No difference in 4‐nitroquinoline induced tumorigenesis between germ‐free and colonized mice
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22972
Abstract: Variations in oral bacterial communities have been linked to oral cancer suggesting that the oral microbiome is an etiological factor that can influence oral cancer development. The 4‐nitroquinoline 1‐oxide (4‐NQO)‐induced murine oral and esophageal cancer… read more here.
Keywords: tumorigenesis; difference nitroquinoline; germ free; mice ... See more keywords
Best practices for germ-free derivation and gnotobiotic zebrafish husbandry.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in cell biology"
DOI: 10.1016/bs.mcb.2016.11.005
Abstract: All animals are ecosystems with resident microbial communities, referred to as microbiota, which play profound roles in host development, physiology, and evolution. Enabled by new DNA sequencing technologies, there is a burgeoning interest in animal-microbiota… read more here.
Keywords: derivation; husbandry; best practices; biology ... See more keywords
Role of germ-free animal models in understanding interactions of gut microbiota to host and environmental health: A special reference to zebrafish.
Sign Up to like & getrecommendations! Published in 2021 at "Environmental pollution"
DOI: 10.1016/j.envpol.2021.116925
Abstract: Numerous pieces of evidence documented the importance of gut microbiota in regulating human health and evaluating the toxicity of environmental pollutants, which are closely related to the host health in various aspects, including nutrition, energy… read more here.
Keywords: free animal; germ free; gut microbiota; host ... See more keywords
Estrous cycle and ovariectomy-induced changes in visceral pain are microbiota-dependent
Sign Up to like & getrecommendations! Published in 2021 at "iScience"
DOI: 10.1016/j.isci.2021.102850
Abstract: Summary Visceral hypersensitivity (VH) is a hallmark of many functional gastrointestinal disorders including irritable bowel syndrome and is categorized by a dull, diffuse sensation of abdominal pain. Recently, the gut microbiota has been implicated in… read more here.
Keywords: ovariectomy; visceral pain; estrous cycle; germ free ... See more keywords
Microbial Signals Link Westernized Diet to Metabolic Inflammation: More Evidence to Resolve Controversies
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Gastroenterology and Hepatology"
DOI: 10.1016/j.jcmgh.2019.11.005
Abstract: ost immune responses and the gut microbiota are Htightly connected and collectively contribute to the regulation of metabolic homeostasis. Disturbance of this interplay is implicated in the development of the metabolic syndrome, a multifactorial condition… read more here.
Keywords: gut; free mice; inflammation; germ free ... See more keywords
Potential of Establishing the Corresponding Human Microbial Community in Pseudo Germ-Free Mice through Fecal Microbe Transfer from Three Urolithin Metabotypes.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.2c02796
Abstract: Three urolithin metabotypes (UMs) have been defined in the population according to final urolithins converted by gut microbiota. Currently, it is difficult to establish the cause-and-effect relationship between urolithins and microbiota in human studies. Studies… read more here.
Keywords: urolithin metabotypes; pseudo germ; hma mice; free mice ... See more keywords
Secretory IgA N-glycans contribute to the protection against E. coli O55 infection of germ-free piglets
Sign Up to like & getrecommendations! Published in 2020 at "Mucosal Immunology"
DOI: 10.1038/s41385-020-00345-8
Abstract: Mucosal surfaces are colonized by highly diverse commensal microbiota. Coating with secretory IgA (SIgA) promotes the survival of commensal bacteria while it inhibits the invasion by pathogens. Bacterial coating could be mediated by antigen-specific SIgA… read more here.
Keywords: protection; coli o55; secretory iga; germ free ... See more keywords
Production of germ-free mosquitoes via transient colonisation allows stage-specific investigation of host–microbiota interactions
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-21195-3
Abstract: The mosquito microbiota impacts the physiology of its host and is essential for normal larval development, thereby influencing transmission of vector-borne pathogens. Germ-free mosquitoes generated with current methods show larval stunting and developmental deficits. Therefore,… read more here.
Keywords: microbiota; study; free mosquitoes; colonisation ... See more keywords
Aspirin Reduces Colorectal Tumor Development in Mice and Gut Microbes Reduce its Bioavailability and Chemopreventive Effects.
Sign Up to like & getrecommendations! Published in 2020 at "Gastroenterology"
DOI: 10.1053/j.gastro.2020.05.004
Abstract: BACKGROUND & AIMS Alterations in the intestinal microbiota affect development of colorectal cancer (CRC) and drug metabolism. We studied whether the intestinal microbiota affects the ability of aspirin to reduce colon tumor development in mice.… read more here.
Keywords: tumor development; germ free; mice; mice given ... See more keywords
Germ-free housing conditions do not affect aortic root and aortic arch lesion size of late atherosclerotic low-density lipoprotein receptor-deficient mice
Sign Up to like & getrecommendations! Published in 2020 at "Gut Microbes"
DOI: 10.1080/19490976.2020.1767463
Abstract: ABSTRACT The microbiota has been linked to the development of atherosclerosis, but the functional impact of these resident bacteria on the lesion size and cellular composition of atherosclerotic plaques in the aorta has never been… read more here.
Keywords: lesion size; aortic arch; root; size ... See more keywords
Gut microbiota modulates visceral sensitivity through calcitonin gene-related peptide (CGRP) production
Sign Up to like & getrecommendations! Published in 2023 at "Gut Microbes"
DOI: 10.1080/19490976.2023.2188874
Abstract: ABSTRACT Abdominal pain is common in patients with gastrointestinal disorders, but its pathophysiology is unclear, in part due to poor understanding of basic mechanisms underlying visceral sensitivity. Accumulating evidence suggests that gut microbiota is an… read more here.
Keywords: gut microbiota; visceral sensitivity; germ free; production ... See more keywords