Addressing the Chemistry of Germacrene A by Isotope Labeling Experiments.
Sign Up to like & getrecommendations! Published in 2019 at "Organic letters"
DOI: 10.1021/acs.orglett.9b00725
Abstract: Despite the central role of germacrene A in sesquiterpene biosynthesis and its widespread occurrence in nature, its complete NMR characterization is still pending. This problem was solved through enzymatic preparation of germacrene A isotopomers that… read more here.
Keywords: isotope labeling; addressing chemistry; germacrene; chemistry ... See more keywords
Protein Engineering of a Germacrene A Synthase From Lactuca sativa and Its Application in High Productivity of Germacrene A in Escherichia coli
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2022.932966
Abstract: Germacrene A (GA) is a key intermediate for the synthesis of medicinal active compounds, especially for β-elemene, which is a broad-spectrum anticancer drug. The production of sufficient GA in the microbial platform is vital for… read more here.
Keywords: germacrene; escherichia coli; lactuca sativa; synthase lactuca ... See more keywords
Cloning and Functional Characterization of Two Germacrene A Oxidases Isolated from Xanthium sibiricum
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27103322
Abstract: Sesquiterpene lactones (STLs) from the cocklebur Xanthium sibiricum exhibit significant anti-tumor activity. Although germacrene A oxidase (GAO), which catalyzes the production of Germacrene A acid (GAA) from germacrene A, an important precursor of germacrene-type STLs,… read more here.
Keywords: functional characterization; germacrene; xanthium sibiricum; gao ... See more keywords