Complete Visualization of T Follicular Helper Cells in Germinal Centers by Light Sheet Fluorescence Microscopy.
Sign Up to like & getrecommendations! Published in 2022 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-1736-6_1
Abstract: Long-lasting immunity depends on generation of antibody forming cells in germinal centers (GCs). Conventional methods such as immunohistology and intravital live imaging have been used extensively to investigate the location of cellular assemblies within tissues… read more here.
Keywords: microscopy; cells germinal; germinal centers; follicular helper ... See more keywords
Progressive transformation of germinal centers: an illustration of two clinical cases
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Hematology"
DOI: 10.1007/s00277-018-3257-1
Abstract: Dear Editor, Progressive transformation of germinal centers (PTGC) is a common, but often underdiagnosed cause of benign peripheral lymphadenopathy that is characterized by reactive follicular hyperplasia along with mantle zone lymphocyte expansion into the adjacent… read more here.
Keywords: transformation germinal; lymphoma; progressive transformation; germinal centers ... See more keywords
Editorial overview: Germinal centers and memory B-cells: from here to eternity.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in immunology"
DOI: 10.1016/j.coi.2017.05.002
Abstract: avid Mathew Tarlinton completed his dergraduate Science degree at the niversity of Sydney in 1971, majoring in enetics. He worked in the Tissue Typing boratory of the Red Cross Blood Bank in ydney before commencing… read more here.
Keywords: centers memory; memory cells; overview germinal; germinal centers ... See more keywords
Class-Switch Recombination Occurs Infrequently in Germinal Centers.
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DOI: 10.1016/j.immuni.2019.07.001
Abstract: Class-switch recombination (CSR) is a DNA recombination process that replaces the immunoglobulin (Ig) constant region for the isotype that can best protect against the pathogen. Dysregulation of CSR can cause self-reactive BCRs and B cell… read more here.
Keywords: class switch; germinal centers; switch recombination; recombination ... See more keywords
Monocytes asphyxiate germinal centers.
Sign Up to like & getrecommendations! Published in 2022 at "Immunity"
DOI: 10.1016/j.immuni.2022.02.007
Abstract: Some bacteria and parasites, such as Salmonella, actively disrupt germinal centers and elicit only low affinity antibodies, but the mechanisms by which microbes alter these responses is poorly understood. In this issue of Immunity, Biram… read more here.
Keywords: asphyxiate germinal; monocytes asphyxiate; germinal centers;
Dopamine in germinal centers
Sign Up to like & getrecommendations! Published in 2017 at "Nature Immunology"
DOI: 10.1038/ni.3825
Abstract: Commensal microbes colonize mucosal surfaces throughout the body, but whether there is a resident population of microbes present on the ocular surface has been controversial. In Immunity, Caspi and colleagues establish that Cornyebacterium mastitidis is… read more here.
Keywords: mastitidis; dopamine germinal; germinal centers; conjunctiva ... See more keywords
Tunable dynamics of B cell selection in gut germinal centers
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DOI: 10.1038/s41586-020-2865-9
Abstract: Germinal centers (GCs), structures normally associated with B cell immunoglobulin (Ig) hypermutation and development of high-affinity antibodies upon infection or immunization, are present in gut-associated lymphoid organs of humans and mice under steady state. Gut-associated… read more here.
Keywords: affinity; selection; germinal centers; steady state ... See more keywords
Do Memory B Cells Form Secondary Germinal Centers? Yes and No.
Sign Up to like & getrecommendations! Published in 2018 at "Cold Spring Harbor perspectives in biology"
DOI: 10.1101/cshperspect.a029405
Abstract: Memory is the defining feature of the adaptive immune system. Humoral immune memory is largely though not exclusively generated in the germinal center (GC), which spawns long-lived plasma cells that support ongoing serum antibody titers… read more here.
Keywords: form secondary; memory cells; secondary germinal; germinal centers ... See more keywords
Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers
Sign Up to like & getrecommendations! Published in 2019 at "Science"
DOI: 10.1126/science.aat9120
Abstract: HIV glycans and nanoparticle vaccines Synthetic nanoparticles have attracted widespread interest for vaccine design, but how the immune system generates a response to multimeric nanoparticles remains unclear. Tokatlian et al. studied immunity generated by HIV… read more here.
Keywords: hiv nanoparticle; nanoparticle; germinal centers; innate immune ... See more keywords
Germinal Centers.
Sign Up to like & getrecommendations! Published in 2022 at "Annual review of immunology"
DOI: 10.1146/annurev-immunol-120419-022408
Abstract: Germinal centers (GCs) are microanatomical sites of B cell clonal expansion and antibody affinity maturation. Therein, B cells undergo the Darwinian process of somatic diversification and affinity-driven selection of immunoglobulins that produces the high-affinity antibodies essential for… read more here.
Keywords: review; affinity; immunology; selection ... See more keywords
DOCK8 is essential for LFA-1 dependent positioning of T follicular helper cells in germinal centers.
Sign Up to like & getrecommendations! Published in 2020 at "JCI insight"
DOI: 10.1172/jci.insight.134508
Abstract: T follicular helper (Tfh) cell migration into germinal centers (GC) is essential for the generation of GC B cells and antibody responses to T dependent (TD) antigens. This process requires interactions between LFA-1 on Tfh… read more here.
Keywords: dependent positioning; germinal centers; follicular helper; antibody responses ... See more keywords