Novel anti-cancer agents based on germacrone: design, synthesis, biological activity, docking studies and MD simulations
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DOI: 10.1039/c6ra26944c
Abstract: Germacrone is a major activity component found in Curcuma zedoaria oil product, which is extracted from Curcuma zedoaria. In the present study, novel germacrone derivatives were first designed based on the theories of bioalkylating agents,… read more here.
Keywords: docking studies; germacrone; novel anti; met kinase ... See more keywords
Germacrone Inhibits Cell Proliferation and Induces Apoptosis in Human Esophageal Squamous Cell Carcinoma Cells
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DOI: 10.1155/2020/7643248
Abstract: Germacrone, a natural 10-membered monocyclic sesquiterpene with three double bonds and a ketone, was isolated from the roots of traditional Chinese medicine Saussurea costus (SC). The pharmacological value and intrinsic mechanism of germacrone in the… read more here.
Keywords: cell carcinoma; squamous cell; germacrone; escc cells ... See more keywords
Germacrone Induces Apoptosis as Well as Protective Autophagy in Human Prostate Cancer Cells
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DOI: 10.2147/cmar.s250522
Abstract: Background Germacrone, a natural product isolated from the traditional Chinese medicine Rhizoma Curcuma, has been reported to exhibit antitumor activities in vitro. To further understand the antitumor mechanism of germacrone, we investigated the growth inhibitory… read more here.
Keywords: autophagy; cancer cells; germacrone; cancer ... See more keywords
The Hepatotoxicity of Alantolactone and Germacrone: Their Influence on Cholesterol and Lipid Metabolism in Differentiated HepaRG Cells
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DOI: 10.3390/nu12061720
Abstract: The sesquiterpenes alantolactone (ATL) and germacrone (GER) are potential anticancer agents of natural origin. Their toxicity and biological activity have been evaluated using the differentiated HepaRG (dHepaRG) cells, a hepatocyte-like model. The half-maximal inhibitory concentrations… read more here.
Keywords: differentiated heparg; germacrone; lipid metabolism; cholesterol lipid ... See more keywords