T cell‐dependent antigen adjuvanted with DOTAP‐CpG‐B but not DOTAP‐CpG‐A induces robust germinal center responses and high affinity antibodies in mice
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Immunology"
DOI: 10.1002/eji.201747113
Abstract: The development of vaccines for infectious diseases for which we currently have none, including HIV, will likely require the use of adjuvants that strongly promote germinal center responses and somatic hypermutation to produce broadly neutralizing… read more here.
Keywords: germinal center; center responses; cell dependent; dotap cpg ... See more keywords
A novel allele for inducible Cre expression in germinal center B cells
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Immunology"
DOI: 10.1002/eji.201847863
Abstract: The germinal center reaction is essential for efficient humoral immunity, but it can also give rise to B cell lymphomas. Cre/loxP‐mediated conditional gene knock‐out or knock‐in can be used for the genetic manipulation of germinal… read more here.
Keywords: germinal center; novel allele; allele inducible; inducible cre ... See more keywords
Heterogeneity of germinal center B cells: New insights from single-cell studies.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of immunology"
DOI: 10.1002/eji.202149235
Abstract: Upon antigen exposure, activated B cells in antigen-draining lymphoid organs form micro-anatomical structures, called germinal centers (GCs), where affinity maturation occurs. Within the GC microenvironment, GC B cells undergo proliferation and B cell receptor (BCR)… read more here.
Keywords: single cell; germinal center; affinity; center cells ... See more keywords
BOB.1/OBF.1 is required during B‐cell ontogeny for B‐cell differentiation and germinal center function
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Immunology"
DOI: 10.1002/eji.202149333
Abstract: BOB.1/OBF.1 is a lymphocyte‐specific transcriptional co‐activator of octamer‐dependent transcription. It regulates the expression of genes important for lymphocyte physiology together with the Oct‐1 and Oct‐2 transcription factors. So far, BOB.1/OBF.1 has been studied in conventional… read more here.
Keywords: bob obf; cell development; cell; germinal center ... See more keywords
Cultivation of Encapsulated Primary Human B Lymphocytes: A First Step towards a Bioartificial Germinal Center.
Sign Up to like & getrecommendations! Published in 2022 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202200256
Abstract: Polyelectrolyte microcapsules based on sodium cellulose sulfate (SCS) and poly-diallyl-dimethyl-ammonium chloride (PDADMAC) have previously been proposed as a suitable ex vivo microenvironment for the cultivation and differentiation of primary human T lymphocytes. Here, the same… read more here.
Keywords: cell; primary human; cultivation; human lymphocytes ... See more keywords
Determining the Origin of Human Germinal Center B Cell-Derived Malignancies.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7095-7_20
Abstract: Most human B cell lymphomas originate from germinal center (GC) B cells. This is partly caused by the high proliferative activity of GC B cells and the remodeling processes acting at the immunoglobulin (Ig) loci… read more here.
Keywords: germinal center; gene; cell; somatic hypermutation ... See more keywords
Mathematical modeling of lymphocytes selection in the germinal center
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Mathematical Biology"
DOI: 10.1007/s00285-016-1038-9
Abstract: Lymphocyte selection is a fundamental process of adaptive immunity. In order to produce B-lymphocytes with a target antigenic profile, mutation selection and division occur in the germinal center, a specific part of lymph nodes. We… read more here.
Keywords: germinal center; selection germinal; mathematical modeling; lymphocytes selection ... See more keywords
A synthetic stroma-free germinal center niche for efficient generation of humoral immunity ex vivo.
Sign Up to like & getrecommendations! Published in 2018 at "Biomaterials"
DOI: 10.1016/j.biomaterials.2018.02.039
Abstract: B cells play a major role in the adaptive immune response by producing antigen-specific antibodies against pathogens and imparting immunological memory. Following infection or vaccination, antibody-secreting B cells and memory B cells are generated in… read more here.
Keywords: germinal center; like cells; antigen specific; sgc reaction ... See more keywords
Germinal center responses to SARS-CoV-2 mRNA vaccines in healthy and immunocompromised individuals
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DOI: 10.1016/j.cell.2022.01.027
Abstract: Vaccine-mediated immunity often relies on the generation of protective antibodies and memory B cells, which commonly stem from germinal center (GC) reactions. An in-depth comparison of the GC responses elicited by SARS-CoV-2 mRNA vaccines in… read more here.
Keywords: mrna vaccines; sars cov; immunocompromised individuals; germinal center ... See more keywords
Getting to the (germinal) center of humoral immune responses to SARS-CoV-2
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DOI: 10.1016/j.cell.2022.02.018
Abstract: Long-term protection against SARS-CoV-2 requires effective and durable immunity. In this issue of Cell, two papers closely examine germinal centers, the physiological birthplace of adaptive immunity, to quantify the specificity, breadth, magnitude, and persistence of… read more here.
Keywords: sars cov; germinal center; humoral immune; center humoral ... See more keywords
Follicular T cells optimize the germinal center response to SARS-CoV-2 protein vaccination in mice
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DOI: 10.1016/j.celrep.2022.110399
Abstract: Follicular helper T (Tfh) cells promote, whereas follicular regulatory T (Tfr) cells restrain, germinal center (GC) reactions. However, the precise roles of these cells in the complex GC reaction remain poorly understood. Here, we perturb… read more here.
Keywords: sars cov; vaccination; germinal center; tfr cells ... See more keywords