
Abstract: Mitotic arrest is necessary for the embryonic development of germ cells, and thus, it is important to understand the signaling pathways that regulate mitotic arrest. Here, we investigated the signaling pathway dynamics of male embryonic… read more here.
Keywords: cell; arrest; mitotic arrest; germ cells ... See more keywords
Deciphering the Molecular Characteristics of Human Idiopathic Nonobstructive Azoospermia from the Perspective of Germ Cells.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202206852
Abstract: Nonobstructive azoospermia (NOA) is one of the most important causes of male infertility, accounting for 10-15% of infertile men worldwide. Among these, more than 70% of cases are idiopathic NOA (iNOA), whose pathogenesis and molecular… read more here.
Keywords: perspective germ; cell; nonobstructive azoospermia; germ cells ... See more keywords
Design, Synthesis, and Screening of Triazolopyrimidine–Pyrazole Hybrids as Potent Apoptotic Inducers
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DOI: 10.1002/ardp.201700137
Abstract: An efficient synthesis of novel 3‐(3‐aryl‐1‐phenyl‐1H‐pyrazol‐4‐yl)‐5,7‐dimethyl‐[1,2,4]triazolo[4,3‐a]‐pyrimidines was accomplished by the oxidation of pyrimidinylhydrazones by using organoiodine(III) reagent. All new triazolopyrimidine derivatives bearing the pyrazole scaffold were screened to evaluate them as a reproductive toxicant in… read more here.
Keywords: design synthesis; screening triazolopyrimidine; testicular germ; germ cells ... See more keywords
Somatic cancers: Hijacking germ cell immortality tools
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DOI: 10.1002/bies.202200212
Abstract: Germ cells are – arguably – the most fascinating and important cells in our bodies, as they pass their genomes from one generation to another thus establishing an immortal germline. To ensure this mission, germ… read more here.
Keywords: germ cell; cell; germ; germline ... See more keywords
In vitro responses to known in vivo genotoxic agents in mouse germ cells
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DOI: 10.1002/em.22075
Abstract: Genotoxic compounds have induced DNA damage in male germ cells and have been associated with adverse clinical outcomes including enhanced risks for maternal, paternal and offspring health. DNA strand breaks represent a great threat to… read more here.
Keywords: germ cells; dna damage; genotoxic; mms ... See more keywords
Ovary micromorphology and oogenesis in a rhyacodriline oligochaete (Clitellata: Naididae, Rhyacodrilinae)
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DOI: 10.1002/jmor.21461
Abstract: The main goal of the article is to describe the ovary organization and oogenesis in Peristodrilus montanus, an aquatic oligochaete of the subfamily Rhyacodrilinae. The presented analysis will not only enrich the knowledge about how… read more here.
Keywords: ovary organization; oogenesis; micromorphology oogenesis; germ cells ... See more keywords
Biology of primordial germ cells in vertebrates with emphasis in urodeles amphibians.
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DOI: 10.1002/mrd.23533
Abstract: Primordial germ cells (PGCs) are highly specialized cells that play a relevant role in the maintenance and evolution of the species, since they create new combinations of genetic information between the organisms. Amphibians are a… read more here.
Keywords: primordial germ; urodeles amphibians; biology primordial; germ cells ... See more keywords
Transcriptional dynamics of the circulating chicken primordial germ cells revealing key genes in cell adhesion and proliferation prior to gonad colonization
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DOI: 10.1002/mrd.23558
Abstract: Primordial germ cells (PGCs), precursors to sperms and oocytes, are responsible for the transfer of genetic information to the next generation. The PGCs arise far away from the developing gonad and thus have to migrate… read more here.
Keywords: colonization; cell adhesion; pgcs; germ cells ... See more keywords
Generation of germ cells from pluripotent stem cells in mammals
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DOI: 10.1002/rmb2.12077
Abstract: The germ cell lineage transmits genetic and epigenetic information to the next generation. Primordial germ cells (PGCs), the early embryonic precursors of sperm or eggs, have been studied extensively. Recently, in vitro models of PGC… read more here.
Keywords: cells pluripotent; generation germ; germ cells; generation ... See more keywords
Mouse Fetal Germ Cell Isolation and Culture Techniques.
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DOI: 10.1007/978-1-4939-4017-2_13
Abstract: The fetal gonad contains a great variety of differentiating cell populations, of which germ cells make up a small percentage. In order to study germ cell-specific gene and protein expression, as well as determine direct… read more here.
Keywords: cell; germ cells; germ; germ cell ... See more keywords
The Physiological Role and Regulation of Aquaporins in Teleost Germ Cells.
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DOI: 10.1007/978-94-024-1057-0_10
Abstract: The unicellular germ cells and gametes of oviparous teleosts lack the osmoregulatory organs present in juveniles and adults, yet during development and particularly at spawning, they face tremendous osmotic challenges when released into the external… read more here.
Keywords: regulation aquaporins; physiological role; germ cells; role regulation ... See more keywords