Single‐cell transcriptome analysis of male chicken germ cells reveals changes in signaling pathway‐related gene expression profiles during mitotic arrest
Sign Up to like & getrecommendations! Published in 2023 at "FEBS Open Bio"
DOI: 10.1002/2211-5463.13600
Abstract: Mitotic arrest is necessary for the embryonic development of germ cells, and thus, it is important to understand the signaling pathways that regulate mitotic arrest. Here, we investigated the signaling pathway dynamics of male embryonic… read more here.
Keywords: cell; arrest; mitotic arrest; germ cells ... See more keywords
Deciphering the Molecular Characteristics of Human Idiopathic Nonobstructive Azoospermia from the Perspective of Germ Cells.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202206852
Abstract: Nonobstructive azoospermia (NOA) is one of the most important causes of male infertility, accounting for 10-15% of infertile men worldwide. Among these, more than 70% of cases are idiopathic NOA (iNOA), whose pathogenesis and molecular… read more here.
Keywords: perspective germ; cell; nonobstructive azoospermia; germ cells ... See more keywords
Design, Synthesis, and Screening of Triazolopyrimidine–Pyrazole Hybrids as Potent Apoptotic Inducers
Sign Up to like & getrecommendations! Published in 2017 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.201700137
Abstract: An efficient synthesis of novel 3‐(3‐aryl‐1‐phenyl‐1H‐pyrazol‐4‐yl)‐5,7‐dimethyl‐[1,2,4]triazolo[4,3‐a]‐pyrimidines was accomplished by the oxidation of pyrimidinylhydrazones by using organoiodine(III) reagent. All new triazolopyrimidine derivatives bearing the pyrazole scaffold were screened to evaluate them as a reproductive toxicant in… read more here.
Keywords: design synthesis; screening triazolopyrimidine; testicular germ; germ cells ... See more keywords
Somatic cancers: Hijacking germ cell immortality tools
Sign Up to like & getrecommendations! Published in 2022 at "BioEssays"
DOI: 10.1002/bies.202200212
Abstract: Germ cells are – arguably – the most fascinating and important cells in our bodies, as they pass their genomes from one generation to another thus establishing an immortal germline. To ensure this mission, germ… read more here.
Keywords: germ cell; cell; germ; germline ... See more keywords
In vitro responses to known in vivo genotoxic agents in mouse germ cells
Sign Up to like & getrecommendations! Published in 2017 at "Environmental and Molecular Mutagenesis"
DOI: 10.1002/em.22075
Abstract: Genotoxic compounds have induced DNA damage in male germ cells and have been associated with adverse clinical outcomes including enhanced risks for maternal, paternal and offspring health. DNA strand breaks represent a great threat to… read more here.
Keywords: germ cells; dna damage; genotoxic; mms ... See more keywords
Ovary micromorphology and oogenesis in a rhyacodriline oligochaete (Clitellata: Naididae, Rhyacodrilinae)
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Morphology"
DOI: 10.1002/jmor.21461
Abstract: The main goal of the article is to describe the ovary organization and oogenesis in Peristodrilus montanus, an aquatic oligochaete of the subfamily Rhyacodrilinae. The presented analysis will not only enrich the knowledge about how… read more here.
Keywords: ovary organization; oogenesis; micromorphology oogenesis; germ cells ... See more keywords
Biology of primordial germ cells in vertebrates with emphasis in urodeles amphibians.
Sign Up to like & getrecommendations! Published in 2021 at "Molecular reproduction and development"
DOI: 10.1002/mrd.23533
Abstract: Primordial germ cells (PGCs) are highly specialized cells that play a relevant role in the maintenance and evolution of the species, since they create new combinations of genetic information between the organisms. Amphibians are a… read more here.
Keywords: primordial germ; urodeles amphibians; biology primordial; germ cells ... See more keywords
Transcriptional dynamics of the circulating chicken primordial germ cells revealing key genes in cell adhesion and proliferation prior to gonad colonization
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.23558
Abstract: Primordial germ cells (PGCs), precursors to sperms and oocytes, are responsible for the transfer of genetic information to the next generation. The PGCs arise far away from the developing gonad and thus have to migrate… read more here.
Keywords: colonization; cell adhesion; pgcs; germ cells ... See more keywords
The RNA‐Binding Protein IGF2BP1 Marks Germ Cells but Is Dispensable for Mouse Fertility
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.70016
Abstract: Insulin‐like growth factor 2 mRNA binding protein 1 (IGF2BP1) is a key reader of N6‐methyladenosine modifications that regulate target mRNA stability in eukaryotic cells; however, its role in germ cells has never been explored. Here,… read more here.
Keywords: protein igf2bp1; germ cells; igf2bp1; binding protein ... See more keywords
Programming for Meiotic Competence in Mouse Male Germ Cells is Established at the Perinatal Precursor Stage of Development
Sign Up to like & getrecommendations! Published in 2025 at "Molecular Reproduction and Development"
DOI: 10.1002/mrd.70032
Abstract: Meiosis is a fundamental aspect of gametogenesis, but how and when the programming is established in germ cells during development is unknown. In the mammalian male germline, mitotic differentiating spermatogonia with the competence for meiotic… read more here.
Keywords: programming meiotic; stage; meiotic competence; competence ... See more keywords
Generation of germ cells from pluripotent stem cells in mammals
Sign Up to like & getrecommendations! Published in 2018 at "Reproductive Medicine and Biology"
DOI: 10.1002/rmb2.12077
Abstract: The germ cell lineage transmits genetic and epigenetic information to the next generation. Primordial germ cells (PGCs), the early embryonic precursors of sperm or eggs, have been studied extensively. Recently, in vitro models of PGC… read more here.
Keywords: cells pluripotent; generation germ; germ cells; generation ... See more keywords