Addressing the Chemistry of Germacrene A by Isotope Labeling Experiments.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b00725
Abstract: Despite the central role of germacrene A in sesquiterpene biosynthesis and its widespread occurrence in nature, its complete NMR characterization is still pending. This problem was solved through enzymatic preparation of germacrene A isotopomers that… read more here.
Keywords: isotope labeling; addressing chemistry; germacrene; chemistry ... See more keywords
Characterization and functional reconstruction of a highly productive germacrene A synthase from Liriodendron chinense
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DOI: 10.1111/pbi.70023
Abstract: Plants produce a large array of natural products which play important roles in flavours, fragrances and medicines. However, some high‐value plant intermediate metabolites cannot be directly extracted from plants. The tulip tree (Liriodendron chinense) in… read more here.
Keywords: functional reconstruction; liriodendron; liriodendron chinense; characterization functional ... See more keywords
Protein Engineering of a Germacrene A Synthase From Lactuca sativa and Its Application in High Productivity of Germacrene A in Escherichia coli
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.932966
Abstract: Germacrene A (GA) is a key intermediate for the synthesis of medicinal active compounds, especially for β-elemene, which is a broad-spectrum anticancer drug. The production of sufficient GA in the microbial platform is vital for… read more here.
Keywords: germacrene; escherichia coli; lactuca sativa; synthase lactuca ... See more keywords
Cloning and Functional Characterization of Two Germacrene A Oxidases Isolated from Xanthium sibiricum
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27103322
Abstract: Sesquiterpene lactones (STLs) from the cocklebur Xanthium sibiricum exhibit significant anti-tumor activity. Although germacrene A oxidase (GAO), which catalyzes the production of Germacrene A acid (GAA) from germacrene A, an important precursor of germacrene-type STLs,… read more here.
Keywords: functional characterization; germacrene; xanthium sibiricum; gao ... See more keywords