Bioinformatics analysis of miRNAs germacrone protection on diabetic nephropathy
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-81944-4
Abstract: Diabetes nephropathy (DN) is a prevalent and severe microvascular diabetic complication. Despite the recent developments in germacrone-based therapies for DN, the underlying mechanisms of germacrone in DN remain poorly understood. This study used comprehensive bioinformatics… read more here.
Keywords: group; mmu mir; bioinformatics analysis; germacrone ... See more keywords
Novel anti-cancer agents based on germacrone: design, synthesis, biological activity, docking studies and MD simulations
Sign Up to like & getrecommendations! Published in 2017 at "RSC Advances"
DOI: 10.1039/c6ra26944c
Abstract: Germacrone is a major activity component found in Curcuma zedoaria oil product, which is extracted from Curcuma zedoaria. In the present study, novel germacrone derivatives were first designed based on the theories of bioalkylating agents,… read more here.
Keywords: docking studies; germacrone; novel anti; met kinase ... See more keywords
Germacrone Inhibits Cell Proliferation and Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cells
Sign Up to like & getrecommendations! Published in 2020 at "BioMed Research International"
DOI: 10.1155/2020/7643248
Abstract: Germacrone, a natural 10-membered monocyclic sesquiterpene with three double bonds and a ketone, was isolated from the roots of traditional Chinese medicine Saussurea costus (SC). The pharmacological value and intrinsic mechanism of germacrone in the… read more here.
Keywords: cell carcinoma; squamous cell; germacrone; escc cells ... See more keywords
The effect and mechanism of Germacrone in ameliorating alcoholic fatty liver by inhibiting Nrf2/Rbp4
Sign Up to like & getrecommendations! Published in 2025 at "Chinese Medicine"
DOI: 10.1186/s13020-025-01132-y
Abstract: Alcohol-related liver disease (ALD) is an important cause of the increase in liver disease-related morbidity and mortality worldwide. Its core pathological features are oxidative stress imbalance and lipid metabolism disorders. Nuclear factor E2-related factor 2… read more here.
Keywords: rbp4; oxidative stress; nrf2 rbp4; ald ... See more keywords
Germacrone Induces Apoptosis as Well as Protective Autophagy in Human Prostate Cancer Cells
Sign Up to like & getrecommendations! Published in 2020 at "Cancer Management and Research"
DOI: 10.2147/cmar.s250522
Abstract: Background Germacrone, a natural product isolated from the traditional Chinese medicine Rhizoma Curcuma, has been reported to exhibit antitumor activities in vitro. To further understand the antitumor mechanism of germacrone, we investigated the growth inhibitory… read more here.
Keywords: autophagy; cancer cells; germacrone; cancer ... See more keywords
The Hepatotoxicity of Alantolactone and Germacrone: Their Influence on Cholesterol and Lipid Metabolism in Differentiated HepaRG Cells
Sign Up to like & getrecommendations! Published in 2020 at "Nutrients"
DOI: 10.3390/nu12061720
Abstract: The sesquiterpenes alantolactone (ATL) and germacrone (GER) are potential anticancer agents of natural origin. Their toxicity and biological activity have been evaluated using the differentiated HepaRG (dHepaRG) cells, a hepatocyte-like model. The half-maximal inhibitory concentrations… read more here.
Keywords: differentiated heparg; germacrone; lipid metabolism; cholesterol lipid ... See more keywords